5LA7
Crystal structure of human proheparanase, in complex with glucuronic acid configured aziridine probe JJB355
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Heparanase | polymer | 509 | 57725.1 | 1 | UniProt (Q9Y251) Pfam (PF03662) | Homo sapiens (Human) | Endo-glucoronidase,Heparanase-1,Hpa1 |
| 2 | B (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 3 | C, D, E (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 4 | F, G, H, I, J... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 5 | L (A) | (1~{S},2~{R},3~{S},4~{S},5~{S},6~{R})-2-(8-azidooctylamino)-3,4,5,6-tetrakis(oxidanyl)cyclohexane-1-carboxylic acid | non-polymer | 360.4 | 1 | Chemie (6S6) | |||
| 6 | M (A) | water | water | 18.0 | 154 | Chemie (HOH) |
Sequence modifications
A: 36 - 543 (UniProt: Q9Y251)
| PDB | External Database | Details |
|---|---|---|
| Gly 35 | - | expression tag |
| Arg 307 | Lys 307 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 57725.1 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 570.5 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1396.4 | |
| All* | Total formula weight | 59692.1 |
