4GOG

Crystal structure of the GES-1 imipenem acyl-enzyme complex

Summary for 4GOG

• Entry DOI: 10.2210/pdb4gog/pdb
• Related: 4GNU 4H8R
• Descriptor: Beta-lactamase GES-1, (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid, IODIDE ION, ... (5 entities in total)
• Functional Keywords: beta-lactamase, carbapenemase, imipenem, hydrolase-antibiotic complex, hydrolase/antibiotic
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 2
• Total formula weight: 65444.76

Authors

Smith, C.A.,Vakulenko, S.B.,Munoz, J. (deposition date: 2012-08-20, release date: 2013-07-24)

• Primary citation: Smith, C.A.,Frase, H.,Toth, M.,Kumarasiri, M.,Wiafe, K.,Munoz, J.,Mobashery, S.,Vakulenko, S.B.; Structural basis for progression toward the carbapenemase activity in the GES family of beta-lactamases.; J.Am.Chem.Soc., 134:19512-19515, 2012; PubMed: 23148776; DOI: 10.1021/ja308197j

Experimental method

X-RAY DIFFRACTION (1.1 Å)