Crystal structure of native CTX-M-15 extended-spectrum beta-lactamase

Summary for 4HBT

Related4GZB 4HBU 4HEF
DescriptorBeta-lactamase, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordshydrolysis of beta-lactams, antibiotic resistance, hydrolase
Biological sourceEscherichia coli
Total number of polymer chains1
Total molecular weight29151.14
Docquier, J.D.,Benvenuti, M.,Bruneau, J.M.,Rossolini, G.M.,Miossec, C.,Black, M.T.,Mangani, S. (deposition date: 2012-09-28, release date: 2013-04-10, Last modification date: 2019-12-04)
Primary citation
Lahiri, S.D.,Mangani, S.,Durand-Reville, T.,Benvenuti, M.,De Luca, F.,Sanyal, G.,Docquier, J.D.
Structural insight into potent broad-spectrum inhibition with reversible recyclization mechanism: avibactam in complex with CTX-M-15 and Pseudomonas aeruginosa AmpC beta-lactamases
Antimicrob.Agents Chemother., 57:2496-2505, 2013
PubMed: 23439634 (PDB entries with the same primary citation)
DOI: 10.1128/AAC.02247-12
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.1452 0.4% 1.0% 3.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-21