7U6Y

Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of glibenclamide and ATP with Kir6.2-CTD in the down conformation

Summary for 7U6Y

Entry DOI	10.2210/pdb7u6y/pdb
Related	7TYS 7TYT 7U1E 7U1Q 7U1S 7U24 7U2X 7U7M 7UAA 7UQR
EMDB information	26308
Descriptor	ATP-sensitive inward rectifier potassium channel 11, ATP-binding cassette sub-family C member 8, ADENOSINE-5'-TRIPHOSPHATE (3 entities in total)
Functional Keywords	katp channel, sur1, kir6.2, glibenclamide, gbc, gbm, sulfonylurea receptor, potassium transport, metabolic sensor, membrane protein
Biological source	Rattus norvegicus (Norway rat) More
Total number of polymer chains	5
Total formula weight	354516.53
Authors	Shyng, S.L.,Sung, M.W.,Driggers, C.M. (deposition date: 2022-03-06, release date: 2022-08-31, Last modification date: 2024-06-12)
Primary citation	Sung, M.W.,Driggers, C.M.,Mostofian, B.,Russo, J.D.,Patton, B.L.,Zuckerman, D.M.,Shyng, S.L. Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434:167789-167789, 2022 Cited by PubMed: 35964676 DOI: 10.1016/j.jmb.2022.167789 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (7.4 Å)

Structure validation