2LAS
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![BU of 2las by Molmil](/molmil-images/mine/2las) | Molecular Determinants of Paralogue-Specific SUMO-SIM Recognition | Descriptor: | M-IR2_peptide, Small ubiquitin-related modifier 1 | Authors: | Namanja, A, Li, Y, Su, Y, Wong, S, Lu, J, Colson, L, Wu, C, Li, S, Chen, Y. | Deposit date: | 2011-03-20 | Release date: | 2011-12-14 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Insights into High Affinity Small Ubiquitin-like Modifier (SUMO) Recognition by SUMO-interacting Motifs (SIMs) Revealed by a Combination of NMR and Peptide Array Analysis. J.Biol.Chem., 287, 2012
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2IYD
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![BU of 2iyd by Molmil](/molmil-images/mine/2iyd) | SENP1 covalent complex with SUMO-2 | Descriptor: | SENTRIN-SPECIFIC PROTEASE 1, SMALL UBIQUITIN-RELATED MODIFIER 2 | Authors: | Dong, C, Naismith, J.H. | Deposit date: | 2006-07-14 | Release date: | 2006-08-08 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Senp1 Native Structure To be Published
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2IO3
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![BU of 2io3 by Molmil](/molmil-images/mine/2io3) | Crystal structure of human Senp2 in complex with RanGAP1-SUMO-2 | Descriptor: | Ran GTPase-activating protein 1, Sentrin-specific protease 2, Small ubiquitin-related modifier 2 | Authors: | Reverter, D, Lima, C.D. | Deposit date: | 2006-10-09 | Release date: | 2006-11-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates. Nat.Struct.Mol.Biol., 13, 2006
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4BKG
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![BU of 4bkg by Molmil](/molmil-images/mine/4bkg) | crystal structure of human diSUMO-2 | Descriptor: | SMALL UBIQUITIN-RELATED MODIFIER 2 | Authors: | Keusekotten, K, Bade, V.N, Meyer-Teschendorf, K, Sriramachandran, A, Fischer-Schrader, K, Krause, A, Horst, C, Hofmann, K, Dohmen, R.J, Praefcke, G.J.K. | Deposit date: | 2013-04-25 | Release date: | 2013-11-06 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Multivalent Interactions of the Sumo-Interaction Motifs in the Ring-Finger Protein 4 (Rnf4) Determine the Specificity for Chains of the Small Ubiquitin-Related Modifier (Sumo). Biochem.J., 457, 2014
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7ZJU
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![BU of 7zju by Molmil](/molmil-images/mine/7zju) | |
2IO0
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![BU of 2io0 by Molmil](/molmil-images/mine/2io0) | Crystal structure of human Senp2 in complex with preSUMO-2 | Descriptor: | SULFATE ION, Sentrin-specific protease 2, Small ubiquitin-related modifier 2 precursor | Authors: | Reverter, D, Lima, C.D. | Deposit date: | 2006-10-09 | Release date: | 2006-11-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates. Nat.Struct.Mol.Biol., 13, 2006
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6K5R
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![BU of 6k5r by Molmil](/molmil-images/mine/6k5r) | Complex of SUMO2 with Phosphorylated viral SIM IE2 | Descriptor: | ASP-THR-ALA-GLY-CYS-ILE-VAL-ILE-SEP-ASP-SEP-GLU, Small ubiquitin-related modifier 3 | Authors: | Chatterjee, K.S, Das, R. | Deposit date: | 2019-05-30 | Release date: | 2019-08-07 | Last modified: | 2019-12-25 | Method: | SOLUTION NMR | Cite: | Casein kinase-2-mediated phosphorylation increases the SUMO-dependent activity of the cytomegalovirus transactivator IE2. J.Biol.Chem., 294, 2019
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5EQL
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![BU of 5eql by Molmil](/molmil-images/mine/5eql) | Isoform-specific inhibition of SUMO-dependent protein-protein interactions | Descriptor: | SUMO-Affirmer-S2D5, Small ubiquitin-related modifier 2 | Authors: | Hughes, D.J, Tiede, C, Hall, N, Tang, A.A.S, Trinh, C.H, Zajac, K, Mandal, U, Howell, G, Edwards, T.A, McPherson, M.J, Tomlinson, D.C, Whitehouse, A. | Deposit date: | 2015-11-13 | Release date: | 2016-11-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology. Sci Signal, 10, 2017
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5ELU
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![BU of 5elu by Molmil](/molmil-images/mine/5elu) | Isoform-specific inhibition of SUMO-dependent protein-protein interactions | Descriptor: | SULFATE ION, SUMO-Affirmer-S2B3, Small ubiquitin-related modifier 2 | Authors: | Hughes, D.J, Tiede, C, Hall, N, Tang, A.A.S, Trinh, C.H, Zajac, K, Mandal, U, Howell, G, Edwards, T.A, McPherson, M.J, Tomlinson, D.C, Whitehouse, A. | Deposit date: | 2015-11-05 | Release date: | 2016-11-16 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology. Sci Signal, 10, 2017
