6FQP

Crystal structure of TALE homeobox domain transcription factor TGIF1 with its consensus DNA

Summary for 6FQP

• Entry DOI: 10.2210/pdb6fqp/pdb
• Descriptor: DNA (5'-D(P*AP*TP*TP*GP*AP*CP*AP*GP*CP*TP*GP*TP*CP*AP*AP*T)-3'), Homeobox protein TGIF1, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: homeobox, three-amino acid loop extension, tgf-beta pathway, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 33293.16

Authors

Guca, E.,Macias, M.J. (deposition date: 2018-02-14, release date: 2018-07-25, Last modification date: 2024-01-17)

• Primary citation: Guca, E.,Sunol, D.,Ruiz, L.,Konkol, A.,Cordero, J.,Torner, C.,Aragon, E.,Martin-Malpartida, P.,Riera, A.,Macias, M.J.; TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-beta signaling.; Nucleic Acids Res., 46:9220-9235, 2018; PubMed: 30060237; DOI: 10.1093/nar/gky680

Experimental method

X-RAY DIFFRACTION (2.42 Å)