7EZF
| Indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, 7-chloranyl-5-ethyl-3-(3-hydroxy-3-oxopropyl)-1H-indole-2-carboxylic acid, Fructose-1,6-bisphosphatase 1 | Authors: | Wang, X.Y, Zhou, J, Xu, B.L. | Deposit date: | 2021-06-01 | Release date: | 2022-06-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Discovery of Novel Indole Derivatives as Fructose-1,6-bisphosphatase Inhibitors and X-ray Cocrystal Structures Analysis. Acs Med.Chem.Lett., 13, 2022
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5E4E
| Engineered Interleukin-13 bound to receptor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-13, Interleukin-13 receptor subunit alpha-1, ... | Authors: | Moraga, I, Thomas, C, Jude, K.M, Garcia, K.C. | Deposit date: | 2015-10-05 | Release date: | 2015-12-02 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency. Sci.Signal., 8, 2015
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2RK4
| Structure of M26I DJ-1 | Descriptor: | Protein DJ-1 | Authors: | Lakshminarasimhan, M, Maldonado, M.T, Zhou, W, Fink, A.L, Wilson, M.A. | Deposit date: | 2007-10-16 | Release date: | 2008-01-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1. Biochemistry, 47, 2008
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4HC7
| Crystal structure of the full DNA binding domain of GATA3-complex 2 | Descriptor: | DNA (5'-D(*AP*AP*GP*GP*TP*TP*AP*TP*CP*TP*CP*TP*GP*AP*TP*TP*TP*AP*GP*G)-3'), DNA (5'-D(*TP*TP*CP*CP*TP*AP*AP*AP*TP*CP*AP*GP*AP*GP*AP*TP*AP*AP*CP*C)-3'), Trans-acting T-cell-specific transcription factor GATA-3, ... | Authors: | Chen, Y, Bates, D.L, Dey, R, Chen, L. | Deposit date: | 2012-09-28 | Release date: | 2012-12-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | DNA Binding by GATA Transcription Factor Suggests Mechanisms of DNA Looping and Long-Range Gene Regulation. Cell Rep, 2, 2012
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3N0D
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3MXX
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1JEY
| Crystal Structure of the Ku heterodimer bound to DNA | Descriptor: | DNA (34-MER), DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*GP*GP*GP*CP*GP*CP*G)-3'), Ku70, ... | Authors: | Walker, J.R, Corpina, R.A, Goldberg, J. | Deposit date: | 2001-06-19 | Release date: | 2001-08-10 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature, 412, 2001
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2RK3
| Structure of A104T DJ-1 | Descriptor: | Protein DJ-1 | Authors: | Lakshminarasimhan, M, Maldonado, M.T, Zhou, W, Fink, A.L, Wilson, M.A. | Deposit date: | 2007-10-16 | Release date: | 2008-01-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1. Biochemistry, 47, 2008
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2RK6
| Structure of E163K DJ-1 | Descriptor: | Protein DJ-1 | Authors: | Lakshminarasimhan, M, Maldonado, M.T, Zhou, W, Fink, A.L, Wilson, M.A. | Deposit date: | 2007-10-16 | Release date: | 2008-01-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1. Biochemistry, 47, 2008
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4HC9
| DNA binding by GATA transcription factor-complex 3 | Descriptor: | DNA (5'-D(*AP*AP*GP*GP*TP*TP*AP*TP*CP*TP*CP*TP*GP*AP*TP*TP*TP*AP*GP*G)-3'), DNA (5'-D(*TP*TP*CP*CP*TP*AP*AP*AP*TP*CP*AP*GP*AP*GP*AP*TP*AP*AP*CP*C)-3'), Trans-acting T-cell-specific transcription factor GATA-3, ... | Authors: | Chen, Y, Bates, D.L, Dey, R, Chen, L. | Deposit date: | 2012-09-28 | Release date: | 2012-12-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | DNA Binding by GATA Transcription Factor Suggests Mechanisms of DNA Looping and Long-Range Gene Regulation. Cell Rep, 2, 2012
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3FJI
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1FV5
