4JPM
Structure of SHV-1 beta-lactamase in complex with the 7-alkylidenecephalosporin DCM-1-10 at 1.14 Ang resolution
Summary for 4JPM
Entry DOI | 10.2210/pdb4jpm/pdb |
Related | 4FH4 |
Descriptor | Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, 7-alkylidenecephalosporin DCM-1-10, bound form, ... (5 entities in total) |
Functional Keywords | class a beta-lactamase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 32918.90 |
Authors | Rodkey, E.A.,van den Akker, F. (deposition date: 2013-03-19, release date: 2013-12-04, Last modification date: 2023-09-20) |
Primary citation | Rodkey, E.A.,McLeod, D.C.,Bethel, C.R.,Smith, K.M.,Xu, Y.,Chai, W.,Che, T.,Carey, P.R.,Bonomo, R.A.,van den Akker, F.,Buynak, J.D. beta-Lactamase Inhibition by 7-Alkylidenecephalosporin Sulfones: Allylic Transposition and Formation of an Unprecedented Stabilized Acyl-Enzyme. J.Am.Chem.Soc., 135:18358-18369, 2013 Cited by PubMed: 24219313DOI: 10.1021/ja403598g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.14 Å) |
Structure validation
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