7A00

Crystal structure of Shank1 PDZ in complex with L6F mutant of the C-terminal hexapeptide from GKAP

Summary for 7A00

Entry DOI	10.2210/pdb7a00/pdb
Descriptor	SH3 and multiple ankyrin repeat domains protein 1, L6F mutant of C-terminal hexapeptide from Guanylate kinase-associated protein (3 entities in total)
Functional Keywords	shank1 pdz, gkap, peptide binding protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	26238.26
Authors	Zsofia, H.,Hetherington, K.,Fruzsina, H.,Edwards, T.A.,Wilson, A.J. (deposition date: 2020-08-05, release date: 2021-07-07, Last modification date: 2024-01-31)
Primary citation	Celis, S.,Hobor, F.,James, T.,Bartlett, G.J.,Ibarra, A.A.,Shoemark, D.K.,Hegedus, Z.,Hetherington, K.,Woolfson, D.N.,Sessions, R.B.,Edwards, T.A.,Andrews, D.M.,Nelson, A.,Wilson, A.J. Query-guided protein-protein interaction inhibitor discovery. Chem Sci, 12:4753-4762, 2021 Cited by PubMed: 34163731 DOI: 10.1039/d1sc00023c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.78 Å)

Structure validation