2MWN

Talin-F3 / RIAM N-terminal Peptide complex

Summary for 2MWN

DescriptorAmyloid beta A4 precursor protein-binding family B member 1-interacting protein, Talin-1 (2 entities in total)
Functional Keywordsriam, talin, integrin, structural protein-signaling protein complex, structural protein/signaling protein
Biological sourceHomo sapiens (human)
Cellular locationCell membrane ; Peripheral membrane protein  Q7Z5R6
Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side  Q9Y490
Total number of polymer chains2
Total molecular weight13339.3
Authors
Yang, J.,Zhu, L.,Zhang, H.,Hirbawi, J.,Fukuda, K.,Dwivedi, P.,Liu, J.,Byzova, T.,Plow, E.F.,Wu, J.,Qin, J. (deposition date: 2014-11-13, release date: 2014-12-17, Last modification date: 2015-01-14)
Primary citation
Yang, J.,Zhu, L.,Zhang, H.,Hirbawi, J.,Fukuda, K.,Dwivedi, P.,Liu, J.,Byzova, T.,Plow, E.F.,Wu, J.,Qin, J.
Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion.
Nat Commun, 5:5880-5880, 2014
PubMed: 25520155 (PDB entries with the same primary citation)
DOI: 10.1038/ncomms6880
MImport into Mendeley
Experimental method
SOLUTION NMR
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers51 4.5% 27.2%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation reportDownload
171916
PDB entries from 2020-12-02