3E1R
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![BU of 3e1r by Molmil](/molmil-images/mine/3e1r) | Midbody targeting of the ESCRT machinery by a non-canonical coiled-coil in CEP55 | Descriptor: | Centrosomal protein of 55 kDa, Programmed cell death 6-interacting protein | Authors: | Lee, H.H, Elia, N, Ghirlando, R, Lippincott-Schwartz, J, Hurley, J.H. | Deposit date: | 2008-08-04 | Release date: | 2008-11-04 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55. Science, 322, 2008
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7W6T
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![BU of 7w6t by Molmil](/molmil-images/mine/7w6t) | CryoEM structure of human KChIP1-Kv4.3-DPP6 complex | Descriptor: | Dipeptidyl aminopeptidase-like protein 6, Isoform 2 of Potassium voltage-gated channel subfamily D member 3, Kv channel-interacting protein 1 | Authors: | Ma, D.M, Guo, J.T. | Deposit date: | 2021-12-02 | Release date: | 2022-11-02 | Method: | ELECTRON MICROSCOPY (3.85 Å) | Cite: | Structural basis for the gating modulation of Kv4.3 by auxiliary subunits. Cell Res., 32, 2022
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7W6S
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![BU of 7w6s by Molmil](/molmil-images/mine/7w6s) | CryoEM structure of human KChIP2-Kv4.3 complex | Descriptor: | Isoform 2 of Potassium voltage-gated channel subfamily D member 3, Kv channel-interacting protein 2 | Authors: | Ma, D.M, Guo, J.T. | Deposit date: | 2021-12-02 | Release date: | 2022-11-02 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis for the gating modulation of Kv4.3 by auxiliary subunits. Cell Res., 32, 2022
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7W6N
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![BU of 7w6n by Molmil](/molmil-images/mine/7w6n) | CryoEM structure of human KChIP1-Kv4.3 complex | Descriptor: | Isoform 2 of Potassium voltage-gated channel subfamily D member 3, Kv channel-interacting protein 1 | Authors: | Ma, D.M, Guo, J.T. | Deposit date: | 2021-12-02 | Release date: | 2022-11-02 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis for the gating modulation of Kv4.3 by auxiliary subunits. Cell Res., 32, 2022
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7CC7
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![BU of 7cc7 by Molmil](/molmil-images/mine/7cc7) | |
4S14
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![BU of 4s14 by Molmil](/molmil-images/mine/4s14) | Crystal structure of the orphan nuclear receptor RORgamma ligand-binding domain in complex with 4alpha-caboxyl, 4beta-methyl-zymosterol (4ACD8) | Descriptor: | (3beta,4alpha,5beta,14beta)-3-hydroxy-4-methylcholesta-8,24-diene-4-carboxylic acid, Nuclear receptor ROR-gamma, Nuclear receptor-interacting protein 1 | Authors: | Huang, P, Santori, F.R, Littman, D.R, Rastinejad, F. | Deposit date: | 2015-01-07 | Release date: | 2015-02-11 | Last modified: | 2015-02-25 | Method: | X-RAY DIFFRACTION (3.542 Å) | Cite: | Identification of Natural ROR gamma Ligands that Regulate the Development of Lymphoid Cells. Cell Metab, 21, 2015
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4PXJ
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![BU of 4pxj by Molmil](/molmil-images/mine/4pxj) | |
5HOE
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![BU of 5hoe by Molmil](/molmil-images/mine/5hoe) | Crystal structrue of Est24, a carbohydrate acetylesterase from Sinorhizobium meliloti | Descriptor: | HEXAETHYLENE GLYCOL, Hydrolase, PHOSPHATE ION | Authors: | Oh, C, Ryu, B.H, An, D.R, Nguyen, D.D, Yoo, W, Kim, T, Ngo, D.T, Kim, H.S, Park, J.S, Kim, K.K, Kim, T.D. | Deposit date: | 2016-01-19 | Release date: | 2016-04-27 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structural and Biochemical Characterization of an Octameric Carbohydrate Acetylesterase from Sinorhizobium meliloti. Febs Lett., 590, 2016
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2R02
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![BU of 2r02 by Molmil](/molmil-images/mine/2r02) | |
5E98
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![BU of 5e98 by Molmil](/molmil-images/mine/5e98) | |
5E9B
