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8SQN
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CryoEM structure of Western equine encephalitis virus VLP in complex with the chimeric Du-D1-Mo-D2 MXRA8 receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, DuD1MoD2 chimeric MXRA8, E1 envelope glycoprotein, ...
Authors:Zimmerman, M.I, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:2023-05-04
Release date:2023-12-20
Method:ELECTRON MICROSCOPY (3.89 Å)
Cite:Vertebrate-class-specific binding modes of the alphavirus receptor MXRA8.
Cell, 186, 2023
8SKV
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BU of 8skv by Molmil
Structure of human SIgA1 in complex with Streptococcus pyogenes protein M4 (Arp4)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IgA receptor, ...
Authors:Liu, Q, Stadtmueller, B.M.
Deposit date:2023-04-20
Release date:2023-10-25
Last modified:2023-11-08
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:SIgA structures bound to Streptococcus pyogenes M4 and human CD89 provide insights into host-pathogen interactions.
Nat Commun, 14, 2023
8SKU
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Structure of human SIgA1 in complex with human CD89 (FcaR1)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin J chain, ...
Authors:Liu, Q, Stadtmueller, B.M.
Deposit date:2023-04-20
Release date:2023-10-25
Last modified:2023-11-08
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:SIgA structures bound to Streptococcus pyogenes M4 and human CD89 provide insights into host-pathogen interactions.
Nat Commun, 14, 2023
8J4F
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Structure of human Nav1.7 in complex with Hardwickii acid
Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, (4~{a}~{R},5~{S},6~{R},8~{a}~{R})-5-[2-(furan-3-yl)ethyl]-5,6,8~{a}-trimethyl-3,4,4~{a},6,7,8-hexahydronaphthalene-1-carboxylic acid, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Wu, Q.R, Yan, N.
Deposit date:2023-04-19
Release date:2023-06-14
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural mapping of Na v 1.7 antagonists.
Nat Commun, 14, 2023
8OR1
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BU of 8or1 by Molmil
Co-crystal strucutre of PD-L1 with low molecular weight inhibitor
Descriptor: 5-[[5-[[2-chloranyl-3-(2-fluorophenyl)phenyl]methoxy]-2-[(~{E})-2-hydroxyethyliminomethyl]phenoxy]methyl]pyridine-3-carbonitrile, Programmed cell death 1 ligand 1
Authors:Zhang, H, Zhou, S, Wu, C, Zhu, M, Yu, Q, Wang, X, Awadasseid, A, Plewka, J, Magiera-Mularz, K, Wu, Y, Zhang, W.
Deposit date:2023-04-12
Release date:2023-08-02
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Design, Synthesis, and Antitumor Activity Evaluation of 2-Arylmethoxy-4-(2,2'-dihalogen-substituted biphenyl-3-ylmethoxy) Benzylamine Derivatives as Potent PD-1/PD-L1 Inhibitors.
J.Med.Chem., 66, 2023
8S9C
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BU of 8s9c by Molmil
Cryo-EM structure of Nav1.7 with CBZ
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Fan, X, Huang, J, Yan, N.
Deposit date:2023-03-27
Release date:2023-08-30
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural mapping of Na v 1.7 antagonists.
Nat Commun, 14, 2023
8S9B
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BU of 8s9b by Molmil
Cryo-EM structure of Nav1.7 with LCM
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Fan, X, Huang, J, Yan, N.
Deposit date:2023-03-27
Release date:2023-08-30
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural mapping of Na v 1.7 antagonists.
Nat Commun, 14, 2023
8IIA
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BU of 8iia by Molmil
Crystal structure of the oligomeric state of the extracellular domain of human myelin protein zero(MPZ/P0)
Descriptor: GLYCEROL, Myelin protein P0
Authors:Sakakura, M, Tanabe, M, Mio, K.
Deposit date:2023-02-24
Release date:2023-08-30
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural bases for the Charcot-Marie-Tooth disease induced by single amino acid substitutions of myelin protein zero.
Structure, 31, 2023
8G1A
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BU of 8g1a by Molmil
Cryo-EM structure of Nav1.7 with CBD
Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Fan, X, Huang, J, Yan, N.
Deposit date:2023-02-01
Release date:2023-07-05
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Cannabidiol inhibits Na v channels through two distinct binding sites.
Nat Commun, 14, 2023
8I5Y
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BU of 8i5y by Molmil
Structure of human Nav1.7 in complex with vixotrigine
Descriptor: (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Wu, Q.R, Yan, N.
Deposit date:2023-01-26
Release date:2023-06-14
Last modified:2023-11-08
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural mapping of Na v 1.7 antagonists.
Nat Commun, 14, 2023
8I5X
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BU of 8i5x by Molmil
Structure of human Nav1.7 in complex with Vinpocetine
Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Wu, Q.R, Yan, N.
Deposit date:2023-01-26
Release date:2023-06-14
Last modified:2023-11-08
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural mapping of Na v 1.7 antagonists.
Nat Commun, 14, 2023
8I5G
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BU of 8i5g by Molmil
Structure of human Nav1.7 in complex with PF-05089771
Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Wu, Q.R, Yan, N.
Deposit date:2023-01-25
Release date:2023-06-14
Last modified:2023-11-08
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural mapping of Na v 1.7 antagonists.
Nat Commun, 14, 2023
8I5B
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BU of 8i5b by Molmil
Structure of human Nav1.7 in complex with bupivacaine
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Wu, Q.R, Yan, N.
Deposit date:2023-01-24
Release date:2023-06-14
Last modified:2023-11-08
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural mapping of Na v 1.7 antagonists.
