PDB: 35439 resultsInfo pagesStatus searchChemie searchBIRD

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7NYN	Mutant Y526A of SH3 domain of JNK-interacting Protein 1 (JIP1) Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, ... Authors: Perez, L.M, Ielasi, F.S, Palencia, A, Jensen, M.R. Deposit date: 2021-03-23 Release date: 2021-12-22 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.537 Å) Cite: Visualizing protein breathing motions associated with aromatic ring flipping. Nature, 602, 2022
7NYL	Mutant H493A of SH3 domain of JNK-interacting Protein 1 (JIP1) Descriptor: SH3 domain of JNK-interacting Protein 1 (JIP1), TETRAETHYLENE GLYCOL, alpha-D-glucopyranose-(1-1)-alpha-D-glucopyranose Authors: Perez, L.M, Ielasi, F.S, Palencia, A, Jensen, M.R. Deposit date: 2021-03-23 Release date: 2021-12-22 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Visualizing protein breathing motions associated with aromatic ring flipping. Nature, 602, 2022
7NYK	SH3 domain of JNK-interacting Protein 1 (JIP1) Descriptor: SH3 domain of JNK-interacting Protein 1 (JIP1) Authors: Perez, L.M, Ielasi, F.S, Palencia, A, Jensen, M.R. Deposit date: 2021-03-22 Release date: 2021-12-22 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Visualizing protein breathing motions associated with aromatic ring flipping. Nature, 602, 2022
2N9B	Solution NMR Structure of Antiparallel Myosin-10:GCN4 Tandem Coiled-Coil Descriptor: Unconventional myosin-X, General control protein GCN4 fusion Authors: Vavra, K.C, Xia, Y, Rock, R.S. Deposit date: 2015-11-12 Release date: 2016-06-15 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Competition between Coiled-Coil Structures and the Impact on Myosin-10 Bundle Selection Biophys.J., 110, 2016
7OBS	Crystal structure of 14-3-3 sigma in complex with RIPK2 phosphopeptide Descriptor: 14-3-3 protein sigma, CALCIUM ION, MAGNESIUM ION, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-23 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBT	Crystal structure of 14-3-3 sigma in complex with RIPK2 phosphopeptide and stabilizer Fusicoccin-A Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-23 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7W6P	Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a G protein biased agonist Descriptor: Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Xu, J, Fink, E.A, Shoichet, B.K, Du, Y. Deposit date: 2021-12-02 Release date: 2022-09-28 Last modified: 2022-10-12 Method: ELECTRON MICROSCOPY (3.47 Å) Cite: Structure-based discovery of nonopioid analgesics acting through the alpha 2A -adrenergic receptor. Science, 377, 2022
7W7E	Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a biased agonist Descriptor: 5-(3-bicyclo[4.2.0]octa-1,3,5-trienyl)-1,2,3,6-tetrahydropyridine, Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Xu, J, Fink, E.A, Shoichet, B.K, Du, Y. Deposit date: 2021-12-04 Release date: 2022-09-28 Last modified: 2022-10-12 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structure-based discovery of nonopioid analgesics acting through the alpha 2A -adrenergic receptor. Science, 377, 2022
7W5A	The cryo-EM structure of human pre-C*-II complex Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... Authors: Zhan, X, Lu, Y, Shi, Y. Deposit date: 2021-11-29 Release date: 2022-06-22 Last modified: 2022-08-17 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
6ZSC	Human mitochondrial ribosome in complex with E-site tRNA Descriptor: 12S mitochondrial rRNA, 16S mitochondrial rRNA, 28S ribosomal protein S10, ... Authors: Aibara, S, Singh, V, Modelska, A, Amunts, A. Deposit date: 2020-07-15 Release date: 2020-09-16 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structural basis of mitochondrial translation. Elife, 9, 2020
1W76	Orthorhombic form of Torpedo californica acetylcholinesterase (AChE) complexed with bis-acting galanthamine derivative Descriptor: (-)-GALANTHAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE Authors: Greenblatt, H.M, Guillou, C, Guenard, D, Badet, B, Thal, C, Silman, I, Sussman, J.L. Deposit date: 2004-08-30 Release date: 2004-11-25 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.3 Å) Cite: The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design. J.Am.Chem.Soc., 126, 2004
5W5O	Identification of potent and selective RIPK2 inhibitors for the treatment of inflammatory diseases. Descriptor: 4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine, Receptor-interacting serine/threonine-protein kinase 2 Authors: Kreusch, A, Spraggon, G. Deposit date: 2017-06-15 Release date: 2017-10-25 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.89 Å) Cite: Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases. ACS Med Chem Lett, 8, 2017