| SOLUTION STRUCTURE OF THE FIRST ZINC FINGER FROM THE DROSOPHILA U-SHAPED TRANSCRIPTION FACTOR | Descriptor: | FIRST ZINC FINGER OF U-SHAPED, ZINC ION | Authors: | Liew, C.K, Kowalski, K, Fox, A.H, Newton, A, Sharpe, B.K, Crossley, M, Mackay, J.P. | Deposit date: | 2000-09-18 | Release date: | 2000-10-04 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structures of two CCHC zinc fingers from the FOG family protein U-shaped that mediate protein-protein interactions. Structure Fold.Des., 8, 2000
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7WT1
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7WSZ
| human glyoxalase I (with C-ter His tag) in glycerol-bound form | Descriptor: | BETA-MERCAPTOETHANOL, BORIC ACID, GLYCEROL, ... | Authors: | Usami, M, Ando, K, Yokoyama, H. | Deposit date: | 2022-02-03 | Release date: | 2022-04-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Crystal structures of human glyoxalase I and its complex with TLSC702 reveal inhibitor binding mode and substrate preference. Febs Lett., 596, 2022
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7WT0
| human glyoxalase I (with C-ter His tag) in complex with TLSC702 | Descriptor: | (~{E})-3-(1,3-benzothiazol-2-yl)-4-(4-methoxyphenyl)but-3-enoic acid, Lactoylglutathione lyase, ZINC ION | Authors: | Usami, M, Yokoyama, H. | Deposit date: | 2022-02-03 | Release date: | 2022-04-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of human glyoxalase I and its complex with TLSC702 reveal inhibitor binding mode and substrate preference. Febs Lett., 596, 2022
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7WT2
| human glyoxalase I in complex with TLSC702 | Descriptor: | (~{E})-3-(1,3-benzothiazol-2-yl)-4-(4-methoxyphenyl)but-3-enoic acid, Lactoylglutathione lyase, ZINC ION | Authors: | Usami, M, Yokoyama, H. | Deposit date: | 2022-02-03 | Release date: | 2022-04-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of human glyoxalase I and its complex with TLSC702 reveal inhibitor binding mode and substrate preference. Febs Lett., 596, 2022
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8J9K
| Structure of basal beta-arrestin2 | Descriptor: | Beta-arrestin-2, Fab6 heavy chain, Fab6 light chain | Authors: | Maharana, J, Sarma, P, Yadav, M.K, Chami, M, Banerjee, R, Shukla, A.K. | Deposit date: | 2023-05-03 | Release date: | 2023-12-27 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Molecular insights into atypical modes of beta-arrestin interaction with seven transmembrane receptors. Science, 383, 2024
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3C9C
| Structural Basis of Histone H4 Recognition by p55 | Descriptor: | CADMIUM ION, Chromatin assembly factor 1 p55 subunit, Histone H4, ... | Authors: | Song, J.J, Garlick, J.D, Kingston, R.E. | Deposit date: | 2008-02-15 | Release date: | 2008-05-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis of histone H4 recognition by p55. Genes Dev., 22, 2008
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6ASY
| BiP-ATP2 | Descriptor: | 78 kDa glucose-regulated protein, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ... | Authors: | Liu, Q, Yang, J, Zong, Y, Columbus, L, Zhou, L. | Deposit date: | 2017-08-26 | Release date: | 2017-12-06 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s. Nat Commun, 8, 2017
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2ERE
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5JHG
| Crystal structure of the complex between the human RhoA and the DH/PH domain of human ARHGEF11 | Descriptor: | GLYCEROL, Rho guanine nucleotide exchange factor 11, Transforming protein RhoA | Authors: | Wang, R, Chen, Q, Zhang, H, Yan, Z, Li, J, Miao, L, Wang, F. | Deposit date: | 2016-04-21 | Release date: | 2017-04-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA bound with its inhibitor and ARHGEF11 To Be Published
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2ERG
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2ER8
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3FJF
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3FJE
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