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![BU of 5e9b by Molmil](/molmil-images/mine/5e9b) | Crystal structure of human heparanase in complex with HepMer M09S05a | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid, CHLORIDE ION, ... | Authors: | Wu, L, Davies, G.J. | Deposit date: | 2015-10-14 | Release date: | 2015-11-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Structural characterization of human heparanase reveals insights into substrate recognition. Nat.Struct.Mol.Biol., 22, 2015
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4XVX
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![BU of 4xvx by Molmil](/molmil-images/mine/4xvx) | Crystal structure of an acyl-ACP dehydrogenase | Descriptor: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, Acyl-[acyl-carrier-protein] dehydrogenase MbtN, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ... | Authors: | Chai, A, Johnston, J.M, Bunker, R.D, Lott, J.S, Baker, E.N, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2015-01-28 | Release date: | 2015-02-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A covalent adduct of MbtN, an acyl-ACP dehydrogenase from Mycobacterium tuberculosis, reveals an unusual acyl-binding pocket. Acta Crystallogr.,Sect.D, 71, 2015
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2H96
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![BU of 2h96 by Molmil](/molmil-images/mine/2h96) | Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun NH2-terminal Kinase Inhibitors | Descriptor: | 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE, C-jun-amino-terminal kinase-interacting protein 1, GLYCEROL, ... | Authors: | Abad-Zapatero, C. | Deposit date: | 2006-06-09 | Release date: | 2006-07-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors. J.Med.Chem., 49, 2006
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4C8B
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![BU of 4c8b by Molmil](/molmil-images/mine/4c8b) | Structure of the kinase domain of human RIPK2 in complex with ponatinib | Descriptor: | 1,2-ETHANEDIOL, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2 | Authors: | Canning, P, Krojer, T, Bradley, A, Mahajan, P, Goubin, S, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A. | Deposit date: | 2013-09-30 | Release date: | 2013-10-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors. Chem. Biol., 22, 2015
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8H3W
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2MWN
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![BU of 2mwn by Molmil](/molmil-images/mine/2mwn) | Talin-F3 / RIAM N-terminal Peptide complex | Descriptor: | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein, Talin-1 | Authors: | Yang, J, Zhu, L, Zhang, H, Hirbawi, J, Fukuda, K, Dwivedi, P, Liu, J, Byzova, T, Plow, E.F, Wu, J, Qin, J. | Deposit date: | 2014-11-13 | Release date: | 2014-12-17 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion. Nat Commun, 5, 2014
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7Q8A
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![BU of 7q8a by Molmil](/molmil-images/mine/7q8a) | Crystal structure of tandem domain RRM1-2 of FUBP-interacting repressor (FIR) bound to FUSE ssDNA fragment | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(P*GP*T)-3'), Poly(U)-binding-splicing factor PUF60, ... | Authors: | Ni, X, Joerger, A.C, Chaikuad, A, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2021-11-10 | Release date: | 2022-11-09 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal structure of tandem domain RRM1-2 of FIR bound to FUSE ssDNA fragment To Be Published
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4D6K
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![BU of 4d6k by Molmil](/molmil-images/mine/4d6k) | Structure of DNTTIP1 dimerisation domain. | Descriptor: | DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1 | Authors: | Itoh, T, Fairall, L, Schwabe, J.W.R. | Deposit date: | 2014-11-11 | Release date: | 2015-02-18 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural and Functional Characterization of a Cell Cycle Associated Hdac1/2 Complex Reveals the Structural Basis for Complex Assembly and Nucleosome Targeting. Nucleic Acids Res., 43, 2015
