3J8D
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![BU of 3j8d by Molmil](/molmil-images/mine/3j8d) | Cryoelectron microscopy of dengue-Fab E104 complex at pH 5.5 | Descriptor: | Envelope protein E, antibody E111 Fab fragment, glycoprotein DIII | Authors: | Zhang, X.Z, Sheng, J, Austin, S.K, Hoornweg, T, Smit, J.M, Kuhn, R.J, Diamond, M.S, Rossmann, M.G. | Deposit date: | 2014-10-13 | Release date: | 2014-11-12 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (26 Å) | Cite: | Structure of Acidic pH Dengue Virus Showing the Fusogenic Glycoprotein Trimers. J.Virol., 89, 2015
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7FU1
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7U24
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![BU of 7u24 by Molmil](/molmil-images/mine/7u24) | Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and glibenclamide with Kir6.2-CTD in the up conformation | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ... | Authors: | Shyng, S.L, Sung, M.W, Driggers, C.M. | Deposit date: | 2022-02-23 | Release date: | 2022-08-31 | Last modified: | 2022-09-14 | Method: | ELECTRON MICROSCOPY (3.58 Å) | Cite: | Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022
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7QOI
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![BU of 7qoi by Molmil](/molmil-images/mine/7qoi) | Unique vertex of the phicrAss001 virion | Descriptor: | Auxiliary capsid protein gp36, Cargo protein 1 gp45, Head fiber trimer protein gp21, ... | Authors: | Bayfield, O.W, Shkoporov, A.N, Yutin, N, Khokhlova, E.V, Smith, J.L.R, Hawkins, D.E.D.P, Koonin, E.V, Hill, C, Antson, A.A. | Deposit date: | 2021-12-24 | Release date: | 2023-03-29 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (3.62 Å) | Cite: | Structural atlas of a human gut crassvirus. Nature, 617, 2023
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2NCN
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8QLQ
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![BU of 8qlq by Molmil](/molmil-images/mine/8qlq) | Human MST3 (STK24) kinase in complex with macrocyclic inhibitor JA310 | Descriptor: | 1,2-ETHANEDIOL, Serine/threonine-protein kinase 24, macrocyclic inhibitor | Authors: | Balourdas, D.I, Amrhein, J.A, Hanke, T, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC) | Deposit date: | 2023-09-20 | Release date: | 2023-11-08 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3. J.Med.Chem., 67, 2024
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7U6Y
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7QPV
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![BU of 7qpv by Molmil](/molmil-images/mine/7qpv) | Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate | Descriptor: | 8-methyl-2-[2-(1-methyl-4-phenyl-imidazol-2-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyridine, MAGNESIUM ION, ZINC ION, ... | Authors: | Leonard, P.M, Langgard, M. | Deposit date: | 2022-01-05 | Release date: | 2023-04-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate To Be Published
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7QAR
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![BU of 7qar by Molmil](/molmil-images/mine/7qar) | Serial crystallography structure of cofactor-free urate oxidase in complex with the 5-peroxo derivative of 9-methyl uric acid at room temperature | Descriptor: | (5S)-5-(dioxidanyl)-9-methyl-7H-purine-2,6,8-trione, Uricase | Authors: | Bui, S, Catapano, L, Zielinski, K, Yefanov, O, Murshudov, G.N, Oberthuer, D, Steiner, R.A. | Deposit date: | 2021-11-17 | Release date: | 2023-04-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Rapid and efficient room-temperature serial synchrotron crystallography using the CFEL TapeDrive. Iucrj, 9, 2022
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5LOO
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3J9X
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![BU of 3j9x by Molmil](/molmil-images/mine/3j9x) | A Virus that Infects a Hyperthermophile Encapsidates A-Form DNA | Descriptor: | DNA, coat protein | Authors: | DiMaio, F, Yu, X, Rensen, E, Krupovic, M, Prangishvili, D, Egelman, E. | Deposit date: | 2015-03-21 | Release date: | 2015-06-03 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | A virus that infects a hyperthermophile encapsidates A-form DNA. Science, 348, 2015
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8QQC
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![BU of 8qqc by Molmil](/molmil-images/mine/8qqc) | Crystal structure of Lymantria dispar CPV14 polyhedra single crystal | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Polyhedrin | Authors: | Trincao, J, Warren, A, Crawshaw, A, Sutton, G, Stuart, D, Evans, G. | Deposit date: | 2023-10-04 | Release date: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | VMXm - sub-micron microfocus beamline for macromolecular crystallography at Diamond Light Source To Be Published
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7U7M
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7QPQ
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![BU of 7qpq by Molmil](/molmil-images/mine/7qpq) | Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate | Descriptor: | 2-[(1-methyl-4-phenyl-imidazol-2-yl)methylsulfanyl]-[1,2,4]triazolo[1,5-a]pyridine, MAGNESIUM ION, ZINC ION, ... | Authors: | Leonard, P.M, Langgard, M. | Deposit date: | 2022-01-05 | Release date: | 2023-04-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate To Be Published
