8JE2
Cryo-EM structure of neddylated Cul2-Rbx1-EloBC-FEM1B complexed with FNIP1-FLCN
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cullin-2 | polymer | 751 | 87927.8 | 1 | UniProt (Q13617) Pfam (PF00888) Pfam (PF26557) Pfam (PF10557) | Homo sapiens (human) | CUL-2 |
| 2 | B (B) | Elongin-B | polymer | 104 | 11748.4 | 1 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 3 | C (C) | Elongin-C | polymer | 98 | 11045.7 | 1 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 4 | D (D) | Protein fem-1 homolog B | polymer | 630 | 70688.4 | 1 | UniProt (Q9UK73) Pfam (PF12796) | Homo sapiens (human) | FEM1b,FEM1-beta,Fem-1-like death receptor-binding protein alpha,Fem-1-like in apoptotic pathway protein alpha,F1A-alpha |
| 5 | E (H) | Folliculin-interacting protein 1 | polymer | 1172 | 131499.9 | 1 | UniProt (Q8TF40) Pfam (PF14637) Pfam (PF14638) Pfam (PF14636) | Homo sapiens (human) | |
| 6 | F (D) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A: 1 - 745 (UniProt: Q13617)
C: 16 - 112 (UniProt: Q15369)
D: 1 - 627 (UniProt: Q9UK73)
H: -27 - 1138 (UniProt: Q8TF40)
| PDB | External Database | Details |
|---|---|---|
| His 746 | - | expression tag |
| His 747 | - | expression tag |
| His 748 | - | expression tag |
| His 749 | - | expression tag |
| His 750 | - | expression tag |
| His 751 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 15 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Glu -1 | - | expression tag |
| Phe 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Glu 1139 | - | expression tag |
| Asn 1140 | - | expression tag |
| Leu 1141 | - | expression tag |
| Tyr 1142 | - | expression tag |
| Phe 1143 | - | expression tag |
| Gln 1144 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 312910.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 312975.6 |
