6FQQ
Crystal structure of TALE homeobox domain transcription factor TGIF1 double alanine mutant bound to its consensus DNA
Summary for 6FQQ
Entry DOI | 10.2210/pdb6fqq/pdb |
Related | 6FQP |
Descriptor | Homeobox protein TGIF1, DNA (5'-D(P*AP*TP*TP*GP*AP*CP*AP*GP*CP*TP*GP*TP*CP*AP*AP*T)-3'), CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | homeobox, three-amino acid loop extension, tgf-beta pathway, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 52910.36 |
Authors | Guca, E.,Macias, M.J. (deposition date: 2018-02-14, release date: 2018-07-25, Last modification date: 2024-01-17) |
Primary citation | Guca, E.,Sunol, D.,Ruiz, L.,Konkol, A.,Cordero, J.,Torner, C.,Aragon, E.,Martin-Malpartida, P.,Riera, A.,Macias, M.J. TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-beta signaling. Nucleic Acids Res., 46:9220-9235, 2018 Cited by PubMed: 30060237DOI: 10.1093/nar/gky680 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.25000253887 Å) |
Structure validation
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