8VMF
 
 | | Crystal structure of a transition-state mimic of the GSK-3/Axin complex bound to a beta-catenin S45D peptide | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Axin-1, ... | | Authors: | Enos, M.D, Gavagan, M, Jameson, N, Zalatan, J.G, Weis, W.I. | | Deposit date: | 2024-01-13 | | Release date: | 2024-08-28 | | Last modified: | 2024-09-25 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural and functional effects of phosphopriming and scaffolding in the kinase GSK-3 beta.
Sci.Signal., 17, 2024
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8VME
 | | Crystal structure of the GSK-3/Axin complex bound to a phosphorylated beta-catenin T41A peptide | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Axin-1, Catenin beta-1, ... | | Authors: | Enos, M.D, Gavagan, M, Jameson, N, Zalatan, J.G, Weis, W.I. | | Deposit date: | 2024-01-13 | | Release date: | 2024-08-28 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural and functional effects of phosphopriming and scaffolding in the kinase GSK-3 beta.
Sci.Signal., 17, 2024
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8VPI
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8V57
 | | Complex of murine cathepsin K with bound cystatin C inhibitor | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cathepsin K, ... | | Authors: | Pedersen, L.C, Xu, D. | | Deposit date: | 2023-11-30 | | Release date: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Heparan sulfate selectively inhibits the collagenase activity of cathepsin K.
Matrix Biol., 129, 2024
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8VCO
 | | Crystal structure of rMcL-1 in complex with N-acetyl-D-galactosamine | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Hernandez-Santoyo, A, Loera-Rubalcava, J. | | Deposit date: | 2023-12-14 | | Release date: | 2024-12-18 | | Last modified: | 2025-05-21 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | A mytilectin from Mytilus californianus: Study of its unique galactoside interactions, oligomerization patterns, and antifungal activity.
Int.J.Biol.Macromol., 308, 2025
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8VCS
 | | Crystal structure of the oligomeric rMcL-1 in complex with lactose | | Descriptor: | CALCIUM ION, Galactose-binding lectin, beta-D-galactopyranose, ... | | Authors: | Hernandez-Santoyo, A, Loera-Rubalcava, J. | | Deposit date: | 2023-12-14 | | Release date: | 2024-12-18 | | Last modified: | 2025-05-21 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | A mytilectin from Mytilus californianus: Study of its unique galactoside interactions, oligomerization patterns, and antifungal activity.
Int.J.Biol.Macromol., 308, 2025
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8VOJ
 | | The Cryo-EM structure of LSD1-CoREST-HDAC1 in complex with KBTBD4 enhanced by UM171 and IP6 | | Descriptor: | (1r,4r)-N~1~-[(7P)-2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl]cyclohexane-1,4-diamine, Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, ... | | Authors: | Xie, X, Mao, H, Liau, B, Zheng, N. | | Deposit date: | 2024-01-15 | | Release date: | 2024-12-04 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.77 Å) | | Cite: | UM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors.
Nature, 639, 2025
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6OM6
 | | Structure of trans-translation inhibitor bound to E. coli 70S ribosome with P site tRNA | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Hoffer, E.D, Mehrani, A, Keiler, K.C, Stagg, S.M, Dunham, C.M. | | Deposit date: | 2019-04-18 | | Release date: | 2021-02-10 | | Last modified: | 2025-03-19 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo.
Nat Commun, 12, 2021
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8VTW
 | | Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-128 and protein Y at 2.35A resolution | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1-cyclopropyl-7-(4-{4-[({[(3aR,4R,7R,8S,9S,10R,11R,13R,14E,15S,15aR)-10-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-4-ethyl-11-methoxy-14-(methoxyimino)-3a,7,9,11,13,15-hexamethyl-2,6-dioxododecahydro-2H,4H-[1,3]dioxolo[4,5-c]oxacyclotetradecin-8-yl]oxy}carbonyl)amino]butyl}piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (non-preferred name), 16S Ribosomal RNA, ... | | Authors: | Aleksandrova, E.V, Ma, C.-X, Klepacki, D, Alizadeh, F, Vazquez-Laslop, N, Liang, J.-H, Polikanov, Y.S, Mankin, A.S. | | Deposit date: | 2024-01-27 | | Release date: | 2024-08-07 | | Last modified: | 2025-03-19 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
Nat.Chem.Biol., 20, 2024
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8W9A
 | | CryoEM structure of human PI3K-alpha (P85/P110-H1047R) with QR-7909 binding at an allosteric site | | Descriptor: | 6-chloranyl-3-[[(1R)-1-[2-(1,3-dihydropyrrolo[3,4-c]pyridin-2-yl)-3,6-dimethyl-4-oxidanylidene-quinazolin-8-yl]ethyl]amino]pyridine-2-carboxylic acid, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | Authors: | Huang, X, Ren, X, Zhong, W. | | Deposit date: | 2023-09-05 | | Release date: | 2024-04-17 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Cryo-EM structures reveal two allosteric inhibition modes of PI3K alpha H1047R involving a re-shaping of the activation loop.
