4E73
Crystal structure of JNK1beta-JIP in complex with an azaquinolone inhbitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Mitogen-activated protein kinase 8 | polymer | 369 | 42588.2 | 1 | UniProt (P45983) Pfam (PF00069) In PDB | Homo sapiens (human) | MAP kinase 8, MAPK 8, JNK-46, Stress-activated protein kinase 1c, SAPK1c, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1 |
2 | B | C-Jun-amino-terminal kinase-interacting protein 1 | polymer | 11 | 1317.6 | 1 | UniProt (Q9UQF2) In PDB | Homo sapiens | JIP-1, JNK-interacting protein 1, Islet-brain 1, IB-1, JNK MAP kinase scaffold protein 1, Mitogen-activated protein kinase 8-interacting protein 1 |
3 | A | methyl 3-(4-{[(1R,2S,3S,5S,7s)-5-aminotricyclo[3.3.1.1~3,7~]dec-2-yl]carbamoyl}benzyl)-4-oxo-1-phenyl-1,4-dihydro-1,8-naphthyridine-2-carboxylate | non-polymer | 562.7 | 1 | Chemie (0NR) | |||
4 | water | water | 18.0 | 89 | Chemie (HOH) |
Sequence modifications
A: 1 - 363 (UniProt: P45983)
B: 153 - 163 (UniProt: Q9UQF2)
PDB | External Database | Details |
---|---|---|
His 364 | - | expression tag |
His 365 | - | expression tag |
His 366 | - | expression tag |
His 367 | - | expression tag |
His 368 | - | expression tag |
His 369 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Lys 153 | Arg 157 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 43905.8 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 562.7 | |
All* | Total formula weight | 44468.4 |