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6Z2K
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![BU of 6z2k by Molmil](/molmil-images/mine/6z2k) | The structure of the tetrameric HDAC1/MIDEAS/DNTTIP1 MiDAC deacetylase complex | Descriptor: | Deoxynucleotidyltransferase terminal-interacting protein 1, Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Fairall, L, Saleh, A, Ragan, T.J, Millard, C.J, Savva, C.G, Schwabe, J.W.R. | Deposit date: | 2020-05-16 | Release date: | 2020-07-08 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure. Nat Commun, 11, 2020
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4FO9
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![BU of 4fo9 by Molmil](/molmil-images/mine/4fo9) | Crystal structure of the E3 SUMO Ligase PIAS2 | Descriptor: | E3 SUMO-protein ligase PIAS2, UNKNOWN ATOM OR ION, ZINC ION | Authors: | Dong, A, Hu, J, Dobrovetsky, E, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC) | Deposit date: | 2012-06-20 | Release date: | 2012-07-18 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Crystal structure of the E3 SUMO Ligase PIAS2 to be published
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4V6X
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![BU of 4v6x by Molmil](/molmil-images/mine/4v6x) | Structure of the human 80S ribosome | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | Authors: | Anger, A.M, Armache, J.-P, Berninghausen, O, Habeck, M, Subklewe, M, Wilson, D.N, Beckmann, R. | Deposit date: | 2013-02-27 | Release date: | 2014-07-09 | Last modified: | 2023-02-01 | Method: | ELECTRON MICROSCOPY (5 Å) | Cite: | Structures of the human and Drosophila 80S ribosome. Nature, 497, 2013
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8RM5
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![BU of 8rm5 by Molmil](/molmil-images/mine/8rm5) | Cryo-EM structure of the cross-exon pre-B+5'ssLNG+ATPyS complex | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'SS oligo, NHP2-like protein 1, ... | Authors: | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | Deposit date: | 2024-01-05 | Release date: | 2024-05-22 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (6.9 Å) | Cite: | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
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6Z6M
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![BU of 6z6m by Molmil](/molmil-images/mine/6z6m) | Cryo-EM structure of human 80S ribosomes bound to EBP1, eEF2 and SERBP1 | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | Authors: | Wells, J.N, Buschauer, R, Mackens-Kiani, T, Best, K, Kratzat, H, Berninghausen, O, Becker, T, Cheng, J, Beckmann, R. | Deposit date: | 2020-05-28 | Release date: | 2020-07-29 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes. Plos Biol., 18, 2020
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6Z6N
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![BU of 6z6n by Molmil](/molmil-images/mine/6z6n) | Cryo-EM structure of human EBP1-80S ribosomes (focus on EBP1) | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | Authors: | Wells, J.N, Buschauer, R, Mackens-Kiani, T, Best, K, Kratzat, H, Berninghausen, O, Becker, T, Cheng, J, Beckmann, R. | Deposit date: | 2020-05-28 | Release date: | 2020-07-29 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes. Plos Biol., 18, 2020
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6QW6
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![BU of 6qw6 by Molmil](/molmil-images/mine/6qw6) | Structure of the human U5.U4/U6 tri-snRNP at 2.9A resolution. | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Charenton, C, Wilkinson, M.E, Nagai, K. | Deposit date: | 2019-03-05 | Release date: | 2019-04-17 | Last modified: | 2020-10-07 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | Mechanism of 5' splice site transfer for human spliceosome activation. Science, 364, 2019
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2XWU
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![BU of 2xwu by Molmil](/molmil-images/mine/2xwu) | CRYSTAL STRUCTURE OF IMPORTIN 13 - UBC9 COMPLEX | Descriptor: | IMPORTIN13, SUMO-CONJUGATING ENZYME UBC9 | Authors: | Gruenwald, M, Bono, F. | Deposit date: | 2010-11-05 | Release date: | 2010-12-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of Importin13-Ubc9 Complex: Nuclear Import and Release of a Key Regulator of Sumoylation. Embo J., 30, 2011
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4W5V
