8ESX

HIV protease in complex with benzoxaborolone analog of darunavir

Summary for 8ESX

• Entry DOI: 10.2210/pdb8esx/pdb
• Descriptor: Protease, GLYCEROL, CHLORIDE ION, ... (7 entities in total)
• Functional Keywords: virus, protease, inhibitor, boron, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 22381.31

Authors

Windsor, I.W.,Graham, B.J.,Raines, R.T. (deposition date: 2022-10-15, release date: 2023-02-08, Last modification date: 2023-10-25)

• Primary citation: Graham, B.J.,Windsor, I.W.,Raines, R.T.; Inhibition of HIV-1 Protease by a Boronic Acid with High Oxidative Stability.; Acs Med.Chem.Lett., 14:171-175, 2023; PubMed: 36793428; DOI: 10.1021/acsmedchemlett.2c00464

Experimental method

X-RAY DIFFRACTION (1.35 Å)