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3JAB
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![BU of 3jab by Molmil](/molmil-images/mine/3jab) | Domain organization and conformational plasticity of the G protein effector, PDE6 | Descriptor: | 3-ISOBUTYL-1-METHYLXANTHINE, GafA domain of cone phosphodiesterase 6C, GafB domain of phosphodiesterase 2A, ... | Authors: | Zhang, Z, He, F, Constantine, R, Baker, M.L, Baehr, W, Schmid, M.F, Wensel, T.G, Agosto, M.A. | Deposit date: | 2015-05-26 | Release date: | 2015-06-10 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (11 Å) | Cite: | Domain Organization and Conformational Plasticity of the G Protein Effector, PDE6. J.Biol.Chem., 290, 2015
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3ANT
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![BU of 3ant by Molmil](/molmil-images/mine/3ant) | Human soluble epoxide hydrolase in complex with a synthetic inhibitor | Descriptor: | 4-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-N-[(1S,2R)-2-phenylcyclopropyl]piperidine-1-carboxamide, Epoxide hydrolase 2 | Authors: | Chiyo, N, Ishii, T, Hourai, S, Yanagi, K. | Deposit date: | 2010-09-08 | Release date: | 2011-01-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | A practical use of ligand efficiency indices out of the fragment-based approach: ligand efficiency-guided lead identification of soluble epoxide hydrolase inhibitors J.Med.Chem., 54, 2011
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7TW9
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7QRI
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![BU of 7qri by Molmil](/molmil-images/mine/7qri) | Regulatory domain dimer of tryptophan hydroxylase 2 in complex with L-Phe | Descriptor: | PHENYLALANINE, Tryptophan 5-hydroxylase 2 | Authors: | Vedel, I.M, Prestel, A, Harris, P, Peters, G.H.J, Kragelund, B.B. | Deposit date: | 2022-01-11 | Release date: | 2023-05-03 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Structural characterization of human tryptophan hydroxylase 2 reveals that L-Phe is superior to L-Trp as the regulatory domain ligand. Structure, 31, 2023
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2MWH
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![BU of 2mwh by Molmil](/molmil-images/mine/2mwh) | NMR solution structure of ligand-free OAA | Descriptor: | Anti-HIV lectin OAA | Authors: | Lee, D, Carneiro, M.G, Koharudin, L.M, Griesinger, C, Gronenborn, A.M, Ban, D, Sabo, T, Trigo-Mourino, P, Mazur, A. | Deposit date: | 2014-11-10 | Release date: | 2015-04-22 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Sampling of Glycan-Bound Conformers by the Anti-HIV Lectin Oscillatoria agardhii agglutinin in the Absence of Sugar. Angew.Chem.Int.Ed.Engl., 54, 2015
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3JT8
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![BU of 3jt8 by Molmil](/molmil-images/mine/3jt8) | Structure of neuronal nitric oxide synthase heme domain complexed with N~5~-{3-[(1-methylethyl)sulfanyl]propanimidoyl}-L-ornithine | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, Nitric oxide synthase, ... | Authors: | Li, H, Poulos, T.L. | Deposit date: | 2009-09-11 | Release date: | 2010-01-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency. J.Am.Chem.Soc., 132, 2010
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7QUH
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![BU of 7quh by Molmil](/molmil-images/mine/7quh) | Siglec-8 in complex with therapeutic Fab AK002. | Descriptor: | Sialic acid-binding Ig-like lectin 8, Sialic acid-binding immunoglobulin-type lectin | Authors: | Lenza, M.P, Oyenarte, I, Jimenez Barbero, J, Ereno Orbea, J. | Deposit date: | 2022-01-18 | Release date: | 2023-05-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.867 Å) | Cite: | Structures of the Inhibitory Receptor Siglec-8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody. Jacs Au, 3, 2023
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7QBJ
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![BU of 7qbj by Molmil](/molmil-images/mine/7qbj) | bacterial IMPDH chimera | Descriptor: | Inosine-5'-monophosphate dehydrogenase | Authors: | Labesse, G, Gelin, M, Munier-Lehmann, H, Gedeon, A, Haouz, A. | Deposit date: | 2021-11-19 | Release date: | 2023-05-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMP dehydrogenases. Protein Sci., 32, 2023
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7TW7
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7LA8
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7A7D
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![BU of 7a7d by Molmil](/molmil-images/mine/7a7d) | Cadherin fit into cryo-ET map | Descriptor: | Desmocollin-2, Desmoglein-2 | Authors: | Sikora, M, Ermel, U.H, Seybold, A, Kunz, M, Calloni, G, Reitz, J, Vabulas, R.M, Hummer, G, Frangakis, A.S. | Deposit date: | 2020-08-28 | Release date: | 2020-12-23 | Method: | ELECTRON MICROSCOPY (26 Å) | Cite: | Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography. Proc.Natl.Acad.Sci.USA, 117, 2020
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