8ETH
 
 | | Ytm1 associated 60S nascent ribosome State 1B | | Descriptor: | 60S ribosomal protein L13, 60S ribosomal protein L14, 60S ribosomal protein L15-A, ... | | Authors: | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | | Deposit date: | 2022-10-17 | | Release date: | 2022-11-30 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Chromatin localization of nucleophosmin organizes ribosome biogenesis.
Mol.Cell, 82, 2022
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8ETI
 | | Fkbp39 associated 60S nascent ribosome State 1 | | Descriptor: | 60S ribosomal protein L13, 60S ribosomal protein L14, 60S ribosomal protein L15-A, ... | | Authors: | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | | Deposit date: | 2022-10-17 | | Release date: | 2022-11-30 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Chromatin localization of nucleophosmin organizes ribosome biogenesis.
Mol.Cell, 82, 2022
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8ETG
 | | Fkbp39 associated 60S nascent ribosome State 3 | | Descriptor: | 60S ribosomal protein L13, 60S ribosomal protein L14, 60S ribosomal protein L15-A, ... | | Authors: | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | | Deposit date: | 2022-10-17 | | Release date: | 2022-11-30 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Chromatin localization of nucleophosmin organizes ribosome biogenesis.
Mol.Cell, 82, 2022
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8BD0
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8BCM
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8ET7
 | | Cryo-EM structure of the organic cation transporter 1 in complex with diphenhydramine | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-[2-(BENZHYDRYLOXY)ETHYL]-N,N-DIMETHYLAMINE, OCT1 | | Authors: | Suo, Y, Wright, N.J, Lee, S.-Y. | | Deposit date: | 2022-10-16 | | Release date: | 2023-05-31 | | Last modified: | 2023-08-02 | | Method: | ELECTRON MICROSCOPY (3.77 Å) | | Cite: | Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2.
Nat.Struct.Mol.Biol., 30, 2023
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8ET8
 | | Cryo-EM structure of the organic cation transporter 1 in complex with verapamil | | Descriptor: | (2S)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, OCT1 | | Authors: | Suo, Y, Wright, N.J, Lee, S.-Y. | | Deposit date: | 2022-10-16 | | Release date: | 2023-05-31 | | Last modified: | 2023-08-02 | | Method: | ELECTRON MICROSCOPY (3.45 Å) | | Cite: | Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2.
Nat.Struct.Mol.Biol., 30, 2023
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8ET9
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8ET6
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8ETD
 | | Crystal Structure of Schizosaccharomyces pombe Rho1 | | Descriptor: | GTP-binding protein rho1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Huang, Q, Xie, J, Seetharaman, J. | | Deposit date: | 2022-10-16 | | Release date: | 2022-12-07 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.78 Å) | | Cite: | Crystal Structure of Schizosaccharomyces pombe Rho1 Reveals Its Evolutionary Relationship with Other Rho GTPases.
Biology (Basel), 11, 2022
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8ESY
 | | D30N mutant HIV protease in complex with benzoxaborolone analog of darunavir | | Descriptor: | CHLORIDE ION, GLYCEROL, Protease, ... | | Authors: | Windsor, I.W, Graham, B.J, Raines, R.T. | | Deposit date: | 2022-10-15 | | Release date: | 2023-02-08 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Inhibition of HIV-1 Protease by a Boronic Acid with High Oxidative Stability.
Acs Med.Chem.Lett., 14, 2023
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8ET0
 | | Crystal Complex of murine Cyclooxygenase-2 with alpaca nanobody F9 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IBUPROFEN, ... | | Authors: | Xu, S, Banerjee, S, Uddin, M.J, Goodman, M.C, Marnett, L.J. | | Deposit date: | 2022-10-15 | | Release date: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Crystal complex of murine cycloxygenase-2 with alpaca nanobody F9
To Be Published
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8ESX
 | | HIV protease in complex with benzoxaborolone analog of darunavir | | Descriptor: | ACETATE ION, CHLORIDE ION, GLYCEROL, ... | | Authors: | Windsor, I.W, Graham, B.J, Raines, R.T. | | Deposit date: | 2022-10-15 | | Release date: | 2023-02-08 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Inhibition of HIV-1 Protease by a Boronic Acid with High Oxidative Stability.
Acs Med.Chem.Lett., 14, 2023
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8H62
 | | Crystal structure of Internalin A from Listeria monocytogenes with human E-cadherin EC12 | | Descriptor: | ACETATE ION, CALCIUM ION, Cadherin-1, ... | | Authors: | Caaveiro, J.M.M, Nagatoish, S, Tsumoto, K. | | Deposit date: | 2022-10-14 | | Release date: | 2023-10-04 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Anti-InlA single-domain antibodies that inhibit the cell invasion of Listeria monocytogenes.
J.Biol.Chem., 299, 2023
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8ESS
 | | Myoglobin variant Mb-cIII complex | | Descriptor: | Myoglobin, SULFATE ION, [2,18-bis(2-carboxyethyl)-7,12-diethenyl-3,8,13,17-tetramethyl-21-(2-oxo-3-phenylpropyl)porphyrin-21-iumato(2-)-kappa~3~N~22~,N~23~,N~24~]iron(2+) | | Authors: | Bacik, J.P, Fasan, R, Ando, N. | | Deposit date: | 2022-10-14 | | Release date: | 2023-12-06 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Mechanistic manifold in a hemoprotein-catalyzed cyclopropanation reaction with diazoketone.