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![BU of 4w5v by Molmil](/molmil-images/mine/4w5v) | Crystal structure of Human SUMO E2-conjugating enzyme (Ubc9) in complex with E1-activating enzyme (Uba2) ubiquitin fold domain (Ufd) | Descriptor: | FORMIC ACID, GLYCEROL, POTASSIUM ION, ... | Authors: | Boucher, L.E, Reiter, K.H, Matunis, M.J, Bosch, J. | Deposit date: | 2014-08-19 | Release date: | 2015-09-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of human SUMO complex To Be Published
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7LS1
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![BU of 7ls1 by Molmil](/molmil-images/mine/7ls1) | 80S ribosome from mouse bound to eEF2 (Class II) | Descriptor: | 28S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Loerch, S, Smith, P.R, Kunder, N, Stanowick, A.D, Lou, T.-F, Campbell, Z.T. | Deposit date: | 2021-02-17 | Release date: | 2021-11-03 | Last modified: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance. Nat Commun, 12, 2021
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7LS2
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![BU of 7ls2 by Molmil](/molmil-images/mine/7ls2) | 80S ribosome from mouse bound to eEF2 (Class I) | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | Authors: | Loerch, S, Smith, P.R, Kunder, N, Stanowick, A.D, Lou, T.-F, Campbell, Z.T. | Deposit date: | 2021-02-17 | Release date: | 2021-11-03 | Last modified: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance. Nat Commun, 12, 2021
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6ZHA
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![BU of 6zha by Molmil](/molmil-images/mine/6zha) | Cryo-EM structure of DNA-PK monomer | Descriptor: | DNA, DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-PKcs, X-ray repair cross-complementing protein 5, ... | Authors: | Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. | Deposit date: | 2020-06-21 | Release date: | 2020-10-21 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.91 Å) | Cite: | Dimers of DNA-PK create a stage for DNA double-strand break repair. Nat.Struct.Mol.Biol., 28, 2021
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6JXU
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![BU of 6jxu by Molmil](/molmil-images/mine/6jxu) | SUMO1 bound to SLS4-SIM peptide from ICP0 | Descriptor: | Small ubiquitin-related modifier, viral protein | Authors: | Hembram, D.S.S, Negi, H, Shet, D, Das, R. | Deposit date: | 2019-04-25 | Release date: | 2020-02-05 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The Viral SUMO-Targeted Ubiquitin Ligase ICP0 is Phosphorylated and Activated by Host Kinase Chk2. J.Mol.Biol., 432, 2020
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6JXV
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![BU of 6jxv by Molmil](/molmil-images/mine/6jxv) | SUMO1 bound to phosphorylated SLS4-SIM peptide from ICP0 | Descriptor: | Phosphorylated SLS4-SIM from ubiquitin E3 ligase ICP0, Small ubiquitin-related modifier | Authors: | Hembram, D.S.S, Negi, H, Shet, D, Das, R. | Deposit date: | 2019-04-25 | Release date: | 2020-02-05 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | The Viral SUMO-Targeted Ubiquitin Ligase ICP0 is Phosphorylated and Activated by Host Kinase Chk2. J.Mol.Biol., 432, 2020
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3KYD
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![BU of 3kyd by Molmil](/molmil-images/mine/3kyd) | Human SUMO E1~SUMO1-AMP tetrahedral intermediate mimic | Descriptor: | 1,2-ETHANEDIOL, 5'-{[(3-aminopropyl)sulfonyl]amino}-5'-deoxyadenosine, SUMO-activating enzyme subunit 1, ... | Authors: | Lima, C.D. | Deposit date: | 2009-12-05 | Release date: | 2010-02-16 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Active site remodelling accompanies thioester bond formation in the SUMO E1. Nature, 463, 2010
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3H6O
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![BU of 3h6o by Molmil](/molmil-images/mine/3h6o) | Activator-Bound Structure of Human Pyruvate Kinase M2 | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, 6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one, Pyruvate kinase isozymes M1/M2, ... | Authors: | Hong, B, Dimov, S, Tempel, W, Auld, D, Thomas, C, Boxer, M, Jianq, J.-K, Skoumbourdis, A, Min, S, Southall, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Inglese, J, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2009-04-23 | Release date: | 2009-05-05 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Activator-Bound Structures of Human Pyruvate Kinase M2 to be published
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