8G1A

Cryo-EM structure of Nav1.7 with CBD

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Sodium channel protein type 9 subunit alpha	polymer	1988	226620.0	1	UniProt (Q15858) Pfam (PF00520) Pfam (PF11933) Pfam (PF06512) Pfam (PF08016) In PDB	Homo sapiens (human)	Neuroendocrine sodium channel,hNE-Na,Peripheral sodium channel 1,PN1,Sodium channel protein type IX subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.7
2	B	Sodium channel subunit beta-1	polymer	218	24732.1	1	UniProt (Q07699) Pfam (PF07686) In PDB	Homo sapiens (human)
3	C	Sodium channel subunit beta-2	polymer	215	24355.9	1	UniProt (O60939) Pfam (PF07686) In PDB	Homo sapiens (human)
4	D, E	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
5	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
6	A	cannabidiol	non-polymer		314.5	2	Chemie (P0T)
7	A	O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine	non-polymer		792.1	2	Chemie (P5S)
8	A	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	5	Chemie (Y01)
9	A	(3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en	non-polymer		544.8	1	Chemie (9Z9)
10	A, B	1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		510.7	13	Chemie (LPE)
11	A	1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		787.1	4	Chemie (PCW)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	275708.0
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	33
	Total formula weight	16306.4
All*	Total formula weight	292863.3

*Water molecules are not included.