4JXS
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4JXG
| Crystal Structure of AmpC beta-lactamase from E. coli in Complex with Oxacillin | Descriptor: | (2R,4S)-5,5-dimethyl-2-[(1R)-1-{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino}-2-oxoethyl]-1,3-thiazolidine-4-carb oxylic acid, Beta-lactamase, PHOSPHATE ION, ... | Authors: | Wallar, B.J, Powers, R.A, Docter, B.E. | Deposit date: | 2013-03-28 | Release date: | 2014-10-29 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Complexed structures of AmpC beta-lactamase To be Published
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4JPM
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4JLF
| Inhibitor resistant (R220A) substitution in the Mycobacterium tuberculosis beta-lactamase | Descriptor: | Beta-lactamase, PHOSPHATE ION | Authors: | Hazra, S, Kurz, S, Blanchard, J, Bonomo, R. | Deposit date: | 2013-03-12 | Release date: | 2013-10-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Can inhibitor-resistant substitutions in the Mycobacterium tuberculosis beta-Lactamase BlaC lead to clavulanate resistance?: a biochemical rationale for the use of beta-lactam-beta-lactamase inhibitor combinations. Antimicrob.Agents Chemother., 57, 2013
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4IVK
| Crystal structure of a fammily VIII carboxylesterase in a complex with cephalothin. | Descriptor: | CEPHALOTHIN GROUP, Carboxylesterases, SULFATE ION | Authors: | An, Y.J, Kim, M.-K, Jeong, C.-S, Cha, S.-S. | Deposit date: | 2013-01-23 | Release date: | 2013-06-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for the beta-lactamase activity of EstU1, a family VIII carboxylesterase. Proteins, 81, 2013
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4IVI
| Crystal structure of a family VIII carboxylesterase. | Descriptor: | Carboxylesterase, SULFATE ION | Authors: | An, Y.J, Kim, M.-K, Jeong, C.-S, Cha, S.-S. | Deposit date: | 2013-01-23 | Release date: | 2013-06-19 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for the beta-lactamase activity of EstU1, a family VIII carboxylesterase. Proteins, 81, 2013
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4ID4
| Crystal structure of chimeric beta-lactamase cTEM-17m | Descriptor: | Beta-lactamase TEM, Beta-lactamase PSE-4, CHLORIDE ION, ... | Authors: | Park, J, Gobeil, S, Pelletier, J.N, Berghuis, A.M. | Deposit date: | 2012-12-11 | Release date: | 2013-12-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Maintenance of Native-like Protein Dynamics May Not Be Required for Engineering Functional Proteins. Chem.Biol., 21, 2014
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4IBX
| Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-lactamase TEM, CALCIUM ION, ... | Authors: | Dellus-Gur, E, Toth-Petroczy, A, Elias, M, Tawfik, D.S. | Deposit date: | 2012-12-09 | Release date: | 2013-04-03 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | What Makes a Protein Fold Amenable to Functional Innovation? Fold Polarity and Stability Trade-offs. J.Mol.Biol., 425, 2013
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4IBR
| Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying G238S/E104K mutations | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, TEM-94 ES-beta-lactamase | Authors: | Dellus-Gur, E, Toth-Petroczy, A, Elias, M, Tawfik, D.S. | Deposit date: | 2012-12-09 | Release date: | 2013-04-03 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | What Makes a Protein Fold Amenable to Functional Innovation? Fold Polarity and Stability Trade-offs. J.Mol.Biol., 425, 2013
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4HEF
| Structure of avibactam bound to Pseudomonas aeruginosa AmpC | Descriptor: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase, GLYCEROL | Authors: | Lahiri, S.D. | Deposit date: | 2012-10-03 | Release date: | 2013-06-05 | Last modified: | 2020-09-16 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structural Insight into Potent Broad-Spectrum Inhibition with Reversible Recyclization Mechanism: Avibactam in Complex with CTX-M-15 and Pseudomonas aeruginosa AmpC beta-Lactamases Antimicrob.Agents Chemother., 57, 2013
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4HBU
| Crystal structure of CTX-M-15 extended-spectrum beta-lactamase in complex with avibactam (NXL104) | Descriptor: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, 1,2-ETHANEDIOL, Beta-lactamase, ... | Authors: | Docquier, J.D, Benvenuti, M, Bruneau, J.M, Rossolini, G.M, Miossec, C, Black, M.T, Mangani, S. | Deposit date: | 2012-09-28 | Release date: | 2013-04-10 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Structural insight into potent broad-spectrum inhibition with reversible recyclization mechanism: avibactam in complex with CTX-M-15 and Pseudomonas aeruginosa AmpC beta-lactamases Antimicrob.Agents Chemother., 57, 2013
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4HBT
| Crystal structure of native CTX-M-15 extended-spectrum beta-lactamase | Descriptor: | 1,2-ETHANEDIOL, Beta-lactamase, CHLORIDE ION, ... | Authors: | Docquier, J.D, Benvenuti, M, Bruneau, J.M, Rossolini, G.M, Miossec, C, Black, M.T, Mangani, S. | Deposit date: | 2012-09-28 | Release date: | 2013-04-10 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Structural insight into potent broad-spectrum inhibition with reversible recyclization mechanism: avibactam in complex with CTX-M-15 and Pseudomonas aeruginosa AmpC beta-lactamases Antimicrob.Agents Chemother., 57, 2013
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4H8R
| Imipenem complex of GES-5 carbapenemase | Descriptor: | (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, Extended-spectrum beta-lactamase GES-5, IODIDE ION, ... | Authors: | Smith, C.A, Vakulenko, S.B. | Deposit date: | 2012-09-23 | Release date: | 2013-07-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Structural basis for progression toward the carbapenemase activity in the GES family of beta-lactamases. J.Am.Chem.Soc., 134, 2012
