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4HBT

Crystal structure of native CTX-M-15 extended-spectrum beta-lactamase

Summary for 4HBT
Entry DOI10.2210/pdb4hbt/pdb
Related4GZB 4HBU 4HEF
DescriptorBeta-lactamase, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordshydrolysis of beta-lactams, antibiotic resistance, hydrolase
Biological sourceEscherichia coli
Total number of polymer chains1
Total formula weight29151.14
Authors
Docquier, J.D.,Benvenuti, M.,Bruneau, J.M.,Rossolini, G.M.,Miossec, C.,Black, M.T.,Mangani, S. (deposition date: 2012-09-28, release date: 2013-04-10, Last modification date: 2023-11-08)
Primary citationLahiri, S.D.,Mangani, S.,Durand-Reville, T.,Benvenuti, M.,De Luca, F.,Sanyal, G.,Docquier, J.D.
Structural insight into potent broad-spectrum inhibition with reversible recyclization mechanism: avibactam in complex with CTX-M-15 and Pseudomonas aeruginosa AmpC beta-lactamases
Antimicrob.Agents Chemother., 57:2496-2505, 2013
Cited by
PubMed: 23439634
DOI: 10.1128/AAC.02247-12
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.1 Å)
Structure validation

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