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4E73

Crystal structure of JNK1beta-JIP in complex with an azaquinolone inhbitor

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AMitogen-activated protein kinase 8polymer36942588.21UniProt (P45983)
Pfam (PF00069)
In PDB
Homo sapiens (human)MAP kinase 8, MAPK 8, JNK-46, Stress-activated protein kinase 1c, SAPK1c, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1
2BC-Jun-amino-terminal kinase-interacting protein 1polymer111317.61UniProt (Q9UQF2)
In PDB
Homo sapiensJIP-1, JNK-interacting protein 1, Islet-brain 1, IB-1, JNK MAP kinase scaffold protein 1, Mitogen-activated protein kinase 8-interacting protein 1
3Amethyl 3-(4-{[(1R,2S,3S,5S,7s)-5-aminotricyclo[3.3.1.1~3,7~]dec-2-yl]carbamoyl}benzyl)-4-oxo-1-phenyl-1,4-dihydro-1,8-naphthyridine-2-carboxylatenon-polymer562.71Chemie (0NR)
4waterwater18.089Chemie (HOH)
Sequence modifications
A: 1 - 363 (UniProt: P45983)
PDBExternal DatabaseDetails
His 364-expression tag
His 365-expression tag
His 366-expression tag
His 367-expression tag
His 368-expression tag
His 369-expression tag
B: 153 - 163 (UniProt: Q9UQF2)
PDBExternal DatabaseDetails
Lys 153Arg 157conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight43905.8
Non-Polymers*Number of molecules1
Total formula weight562.7
All*Total formula weight44468.4
*Water molecules are not included.

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PDB entries from 2024-07-17

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