5LA7

Crystal structure of human proheparanase, in complex with glucuronic acid configured aziridine probe JJB355

Summary for 5LA7

Entry DOI	10.2210/pdb5la7/pdb
Descriptor	Heparanase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	hydrolase, heparanase, proenzyme, gh79
Biological source	Homo sapiens (Human)
Cellular location	Lysosome membrane; Peripheral membrane protein: Q9Y251
Total number of polymer chains	1
Total formula weight	59692.09
Authors	Wu, L.,Jin, Y.,Davies, G.J. (deposition date: 2016-06-13, release date: 2017-05-31, Last modification date: 2024-01-10)
Primary citation	Wu, L.,Jiang, J.,Jin, Y.,Kallemeijn, W.W.,Kuo, C.L.,Artola, M.,Dai, W.,van Elk, C.,van Eijk, M.,van der Marel, G.A.,Codee, J.D.C.,Florea, B.I.,Aerts, J.M.F.G.,Overkleeft, H.S.,Davies, G.J. Activity-based probes for functional interrogation of retaining beta-glucuronidases. Nat. Chem. Biol., 13:867-873, 2017 Cited by PubMed: 28581485 DOI: 10.1038/nchembio.2395 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94 Å)

Structure validation