8JE2

Cryo-EM structure of neddylated Cul2-Rbx1-EloBC-FEM1B complexed with FNIP1-FLCN

Summary for 8JE2

• Entry DOI: 10.2210/pdb8je2/pdb
• EMDB information: 36183
• Descriptor: Cullin-2, Elongin-B, Elongin-C, ... (6 entities in total)
• Functional Keywords: complex, e3 ubiquitin ligase, cullin, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 312975.64

Authors

Dai, Z.,Liang, L.,Yin, Y.X. (deposition date: 2023-05-15, release date: 2024-02-28, Last modification date: 2024-04-03)

• Primary citation: Dai, Z.,Liang, L.,Wang, W.,Zuo, P.,Yu, S.,Liu, Y.,Zhao, X.,Lu, Y.,Jin, Y.,Zhang, F.,Ding, D.,Deng, W.,Yin, Y.; Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase.; Embo J., 43:1089-1109, 2024; PubMed: 38360992; DOI: 10.1038/s44318-024-00047-y

Experimental method

ELECTRON MICROSCOPY (3.63 Å)