PDB: 35140 resultsInfo pagesStatus searchChemie searchBIRD

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8RPP	Crystal structure of the JIP1-JIP2-SH3 heterodimer and the JIP2-JIP2-SH3 homodimer Descriptor: C-Jun-amino-terminal kinase-interacting protein 1, C-Jun-amino-terminal kinase-interacting protein 2 Authors: Palencia, A, Marino-Perez, L, Ielasi, F.I, Jensen, M.R. Deposit date: 2024-01-16 Release date: 2024-07-10 Method: X-RAY DIFFRACTION (1.867 Å) Cite: Structural basis of homodimerization of the JNK scaffold protein JIP2 and its heterodimerization with JIP1 Structure, 2024
7A00	Crystal structure of Shank1 PDZ in complex with L6F mutant of the C-terminal hexapeptide from GKAP Descriptor: L6F mutant of C-terminal hexapeptide from Guanylate kinase-associated protein, SH3 and multiple ankyrin repeat domains protein 1 Authors: Zsofia, H, Hetherington, K, Fruzsina, H, Edwards, T.A, Wilson, A.J. Deposit date: 2020-08-05 Release date: 2021-07-07 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Query-guided protein-protein interaction inhibitor discovery. Chem Sci, 12, 2021
9FMD	Integrative model of the human post-catalytic spliceosome (P-complex) Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... Authors: Rothe, P, Plaschka, C, Vorlaender, M.K. Deposit date: 2024-06-05 Release date: 2024-07-10 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Mechanism for the initiation of spliceosome disassembly. Nature, 2024
8HEY	One CVSC-binding penton vertex in HCMV B-capsid Descriptor: Capsid vertex component 1, Capsid vertex component 2, Major capsid protein, ... Authors: Li, Z, Yu, X. Deposit date: 2022-11-09 Release date: 2023-11-01 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Cryo-electron microscopy structures of capsids and in situ portals of DNA-devoid capsids of human cytomegalovirus. Nat Commun, 14, 2023
8HEX	C5 portal vertex in HCMV B-capsid Descriptor: Capsid vertex component 1, Capsid vertex component 2, Major capsid protein, ... Authors: Li, Z, Yu, X. Deposit date: 2022-11-08 Release date: 2023-11-01 Method: ELECTRON MICROSCOPY (4 Å) Cite: Cryo-electron microscopy structures of capsids and in situ portals of DNA-devoid capsids of human cytomegalovirus. Nat Commun, 14, 2023
4R14	Crystal structure of human CSN6 MPN domain Descriptor: COP9 signalosome complex subunit 6, MERCURY (II) ION Authors: Jiang, T, Xu, M, Ma, X.L. Deposit date: 2014-08-04 Release date: 2014-10-22 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.601 Å) Cite: Crystal structure of the human CSN6 MPN domain Biochem.Biophys.Res.Commun., 453, 2014
8IGC	Crystal structure of Bak bound to Bnip5 BH3 Descriptor: Bcl-2 homologous antagonist/killer, Protein BNIP5 Authors: Ku, B, Lim, D. Deposit date: 2023-02-20 Release date: 2023-09-20 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.697 Å) Cite: Crystal structure of Bak bound to the BH3 domain of Bnip5, a noncanonical BH3 domain-containing protein. Proteins, 92, 2024
4R3C	Crystal structure of p38 alpha MAP kinase in complex with a novel isoform selective drug candidate Descriptor: 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, 6-(4-methylpiperazin-1-yl)-3-(naphthalen-2-yl)-4-(pyridin-4-yl)pyridazine, CHLORIDE ION, ... Authors: Grum-Tokars, V.L, Minasov, G, Roy, S.M, Anderson, W.F, Watterson, D.M. Deposit date: 2014-08-14 Release date: 2015-02-25 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (2.06 Å) Cite: Targeting human central nervous system protein kinases: An isoform selective p38 alpha MAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models. ACS Chem Neurosci, 6, 2015
8ENK	Crystal structure of UAP56 in complex with Tho1, the yeast homolog of human SARNP Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... Authors: Xie, Y, Ren, Y. Deposit date: 2022-09-30 Release date: 2023-08-16 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly. Cell Rep, 42, 2023
3KJ0	Mcl-1 in complex with Bim BH3 mutant I2dY Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1 Authors: Fire, E, Grant, R.A, Keating, A.E. Deposit date: 2009-11-02 Release date: 2010-02-16 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes. Protein Sci., 19, 2010
3KJ1	Mcl-1 in complex with Bim BH3 mutant I2dA Descriptor: ACETATE ION, Bcl-2-like protein 11, CHLORIDE ION, ... Authors: Fire, E, Grant, R.A, Keating, A.E. Deposit date: 2009-11-02 Release date: 2010-02-16 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.945 Å) Cite: Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes. Protein Sci., 19, 2010
8DHB	Active FLCN GAP complex Descriptor: BERYLLIUM TRIFLUORIDE ION, Folliculin, Folliculin-interacting protein 2, ... Authors: Jansen, R.M, Hurley, J.H. Deposit date: 2022-06-25 Release date: 2022-09-28 Method: ELECTRON MICROSCOPY (3.53 Å) Cite: Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation. Sci Adv, 8, 2022
8I3E	Crystal structure of ELKS1 in complex with Piccolo Descriptor: ELKS/Rab6-interacting/CAST family member 1, MKIAA0559 protein Authors: Cai, Q, Zhang, M. Deposit date: 2023-01-17 Release date: 2024-01-24 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Short-distance vesicle transport via phase separation. Cell, 187, 2024