Nat Commun, 14, 2023
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8ESU
 | | Myoglobin variant Mb-imi complex | | Descriptor: | IMIDAZOLE, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Bacik, J.P, Fasan, R, Ando, N. | | Deposit date: | 2022-10-14 | | Release date: | 2023-12-06 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.04 Å) | | Cite: | Mechanistic manifold in a hemoprotein-catalyzed cyclopropanation reaction with diazoketone.
Nat Commun, 14, 2023
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8ESQ
 | | Ytm1 associated nascent 60S ribosome State 2 | | Descriptor: | 25S rRNA (cytosine-C(5))-methyltransferase nop2, 60S ribosomal protein L13, 60S ribosomal protein L14, ... | | Authors: | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | | Deposit date: | 2022-10-14 | | Release date: | 2022-11-30 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Chromatin localization of nucleophosmin organizes ribosome biogenesis.
Mol.Cell, 82, 2022
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8ESR
 | | Ytm1 associated nascent 60S ribosome (-fkbp39) State 2 | | Descriptor: | 25S rRNA (cytosine-C(5))-methyltransferase nop2, 60S ribosomal protein L13, 60S ribosomal protein L14, ... | | Authors: | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | | Deposit date: | 2022-10-14 | | Release date: | 2022-11-30 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Chromatin localization of nucleophosmin organizes ribosome biogenesis.
Mol.Cell, 82, 2022
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8ESC
 | | Structure of the Yeast NuA4 Histone Acetyltransferase Complex | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, Actin-related protein 4, ... | | Authors: | Patel, A.B, Zukin, S.A, Nogales, E. | | Deposit date: | 2022-10-13 | | Release date: | 2022-11-16 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structure and flexibility of the yeast NuA4 histone acetyltransferase complex.
Elife, 11, 2022
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8H59
 | | A fungal MAP kinase in complex with an inhibitor | | Descriptor: | Mitogen-activated protein kinase MPS1, ~{N}-[(2~{S})-3-(1~{H}-indol-3-yl)-1-(methylamino)-1-oxidanylidene-propan-2-yl]-8-[2-methoxy-5-(trifluoromethyloxy)phenyl]-1,6-naphthyridine-2-carboxamide | | Authors: | Kong, Z, Zhang, X, Wang, D, Liu, J. | | Deposit date: | 2022-10-12 | | Release date: | 2023-02-08 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structure-Aided Identification of an Inhibitor Targets Mps1 for the Management of Plant-Pathogenic Fungi.
Mbio, 14, 2023
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8ERN
 | | Cyclin-free CDK2 in complex with Cpd21 | | Descriptor: | Cyclin-dependent kinase 2, GLYCEROL, N,3-dimethyl-4-({7-[(2S)-2-methylpyrrolidine-1-carbonyl]quinazolin-2-yl}amino)benzene-1-sulfonamide | | Authors: | Murray, J.M, Oh, A. | | Deposit date: | 2022-10-12 | | Release date: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | Cyclin-free CDK2 in complex with Cpd21
To Be Published
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8H55
 | | The structure of zebrafish angiotensinogen | | Descriptor: | Angiotensinogen, SULFATE ION | | Authors: | Zhou, A, Wei, H. | | Deposit date: | 2022-10-12 | | Release date: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | BIOLOGICAL IMPLICATIONS OF A 2 ANGSTROMS STRUCTURE OF DIMERIC ANGIOTENSINOGEN
To Be Published
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8BAV
 | | Secretagogin (human) in complex with its target peptide from SNAP-25 | | Descriptor: | ACETATE ION, CALCIUM ION, Green fluorescent protein,Synaptosomal-associated protein 25, ... | | Authors: | Schnell, R, Szodorai, E. | | Deposit date: | 2022-10-12 | | Release date: | 2024-04-03 | | Last modified: | 2024-04-24 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | A hydrophobic groove in secretagogin allows for alternate interactions with SNAP-25 and syntaxin-4 in endocrine tissues.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8H4V
 | | Mincle CRD complex with PGL trisaccharide | | Descriptor: | (2~{R},3~{R},4~{S},5~{S},6~{R})-6-(methoxymethyl)oxane-2,3,4,5-tetrol-(1-4)-6-deoxy-2,3-di-O-methyl-alpha-L-mannopyranose-(1-2)-3-O-methyl-alpha-L-rhamnopyranose, C-type lectin domain family 4 member E, CALCIUM ION | | Authors: | Ishizuka, S, Nagae, M, Yamasaki, S. | | Deposit date: | 2022-10-11 | | Release date: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | PGL-III, a Rare Intermediate of Mycobacterium leprae Phenolic Glycolipid Biosynthesis, Is a Potent Mincle Ligand.
Acs Cent.Sci., 9, 2023
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8ERD
 | | Cyclin-free CDK2 in complex with Cpd17 | | Descriptor: | (2-{[1-(methanesulfonyl)piperidin-4-yl]amino}quinazolin-7-yl)[(2S)-2-methylpyrrolidin-1-yl]methanone, Cyclin-dependent kinase 2 | | Authors: | Murray, J.M, Oh, A. | | Deposit date: | 2022-10-11 | | Release date: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.33 Å) | | Cite: | Cyclin-free CDK2 in complex with Cpd17
To Be Published
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