8G1A

Cryo-EM structure of Nav1.7 with CBD

Summary for 8G1A

• Entry DOI: 10.2210/pdb8g1a/pdb
• EMDB information: 29665
• Descriptor: Sodium channel protein type 9 subunit alpha, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... (11 entities in total)
• Functional Keywords: cryo-em, sodium channel, vgsc, nav1.7, cbd, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 292863.27

Authors

Fan, X.,Huang, J.,Yan, N. (deposition date: 2023-02-01, release date: 2023-07-05)

• Primary citation: Huang, J.,Fan, X.,Jin, X.,Jo, S.,Zhang, H.B.,Fujita, A.,Bean, B.P.,Yan, N.; Cannabidiol inhibits Na v channels through two distinct binding sites.; Nat Commun, 14:3613-3613, 2023; PubMed: 37330538; DOI: 10.1038/s41467-023-39307-6

Experimental method

ELECTRON MICROSCOPY (2.8 Å)