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4R8P
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![BU of 4r8p by Molmil](/molmil-images/mine/4r8p) | Crystal structure of the Ring1B/Bmi1/UbcH5c PRC1 ubiquitylation module bound to the nucleosome core particle | Descriptor: | DNA (147-mer), E3 ubiquitin-protein ligase RING2, Ubiquitin-conjugating enzyme E2 D3, ... | Authors: | McGinty, R.K, Henrici, R.C, Tan, S. | Deposit date: | 2014-09-02 | Release date: | 2014-11-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.2846 Å) | Cite: | Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome. Nature, 514, 2014
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2OEW
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![BU of 2oew by Molmil](/molmil-images/mine/2oew) | Structure of ALIX/AIP1 Bro1 Domain | Descriptor: | Programmed cell death 6-interacting protein | Authors: | Fisher, R.D, Zhai, Q, Robinson, H, Hill, C.P. | Deposit date: | 2007-01-01 | Release date: | 2007-03-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structural and Biochemical Studies of ALIX/AIP1 and Its Role in Retrovirus Budding Cell(Cambridge,Mass.), 128, 2007
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2OJQ
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![BU of 2ojq by Molmil](/molmil-images/mine/2ojq) | Crystal structure of Alix V domain | Descriptor: | Programmed cell death 6-interacting protein | Authors: | Lee, S, Hurley, J.H. | Deposit date: | 2007-01-13 | Release date: | 2007-02-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.87 Å) | Cite: | Structural basis for viral late-domain binding to Alix Nat.Struct.Mol.Biol., 14, 2007
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2OEX
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![BU of 2oex by Molmil](/molmil-images/mine/2oex) | Structure of ALIX/AIP1 V Domain | Descriptor: | Programmed cell death 6-interacting protein | Authors: | Fisher, R.D, Zhai, Q, Robinson, H, Hill, C.P. | Deposit date: | 2007-01-01 | Release date: | 2007-03-27 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Structural and Biochemical Studies of ALIX/AIP1 and Its Role in Retrovirus Budding Cell(Cambridge,Mass.), 128, 2007
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2OEV
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![BU of 2oev by Molmil](/molmil-images/mine/2oev) | Crystal structure of ALIX/AIP1 | Descriptor: | Programmed cell death 6-interacting protein | Authors: | Fisher, R.D, Zhai, Q, Robinson, H, Hill, C.P. | Deposit date: | 2007-01-01 | Release date: | 2007-03-27 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural and Biochemical Studies of ALIX/AIP1 and Its Role in Retrovirus Budding Cell(Cambridge,Mass.), 128, 2007
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5LA7
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![BU of 5la7 by Molmil](/molmil-images/mine/5la7) | Crystal structure of human proheparanase, in complex with glucuronic acid configured aziridine probe JJB355 | Descriptor: | (1~{S},2~{R},3~{S},4~{S},5~{S},6~{R})-2-(8-azidooctylamino)-3,4,5,6-tetrakis(oxidanyl)cyclohexane-1-carboxylic acid, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wu, L, Jin, Y, Davies, G.J. | Deposit date: | 2016-06-13 | Release date: | 2017-05-31 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Activity-based probes for functional interrogation of retaining beta-glucuronidases. Nat. Chem. Biol., 13, 2017
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4E73
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![BU of 4e73 by Molmil](/molmil-images/mine/4e73) | Crystal structure of JNK1beta-JIP in complex with an azaquinolone inhbitor | Descriptor: | C-Jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 8, methyl 3-(4-{[(1R,2S,3S,5S,7s)-5-aminotricyclo[3.3.1.1~3,7~]dec-2-yl]carbamoyl}benzyl)-4-oxo-1-phenyl-1,4-dihydro-1,8-naphthyridine-2-carboxylate | Authors: | Lukacs, C.M, Janson, C.A. | Deposit date: | 2012-03-16 | Release date: | 2013-05-29 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Identification of an Adamantyl Azaquinolone JNK Selective Inhibitor. ACS Med Chem Lett, 3, 2012
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