6FQQ
Crystal structure of TALE homeobox domain transcription factor TGIF1 double alanine mutant bound to its consensus DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G, H (A, B, D, E) | Homeobox protein TGIF1 | polymer | 71 | 8321.5 | 4 | UniProt (Q15583) Pfam (PF05920) | Homo sapiens (Human) | 5'-TG-3'-interacting factor 1 |
| 2 | B, C, E, F (L, M, G, H) | DNA (5'-D(P*AP*TP*TP*GP*AP*CP*AP*GP*CP*TP*GP*TP*CP*AP*AP*T)-3') | polymer | 16 | 4897.2 | 4 | Homo sapiens | ||
| 3 | I (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | J, K, L, M, N... (A, L, M, B, G...) | water | water | 18.0 | 32 | Chemie (HOH) |
Sequence modifications
A, B, D, E: 161 - 229 (UniProt: Q15583)
| PDB | External Database | Details |
|---|---|---|
| Gly 159 | - | expression tag |
| Pro 160 | - | expression tag |
| Ala 167 | Arg 167 | engineered mutation |
| Ala 168 | Arg 168 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 52874.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 35.5 | |
| All* | Total formula weight | 52910.4 |
