PDB: 2407 resultsInfo pagesStatus searchChemie searchBIRD

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3MKS	Crystal Structure of yeast Cdc4/Skp1 in complex with an allosteric inhibitor SCF-I2 Descriptor: 1,1'-binaphthalene-2,2'-dicarboxylic acid, Cell division control protein 4, GLYCEROL, ... Authors: Orlicky, S, Sicheri, F, Tyers, M, Tang, X. Deposit date: 2010-04-15 Release date: 2010-07-21 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.6 Å) Cite: An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase. Nat.Biotechnol., 28, 2010
3MKQ	Crystal structure of yeast alpha/betaprime-COP subcomplex of the COPI vesicular coat Descriptor: Coatomer beta'-subunit, Coatomer subunit alpha Authors: Lee, C, Goldberg, J. Deposit date: 2010-04-15 Release date: 2010-07-14 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of coatomer cage proteins and the relationship among COPI, COPII, and clathrin vesicle coats. Cell(Cambridge,Mass.), 142, 2010
3MZK	Sec13/Sec16 complex, S.cerevisiae Descriptor: Protein transport protein SEC13, Protein transport protein SEC16 Authors: Whittle, J.R, Schwartz, T.U. Deposit date: 2010-05-12 Release date: 2010-08-18 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Structure of the Sec13-Sec16 edge element, a template for assembly of the COPII vesicle coat. J.Cell Biol., 190, 2010
5VLJ	Cryo-EM structure of yeast cytoplasmic dynein with Walker B mutation at AAA3 in presence of ATP-VO4 Descriptor: Dynein heavy chain, cytoplasmic, Nuclear distribution protein PAC1 Authors: Cianfrocco, M.A, DeSantis, M.E, Htet, Z.M, Tran, P.T, Reck-Peterson, S.L, Leschziner, A.E. Deposit date: 2017-04-25 Release date: 2017-09-06 Last modified: 2020-01-01 Method: ELECTRON MICROSCOPY (10.5 Å) Cite: Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein. Cell, 170, 2017
5VTB	Crystal structure of RBBP4 bound to BCL11a peptide Descriptor: B-cell lymphoma/leukemia 11A, GLYCEROL, Histone-binding protein RBBP4 Authors: Meagher, J.L, Stuckey, J.A. Deposit date: 2017-05-16 Release date: 2017-12-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epigenetic complexes. J. Biol. Chem., 293, 2018
5VK3	Apo ctPRC2 with E840A and K852D mutations in Ezh2 Descriptor: Histone-lysine N-methyltransferase EZH2,Polycomb protein SUZ12, Polycomb Protein EED, ZINC ION Authors: Bratkowski, M.A, Liu, X. Deposit date: 2017-04-20 Release date: 2017-06-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.114 Å) Cite: Polycomb repressive complex 2 in an autoinhibited state. J. Biol. Chem., 292, 2017
5WAK	Crystal Structure of a Suz12-Rbbp4 Binary Complex Descriptor: Histone-binding protein RBBP4, Polycomb protein SUZ12, ZINC ION Authors: Chen, S, Jiao, L, Liu, X. Deposit date: 2017-06-26 Release date: 2018-03-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding. Mol. Cell, 69, 2018
5WBL	Crystal structure of the Arabidopsis thaliana Raptor in complex with the TOS peptide of human PRAS40 Descriptor: Proline-rich AKT1 substrate 1, Regulatory-associated protein of TOR 1 Authors: Pavletich, N.P, Jiang, X. Deposit date: 2017-06-29 Release date: 2017-12-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.35 Å) Cite: Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBK	Crystal structure of the arabidopsis thaliana Raptor in complex with the TOS peptide of human S6K1 Descriptor: Regulatory-associated protein of TOR 1, Ribosomal protein S6 kinase beta-1 Authors: Pavletich, N.P, Jiang, X. Deposit date: 2017-06-29 Release date: 2017-12-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.11 Å) Cite: Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WUK	Crystal structure of EED [G255D] in complex with EZH2 peptide and EED226 compound Descriptor: GLYCEROL, Histone-lysine N-methyltransferase EZH2, N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... Authors: Chen, Z. Deposit date: 2016-12-19 Release date: 2017-05-03 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Split luciferase-based biosensors for characterizing EED binders Anal. Biochem., 522, 2017
5WJC	Crystal structure of Schizosaccharomyces pombe Mis16 in complex with Eic1 Descriptor: Eic1 protein, Kinetochore protein Mis16 Authors: An, S, Cho, U.-S, Koldewey, P, Chik, J, Subramanian, L. Deposit date: 2017-07-21 Release date: 2018-06-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.298 Å) Cite: Mis16 Switches Function from a Histone H4 Chaperone to a CENP-ACnp1-Specific Assembly Factor through Eic1 Interaction. Structure, 26, 2018
5WFC	Humanized mutant of the Chaetomium thermophilum Polycomb Repressive Complex 2 bound to the inhibitor GSK343 Descriptor: Histone H3.1, Histone-lysine-N-methyltransferase EZH2, Polycomb protein SUZ12 chimera, ... Authors: Bratkowski, M.A, Liu, X. Deposit date: 2017-07-11 Release date: 2018-06-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.282 Å) Cite: An Evolutionarily Conserved Structural Platform for PRC2 Inhibition by a Class of Ezh2 Inhibitors. Sci Rep, 8, 2018