Structure, 32, 2024
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8W9D
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7OHR
 | | Nog1-TAP associated immature ribosomal particle population E from S. cerevisiae | | Descriptor: | 25S rRNA, 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ... | | Authors: | Milkereit, P, Poell, G. | | Deposit date: | 2021-05-11 | | Release date: | 2021-11-10 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (4.72 Å) | | Cite: | Analysis of subunit folding contribution of three yeast large ribosomal subunit proteins required for stabilisation and processing of intermediate nuclear rRNA precursors.
Plos One, 16, 2021
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8UNV
 | | CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class K) | | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | | Deposit date: | 2023-10-19 | | Release date: | 2024-03-06 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
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8U7U
 | | Proteasome 20S Core Particle from Beta 3 D205 deletion | | Descriptor: | Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ... | | Authors: | Walsh Jr, R.M, Rawson, S, Velez, B, Blickling, M, Razi, A, Hanna, J. | | Deposit date: | 2023-09-15 | | Release date: | 2024-04-17 | | Last modified: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (2.16 Å) | | Cite: | Mechanism of autocatalytic activation during proteasome assembly.
Nat.Struct.Mol.Biol., 31, 2024
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8UAT
 | | Thermus scotoductus SA-01 Ene-reductase Compound 3b Complex | | Descriptor: | 1-[2-(4-hydroxyphenyl)ethyl]-1,4-dihydropyridine-3-carboxamide, CHLORIDE ION, FLAVIN MONONUCLEOTIDE, ... | | Authors: | Wilson, L.A, Guddat, L.W, Schenk, G, Scott, C. | | Deposit date: | 2023-09-22 | | Release date: | 2024-07-03 | | Method: | X-RAY DIFFRACTION (2.76 Å) | | Cite: | Structural Characterization of Enzymatic Interactions with Functional Nicotinamide Cofactor Biomimetics
Catalysts, 14, 2024
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8UVS
 | | Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin derivative 2694, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.75A resolution | | Descriptor: | (2R,4R,4aS,5aR,6S,7S,8R,9S,9aR,10aS)-2-methyl-6,8-bis(methylamino)-4-({[2-(oxan-4-yl)ethyl]amino}methyl)octahydro-2H-pyrano[2,3-b][1,4]benzodioxine-4,4a,7,9(10aH)-tetrol, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | | Authors: | Killam, B.Y, Phelps, G.A, Lee, R.E, Polikanov, Y.S. | | Deposit date: | 2023-11-03 | | Release date: | 2024-08-07 | | Last modified: | 2025-03-19 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8UM0
 | | The structure of NanH in complex with Neu5,7,9Ac(2,6)-LAcNAc | | Descriptor: | 1,2-ETHANEDIOL, 5-acetamido-7,9-di-O-acetyl-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosonic acid, Sialidase, ... | | Authors: | Medley, B.J, Boraston, A.B. | | Deposit date: | 2023-10-17 | | Release date: | 2024-09-04 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.46 Å) | | Cite: | A "terminal" case of glycan catabolism: Structural and enzymatic characterization of the sialidases of Clostridium perfringens.
J.Biol.Chem., 300, 2024
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8UFY
 | | High Resolution structure of A. viridans Lactate Oxidase | | Descriptor: | 1,2-ETHANEDIOL, FLAVIN MONONUCLEOTIDE, L-lactate oxidase, ... | | Authors: | Lodowski, D.T. | | Deposit date: | 2023-10-05 | | Release date: | 2024-08-14 | | Last modified: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | An engineered lactate oxidase based electrochemical sensor for continuous detection of biomarker lactic acid in human sweat and serum.
Heliyon, 10, 2024
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8UXQ
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8UX6
 | | Structure of Fab201 with a T. parva sporozoite neutralizing B cell epitope of p67 | | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, ... | | Authors: | Singer, A.U, Gopalsamy, A, Fellouse, F.A, Miersch, S, Sidhu, S.S. | | Deposit date: | 2023-11-08 | | Release date: | 2024-10-16 | | Last modified: | 2025-05-28 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Molecular characterization of a synthetic neutralizing antibody targeting p67 of Theileria parva.
Protein Sci., 34, 2025
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8PMR
 | | NADase from Aspergillus fumigatus with mutated calcium binding motif (D219A/E220A) | | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Kallio, J.P, Ferrario, E, Stromland, O, Ziegler, M. | | Deposit date: | 2023-06-29 | | Release date: | 2023-11-15 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Novel Calcium-Binding Motif Stabilizes and Increases the Activity of Aspergillus fumigatus Ecto-NADase.
Biochemistry, 62, 2023
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8UL1
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6WML
 | | Human TLR8 bound to the potent agonist, GS-9688 (Selgantolimod) | | Descriptor: | (2R)-2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methylhexan-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor 8, ... | | Authors: | Appleby, T.C, Perry, J.K, Mish, M, Villasenor, A.G, Mackman, R.L. | | Deposit date: | 2020-04-21 | | Release date: | 2021-02-03 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B.
J.Med.Chem., 63, 2020
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8VOI
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8VOH
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