3MXX

Crystal structure of WDR5 mutant (S62A)

Summary for 3MXX

• Entry DOI: 10.2210/pdb3mxx/pdb
• Related: 3N0D 3N0E
• Descriptor: WD repeat-containing protein 5 (2 entities in total)
• Functional Keywords: wdr5, wd-repeat protein 5, asp-his-ser-trp tetrad, thermostability, circular dichroism, folding energy, guanidine hydrochloride, transcription
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P61964
• Total number of polymer chains: 1
• Total formula weight: 34612.23

Authors

Wu, Y.-D.,Wu, X.-H.,Gao, Y.,Chen, R.-C. (deposition date: 2010-05-08, release date: 2010-10-20, Last modification date: 2023-11-01)

• Primary citation: Wu, X.-H.,Chen, R.-C.,Gao, Y.,Wu, Y.-D.; The Effect of Asp-His-Ser/Thr-Trp Tetrad on the Thermostability of WD40-Repeat Proteins; Biochemistry, 49:10237-10245, 2010; PubMed: 20939513; DOI: 10.1021/bi101321y

Experimental method

X-RAY DIFFRACTION (2.05 Å)