5WAI	Crystal Structure of a Suz12-Rbbp4-Jarid2-Aebp2 Heterotetrameric Complex Descriptor: Histone-binding protein RBBP4, Jumonji, AT-rich interactive domain 2, ... Authors: Chen, S, Jiao, L, Liu, X. Deposit date: 2017-06-26 Release date: 2018-03-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding. Mol. Cell, 69, 2018
5WBI	Crystal structure of the Arabidopsis thaliana Raptor Descriptor: Regulatory-associated protein of TOR 1 Authors: Pavletich, N.P, Jiang, X. Deposit date: 2017-06-29 Release date: 2017-12-20 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WFD	Humanized mutant of the Chaetomium thermophilum Polycomb Repressive Complex 2 bound to the inhibitor GSK126 Descriptor: 1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-indole-4-carboxamide, Histone-lysine-N-methyltransferase EZH2, Polycomb protein SUZ12 chimera, ... Authors: Bratkowski, M.A, Liu, X. Deposit date: 2017-07-11 Release date: 2018-06-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.654 Å) Cite: An Evolutionarily Conserved Structural Platform for PRC2 Inhibition by a Class of Ezh2 Inhibitors. Sci Rep, 8, 2018
5WF7	Chaetomium thermophilum Polycomb Repressive Complex 2 bound to GSK126 Descriptor: 1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-indole-4-carboxamide, Histone-lysine-N-methyltransferase EZH2, Polycomb protein SUZ12 chimera, ... Authors: Bratkowski, M.A, Liu, X. Deposit date: 2017-07-11 Release date: 2018-06-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.5 Å) Cite: An Evolutionarily Conserved Structural Platform for PRC2 Inhibition by a Class of Ezh2 Inhibitors. Sci Rep, 8, 2018
5WG6	Human Polycomb Repressive Complex 2 in complex with GSK126 inhibitor Descriptor: 1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-indole-4-carboxamide, Histone-lysine N-methyltransferase EZH2,Polycomb protein SUZ12 (E.C.2.1.1.43) chimera, Polycomb protein EED, ... Authors: Bratkowski, M.A, Liu, X. Deposit date: 2017-07-13 Release date: 2018-06-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.901 Å) Cite: An Evolutionarily Conserved Structural Platform for PRC2 Inhibition by a Class of Ezh2 Inhibitors. Sci Rep, 8, 2018
5WBU	Crystal structure of mTOR(deltaN)-mLST8-PRAS40(alpha-helix & beta-strand) complex Descriptor: Proline-rich AKT1 substrate 1, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 Authors: Pavletich, N.P, Yang, H. Deposit date: 2017-06-29 Release date: 2017-12-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.42 Å) Cite: Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBJ	Crystal structure of the arabidopsis thaliana Raptor in complex with the TOS peptide of human 4EBP1 Descriptor: Eukaryotic translation initiation factor 4E-binding protein 1, Regulatory-associated protein of TOR 1 Authors: Pavletich, N.P, Jiang, X. Deposit date: 2017-06-29 Release date: 2017-12-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3 Å) Cite: Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBY	Crystal structure of mTOR(deltaN)-mLST8-PRAS40(beta-strand) complex Descriptor: Proline-rich AKT1 substrate 1, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 Authors: Pavletich, N.P, Yang, H. Deposit date: 2017-06-29 Release date: 2017-12-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5XWR	Crystal Structure of RBBP4-peptide complex Descriptor: Histone-binding protein RBBP4, MET-SER-ARG-ARG-LYS-GLN-ALA-LYS-PRO-GLN-HIS-ILE Authors: Jobichen, C, Lui, B.H, Daniel, G.T, Sivaraman, J. Deposit date: 2017-06-30 Release date: 2018-07-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5XXQ	Crystal structure of RBBP4: ZNF827 and its function in telomere Descriptor: Histone-binding protein RBBP4, Zinc finger protein 827 Authors: Sun, A, Shi, Y. Deposit date: 2017-07-04 Release date: 2018-08-08 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of RBBP4: ZNF827 and its function in telomere To Be Published
5Y1U	Crystal structure of RBBP4 bound to AEBP2 RRK motif Descriptor: Histone-binding protein RBBP4, SULFATE ION, Zinc finger protein AEBP2 Authors: Sun, A, Li, F, Wu, J, Shi, Y. Deposit date: 2017-07-21 Release date: 2018-04-18 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.141 Å) Cite: Structural and biochemical insights into human zinc finger protein AEBP2 reveals interactions with RBBP4 Protein Cell, 2017
5ZCS	4.9 Angstrom Cryo-EM structure of human mTOR complex 2 Descriptor: Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ... Authors: Chen, X, Liu, M, Tian, Y, Wang, H, Wang, J, Xu, Y. Deposit date: 2018-02-20 Release date: 2018-03-21 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (4.9 Å) Cite: Cryo-EM structure of human mTOR complex 2. Cell Res., 28, 2018
5K1A	Crystal structure of the UAF1-USP12 complex in C2 space group Descriptor: Ubiquitin carboxyl-terminal hydrolase 12, WD repeat-containing protein 48, ZINC ION Authors: Li, H, D'Andrea, A.D, Zheng, N. Deposit date: 2016-05-18 Release date: 2016-07-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20. Mol.Cell, 63, 2016

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