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4GZB
| Crystal structure of native AmpC beta-lactamase from Pseudomonas aeruginosa PAO1 | Descriptor: | 1,2-ETHANEDIOL, Beta-lactamase | Authors: | Benvenuti, M, De Luca, F, Docquier, J.D, Mangani, S. | Deposit date: | 2012-09-06 | Release date: | 2013-04-10 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Structural insight into potent broad-spectrum inhibition with reversible recyclization mechanism: avibactam in complex with CTX-M-15 and Pseudomonas aeruginosa AmpC beta-lactamases Antimicrob.Agents Chemother., 57, 2013
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4GOG
| Crystal structure of the GES-1 imipenem acyl-enzyme complex | Descriptor: | (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase GES-1, IODIDE ION, ... | Authors: | Smith, C.A, Vakulenko, S.B, Munoz, J. | Deposit date: | 2012-08-20 | Release date: | 2013-07-24 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Structural basis for progression toward the carbapenemase activity in the GES family of beta-lactamases. J.Am.Chem.Soc., 134, 2012
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4GNU
| Crystal structure of GES-5 carbapenemase | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-lactamase GES-5 | Authors: | Smith, C.A, Vakulenko, S.B. | Deposit date: | 2012-08-17 | Release date: | 2013-07-24 | Method: | X-RAY DIFFRACTION (1.09 Å) | Cite: | Structural basis for progression toward the carbapenemase activity in the GES family of beta-lactamases. J.Am.Chem.Soc., 134, 2012
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4GKU
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4GDN
| Structure of FmtA-like protein | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Protein flp | Authors: | Cougnoux, A, Gibold, L, Delmas, J, Robin, F, Dalmasso, G, Bonnet, R. | Deposit date: | 2012-08-01 | Release date: | 2012-10-03 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Analysis of Structure-Function Relationships in the Colibactin-Maturating Enzyme ClbP. J.Mol.Biol., 424, 2012
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4GDB
| SHV-1 in complex with 4H-pyrazolo[1,5-c][1,3]thiazole containing penem inhibitor | Descriptor: | (7R)-6-formyl-7-(4H-pyrazolo[1,5-c][1,3]thiazol-2-yl)-4,7-dihydro-1,4-thiazepine-3-carboxylic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-lactamase SHV-1, ... | Authors: | Ke, W, van den Akker, F. | Deposit date: | 2012-07-31 | Release date: | 2013-07-31 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Structures of SHV-1 beta-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation Plos One, 7, 2012
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4GD8
| SHV-1 beta-lactamase in complex with penam sulfone SA3-53 | Descriptor: | (2S,3R)-4-(2-aminoethylcarbamoyloxy)-2-[(2-methanoylindolizin-3-yl)amino]-3-methyl-3-sulfino-butanoic acid, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE | Authors: | Pattanaik, P, van den Akker, F. | Deposit date: | 2012-07-31 | Release date: | 2013-07-31 | Last modified: | 2013-08-07 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structures of SHV-1 beta-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation Plos One, 7, 2012
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4GD6
| SHV-1 beta-lactamase in complex with penam sulfone SA1-204 | Descriptor: | (3R)-N-(2-formylindolizin-3-yl)-4-[(phenylacetyl)oxy]-3-sulfino-D-valine, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE | Authors: | van den Akker, F, Wei, K. | Deposit date: | 2012-07-31 | Release date: | 2013-07-31 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Structures of SHV-1 beta-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation Plos One, 7, 2012
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4GB7
| Putative 6-aminohexanoate-dimer hydrolase from Bacillus anthracis | Descriptor: | 1,2-ETHANEDIOL, 6-aminohexanoate-dimer hydrolase, NITRATE ION | Authors: | Osipiuk, J, Zhou, M, Kwon, K, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2012-07-26 | Release date: | 2012-08-08 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Putative 6-aminohexanoate-dimer hydrolase from Bacillus anthracis. To be Published
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4FH4
| high-resolution structure of apo wt SHV-1 beta-lactamase | Descriptor: | Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE | Authors: | Rodkey, E.A, van den Akker, F. | Deposit date: | 2012-06-05 | Release date: | 2012-09-26 | Last modified: | 2013-07-24 | Method: | X-RAY DIFFRACTION (1.09 Å) | Cite: | Crystal structure of a pre-acylation complex of the beta-lactamase inhibitor, sulbactam, bound to a sulfenamide bond containing thiol-beta-lactamase J.Am.Chem.Soc., 134, 2012
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4FH2
| Structure of s70c beta-lactamase bound to sulbactam | Descriptor: | Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, SULBACTAM | Authors: | Rodkey, E.A, van den Akker, F. | Deposit date: | 2012-06-05 | Release date: | 2012-09-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Crystal structure of a pre-acylation complex of the beta-lactamase inhibitor, sulbactam, bound to a sulfenamide bond containing thiol-beta-lactamase J.Am.Chem.Soc., 134, 2012
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4FD8
| Structure of apo S70C SHV beta-lactamase | Descriptor: | Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE | Authors: | Rodkey, E.A, van den Akker, F. | Deposit date: | 2012-05-26 | Release date: | 2012-09-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Crystal structure of a pre-acylation complex of the beta-lactamase inhibitor, sulbactam, bound to a sulfenamide bond containing thiol-beta-lactamase J.Am.Chem.Soc., 134, 2012
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