3KJ2	Mcl-1 in complex with Bim BH3 mutant F4aE Descriptor: ACETATE ION, Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ... Authors: Fire, E, Grant, R.A, Keating, A.E. Deposit date: 2009-11-02 Release date: 2010-02-16 Last modified: 2021-10-13 Method: X-RAY DIFFRACTION (2.351 Å) Cite: Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes. Protein Sci., 19, 2010
4RJF	Crystal structure of the human sliding clamp at 2.0 angstrom resolution Descriptor: Cyclin-dependent kinase inhibitor 1, Proliferating cell nuclear antigen Authors: Kroker, A.J, Bruning, J.B. Deposit date: 2014-10-09 Release date: 2015-08-26 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.0072 Å) Cite: p21 Exploits Residue Tyr151 as a Tether for High-Affinity PCNA Binding. Biochemistry, 54, 2015
6FQP	Crystal structure of TALE homeobox domain transcription factor TGIF1 with its consensus DNA Descriptor: CALCIUM ION, DNA (5'-D(P*AP*TP*TP*GP*AP*CP*AP*GP*CP*TP*GP*TP*CP*AP*AP*T)-3'), Homeobox protein TGIF1 Authors: Guca, E, Macias, M.J. Deposit date: 2018-02-14 Release date: 2018-07-25 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.42 Å) Cite: TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-beta signaling. Nucleic Acids Res., 46, 2018
6FQQ	Crystal structure of TALE homeobox domain transcription factor TGIF1 double alanine mutant bound to its consensus DNA Descriptor: CHLORIDE ION, DNA (5'-D(P*AP*TP*TP*GP*AP*CP*AP*GP*CP*TP*GP*TP*CP*AP*AP*T)-3'), Homeobox protein TGIF1 Authors: Guca, E, Macias, M.J. Deposit date: 2018-02-14 Release date: 2018-07-25 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.25000262 Å) Cite: TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-beta signaling. Nucleic Acids Res., 46, 2018
8JE2	Cryo-EM structure of neddylated Cul2-Rbx1-EloBC-FEM1B complexed with FNIP1-FLCN Descriptor: Cullin-2, Elongin-B, Elongin-C, ... Authors: Dai, Z, Liang, L, Yin, Y.X. Deposit date: 2023-05-15 Release date: 2024-02-28 Last modified: 2024-04-03 Method: ELECTRON MICROSCOPY (3.63 Å) Cite: Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase. Embo J., 43, 2024
6FG7	Crystal structure of the BIR2 ectodomain from Arabidopsis thaliana. Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Inactive LRR receptor-like serine/threonine-protein kinase BIR2, ... Authors: Hothorn, M, Hohmann, U. Deposit date: 2018-01-10 Release date: 2018-01-24 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The SERK3 elongated allele defines a role for BIR ectodomains in brassinosteroid signalling. Nat Plants, 4, 2018
4M6R	Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme Descriptor: Methylthioribulose-1-phosphate dehydratase, ZINC ION Authors: Kang, W, Hong, S.H, Lee, H.M, Kim, N.Y, Lim, Y.C, Le, L.T.M, Lim, B, Kim, H.C, Kim, T.Y, Ashida, H, Yokota, A, Hah, S.S, Chun, K.H, Jung, Y.K, Yang, J.K. Deposit date: 2013-08-10 Release date: 2014-01-29 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme. Proc.Natl.Acad.Sci.USA, 111, 2014
6WJ3	CryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the post-GAP state Descriptor: GUANOSINE-5'-DIPHOSPHATE, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ... Authors: Fromm, S.A, Hurley, J.H. Deposit date: 2020-04-11 Release date: 2020-09-02 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9. Nat.Struct.Mol.Biol., 27, 2020
4KP3	Crystal Structure of MyoVa-GTD in Complex with Two Cargos Descriptor: Melanophilin, RILP-like protein 2, Unconventional myosin-Va Authors: Wei, Z, Liu, X, Yu, C, Zhang, M. Deposit date: 2013-05-13 Release date: 2013-07-10 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.405 Å) Cite: Structural basis of cargo recognitions for class V myosins Proc.Natl.Acad.Sci.USA, 110, 2013
5RJP	PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with NCL-00024672 Descriptor: 4-bromo-1-(2-hydroxyethyl)pyridin-2(1H)-one, PH-interacting protein Authors: Grosjean, H, Aimon, A, Krojer, T, Talon, R, Douangamath, A, Koekemoer, L, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Biggin, P.C. Deposit date: 2020-06-02 Release date: 2020-06-17 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.242 Å) Cite: PanDDA analysis group deposition of ground-state model To Be Published
5RK3	PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z1501469697 Descriptor: 3-amino-1,6-dimethylpyridin-2(1H)-one, PH-interacting protein Authors: Grosjean, H, Aimon, A, Krojer, T, Talon, R, Douangamath, A, Koekemoer, L, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Biggin, P.C. Deposit date: 2020-06-02 Release date: 2020-06-17 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.31 Å) Cite: PanDDA analysis group deposition of ground-state model To Be Published
5RKN	PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z373768900 Descriptor: N-(1-ethyl-1H-pyrazol-4-yl)cyclobutanecarboxamide, PH-interacting protein Authors: Grosjean, H, Aimon, A, Krojer, T, Talon, R, Douangamath, A, Koekemoer, L, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Biggin, P.C. Deposit date: 2020-06-02 Release date: 2020-06-17 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.23 Å) Cite: PanDDA analysis group deposition of ground-state model To Be Published

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