4E73

Crystal structure of JNK1beta-JIP in complex with an azaquinolone inhbitor

Summary for 4E73

Entry DOI	10.2210/pdb4e73/pdb
Related	1UKH
Descriptor	Mitogen-activated protein kinase 8, C-Jun-amino-terminal kinase-interacting protein 1, methyl 3-(4-{[(1R,2S,3S,5S,7s)-5-aminotricyclo[3.3.1.1~3,7~]dec-2-yl]carbamoyl}benzyl)-4-oxo-1-phenyl-1,4-dihydro-1,8-naphthyridine-2-carboxylate, ... (4 entities in total)
Functional Keywords	kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: P45983 Cytoplasm (By similarity): Q9UQF2
Total number of polymer chains	2
Total formula weight	44468.45
Authors	Lukacs, C.M.,Janson, C.A. (deposition date: 2012-03-16, release date: 2013-05-29, Last modification date: 2023-09-13)
Primary citation	Haynes, N.E.,Scott, N.R.,Chen, L.C.,Janson, C.A.,Li, J.K.,Lukacs, C.M.,Railkar, A.,Tozzo, E.,Whittard, T.,Brown, N.F.,Cheung, A.W. Identification of an Adamantyl Azaquinolone JNK Selective Inhibitor. ACS Med Chem Lett, 3:764-768, 2012 Cited by PubMed: 24900545 DOI: 10.1021/ml300175c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.27 Å)

Structure validation