1UKH

Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125

Summary for 1UKH

• Entry DOI: 10.2210/pdb1ukh/pdb
• Related: 1UKI
• Descriptor: Mitogen-activated protein kinase 8 isoform 4, 11-mer peptide from C-jun-amino-terminal kinase interacting protein 1 (3 entities in total)
• Functional Keywords: transferase, phosphorylation
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm (By similarity): Q9WVI9
• Total number of polymer chains: 2
• Total formula weight: 43933.80

Authors

Heo, Y.-S.,Kim, Y.K.,Sung, B.-J.,Lee, H.S.,Lee, J.I.,Seo, C.I.,Park, S.-Y.,Kim, J.H.,Hyun, Y.-L.,Jeon, Y.H.,Ro, S.,Lee, T.G.,Cho, J.M.,Hwang, K.Y.,Yang, C.-H. (deposition date: 2003-08-23, release date: 2004-08-30, Last modification date: 2023-12-27)

• Primary citation: Heo, Y.-S.,Kim, S.K.,Seo, C.I.,Kim, Y.K.,Sung, B.-J.,Lee, H.S.,Lee, J.I.,Park, S.-Y.,Kim, J.H.,Hwang, K.Y.,Hyun, Y.-L.,Jeon, Y.H.,Ro, S.,Cho, J.M.,Lee, T.G.,Yang, C.-H.; Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125; Embo J., 23:2185-2195, 2004; PubMed: 15141161; DOI: 10.1038/sj.emboj.7600212

Experimental method

X-RAY DIFFRACTION (2.35 Å)