Nat Commun, 14, 2023
8HXS
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BU of 8hxs by Molmil
Small_spotted catshark CD8alpha
Descriptor: T-cell surface glycoprotein CD8 alpha chain
Authors:Wang, J, Zou, J.
Deposit date:2023-01-05
Release date:2023-02-22
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:The first crystal structure of CD8 alpha alpha from a cartilaginous fish.
Front Immunol, 14, 2023
8HXB
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BU of 8hxb by Molmil
Cryo-EM structure of MPXV M2 hexamer in complex with human B7.2
Descriptor: NFkB inhibitor, T-lymphocyte activation antigen CD86
Authors:Wang, Y, Yang, S, Zhao, H, Deng, Z.
Deposit date:2023-01-04
Release date:2023-08-30
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2.
Nat Commun, 14, 2023
8HXA
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BU of 8hxa by Molmil
Cryo-EM structure of MPXV M2 in complex with human B7.1
Descriptor: NFkB inhibitor, T-lymphocyte activation antigen CD80
Authors:Wang, Y, Yang, S, Zhao, H, Deng, Z.
Deposit date:2023-01-04
Release date:2023-08-30
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2.
Nat Commun, 14, 2023
8HXC
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BU of 8hxc by Molmil
Cryo-EM structure of MPXV M2 heptamer in complex with human B7.2
Descriptor: NFkB inhibitor, T-lymphocyte activation antigen CD86
Authors:Wang, Y, Yang, S, Zhao, H, Deng, Z.
Deposit date:2023-01-04
Release date:2023-08-30
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2.
Nat Commun, 14, 2023
8FK5
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BU of 8fk5 by Molmil
Cryo-EM Structure of PG9RSH DU011 Fab in complex with BG505 DS-SOSIP.664
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ...
Authors:Gorman, J, Kwong, P.D.
Deposit date:2022-12-20
Release date:2023-05-31
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Improved HIV-1 neutralization breadth and potency of V2-apex antibodies by in silico design.
Cell Rep, 42, 2023
8FHD
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BU of 8fhd by Molmil
Cryo-EM structure of human voltage-gated sodium channel Nav1.6
Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, (5E,17R,20S)-23-amino-20-hydroxy-14,20-dioxo-15,19,21-trioxa-20lambda~5~-phosphatricos-5-en-17-yl hexadecanoate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Fan, X, Huang, J, Yan, N.
Deposit date:2022-12-14
Release date:2023-02-08
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM structure of human voltage-gated sodium channel Na v 1.6.
Proc.Natl.Acad.Sci.USA, 120, 2023
8HIT
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BU of 8hit by Molmil
Crystal structure of anti-CTLA-4 humanized IgG1 MAb--JS007 in complex with human CTLA-4
Descriptor: Cytotoxic T-lymphocyte protein 4, JS007-VH, JS007-VL
Authors:Tan, S, Shi, Y, Wang, Q, Gao, G.F, Guan, J, Chai, Y, Qi, J.
Deposit date:2022-11-21
Release date:2023-02-01
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Characterization of the high-affinity anti-CTLA-4 monoclonal antibody JS007 for immune checkpoint therapy of cancer.
Mabs, 15, 2023
8BPF
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BU of 8bpf by Molmil
FcMR binding at subunit Fcu1 of IgM pentamer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fas apoptotic inhibitory molecule 3, ...
Authors:Chen, Q, Rosenthal, P, Tolar, P.
Deposit date:2022-11-16
Release date:2023-04-12
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural basis for Fc receptor recognition of immunoglobulin M.
Nat.Struct.Mol.Biol., 30, 2023
8BPE
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BU of 8bpe by Molmil
8:1 binding of FcMR on IgM pentameric core
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fas apoptotic inhibitory molecule 3, ...
Authors:Chen, Q, Rosenthal, P, Tolar, P.
Deposit date:2022-11-16
Release date:2023-04-12
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (3.63 Å)
Cite:Structural basis for Fc receptor recognition of immunoglobulin M.
Nat.Struct.Mol.Biol., 30, 2023
8BPG
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BU of 8bpg by Molmil
FcMR binding at subunit Fcu3 of IgM pentamer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fas apoptotic inhibitory molecule 3, ...
Authors:Chen, Q, Rosenthal, P, Tolar, P.
Deposit date:2022-11-16
Release date:2023-04-12
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for Fc receptor recognition of immunoglobulin M.
Nat.Struct.Mol.Biol., 30, 2023
8HGJ
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BU of 8hgj by Molmil
Toxascaris leonina galectin (Tl-gal) and Human T-cell immunoglobulin mucin-3 (Tim3) complex
Descriptor: Galectin, Hepatitis A virus cellular receptor 2
Authors:Han, C.W, Jang, S.B.
Deposit date:2022-11-14
Release date:2023-11-22
Method:ELECTRON MICROSCOPY (4.82 Å)
Cite:Toxascaris leonina galectin (Tl-gal) and Human T-cell immunoglobulin mucin-3 (Tim3) complex
To Be Published
8EWF
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BU of 8ewf by Molmil
CryoEM structure of Western equine encephalitis virus VLP in complex with the avian MXRA8 receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Chimeric MXRA8 receptor: D1 from Duck MXRA8 and D2 from Mouse MXRA8, E1 envelope protein, ...
Authors:Zimmerman, M.I, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:2022-10-22
Release date:2023-10-25
Method:ELECTRON MICROSCOPY (3.92 Å)
Cite:Alternate domain repeat usage in an alphavirus entry receptor enables host species expansion
To Be Published

221051

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