4CI8
Crystal structure of the tandem atypical beta-propeller domain of EML1
Summary for 4CI8
| Entry DOI | 10.2210/pdb4ci8/pdb |
| Descriptor | ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 1, SULFATE ION (3 entities in total) |
| Functional Keywords | structural protein, eml1, eml4-alk, hsp90 inhibitors, tubulin-binding, beta propeller |
| Biological source | HOMO SAPIENS (HUMAN) |
| Cellular location | Cytoplasm : O00423 |
| Total number of polymer chains | 2 |
| Total formula weight | 147778.89 |
| Authors | Richards, M.W.,Bayliss, R. (deposition date: 2013-12-06, release date: 2014-04-16, Last modification date: 2017-07-12) |
| Primary citation | Richards, M.W.,Law, E.W.P.,Rennalls, L.P.,Busacca, S.,O'Regan, L.,Fry, A.M.,Fennell, D.A.,Bayliss, R. Crystal Structure of Eml1 Reveals the Basis for Hsp90 Dependence of Oncogenic Eml4-Alk by Disruption of an Atypical Beta-Propeller Domain. Proc.Natl.Acad.Sci.USA, 111:5195-, 2014 Cited by PubMed: 24706829DOI: 10.1073/PNAS.1322892111 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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