5W5J	Identification of potent and selective RIPK2 inhibitors for the treatment of inflammatory diseases Descriptor: N-(2-chlorophenyl)pyrazolo[1,5-a]pyridine-3-carboxamide, Receptor-interacting serine/threonine-protein kinase 2, SULFATE ION Authors: Kreusch, A, Spraggon, G. Deposit date: 2017-06-15 Release date: 2017-10-25 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases. ACS Med Chem Lett, 8, 2017
7W59	The cryo-EM structure of human pre-C*-I complex Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... Authors: Zhan, X, Lu, Y, Shi, Y. Deposit date: 2021-11-29 Release date: 2022-06-22 Last modified: 2022-08-17 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
1W4L	Complex of TcAChE with bis-acting galanthamine derivative Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, ... Authors: Greenblatt, H.M, Guillou, C, Guenard, D, Badet, B, Thal, C, Silman, I, Sussman, J.L. Deposit date: 2004-07-25 Release date: 2004-11-25 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.16 Å) Cite: The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design. J.Am.Chem.Soc., 126, 2004
5K8D	Crystal structure of rFVIIIFc Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COPPER (II) ION, ... Authors: Leksa, N, Quan, C. Deposit date: 2016-05-29 Release date: 2017-06-14 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (4.19 Å) Cite: The structural basis for the functional comparability of factor VIII and the long-acting variant recombinant factor VIII Fc fusion protein. J. Thromb. Haemost., 15, 2017
5WA1	CHMP4C A232T in complex with ALIX BRO1 Descriptor: Charged multivesicular body protein 4c, Programmed cell death 6-interacting protein Authors: Wenzel, D.M, Alam, S.L, Sundquist, W.I. Deposit date: 2017-06-24 Release date: 2018-09-19 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.868 Å) Cite: A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
7RRC	IDO1 IN COMPLEX WITH COMPOUND 14 Descriptor: Indoleamine 2,3-dioxygenase 1, N-(4-fluorophenyl)-3-{4-[4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-3-yl]phenyl}oxetane-3-carboxamide Authors: Lesburg, C.A. Deposit date: 2021-08-09 Release date: 2022-03-16 Last modified: 2022-05-11 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing. J.Med.Chem., 65, 2022
7RRB	IDO1 IN COMPLEX WITH COMPOUND 9 Descriptor: 3-[4-(6-cyclopropylpyridin-3-yl)phenyl]-N-(4-fluorophenyl)oxetane-3-carboxamide, Indoleamine 2,3-dioxygenase 1 Authors: Lesburg, C.A. Deposit date: 2021-08-09 Release date: 2022-03-16 Last modified: 2022-05-11 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing. J.Med.Chem., 65, 2022
8RHN	Structure of the 55LCC ATPase complex Descriptor: ATPase family gene 2 protein homolog A, ATPase family gene 2 protein homolog B, Cyclin-dependent kinase 2-interacting protein, ... Authors: Foglizzo, M, Degtjarik, O, Zeqiraj, E. Deposit date: 2023-12-15 Release date: 2024-03-27 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity. Cell, 187, 2024
6YXJ	Crystal structure of SARS-CoV macrodomain II in complex with human Paip1 Descriptor: Non-structural protein 3, Polyadenylate-binding protein-interacting protein 1 Authors: Lei, J, Hilgenfeld, R. Deposit date: 2020-05-02 Release date: 2021-03-17 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (3.5 Å) Cite: The SARS-unique domain (SUD) of SARS-CoV and SARS-CoV-2 interacts with human Paip1 to enhance viral RNA translation. Embo J., 40, 2021
4LHZ	Crystal structure of GTP-bound Rab8:Rabin8 Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Rab-3A-interacting protein, Ras-related protein Rab-8A Authors: Guo, Z, Hou, X.M, Goody, R.S, Itzen, A. Deposit date: 2013-07-01 Release date: 2013-10-09 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB. J.Biol.Chem., 288, 2013
4LHY	Crystal structure of GDP-bound Rab8:Rabin8 Descriptor: GUANOSINE-5'-DIPHOSPHATE, Rab-3A-interacting protein, Ras-related protein Rab-8A, ... Authors: Guo, Z, Hou, X.M, Goody, R.S, Itzen, A. Deposit date: 2013-07-01 Release date: 2013-10-09 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB. J.Biol.Chem., 288, 2013
7W5B	The cryo-EM structure of human C* complex Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... Authors: Zhan, X, Lu, Y, Shi, Y. Deposit date: 2021-11-29 Release date: 2022-06-22 Last modified: 2022-08-17 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
5VXB	Crystal structure of Caulobacter crescentus ProXp-ala at 1.69 Angstrom Descriptor: ProXp-ala Authors: Foster, M.P, Musier-Forsyth, K, Nakanishi, K, Ma, X. Deposit date: 2017-05-23 Release date: 2017-08-09 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.69 Å) Cite: Conformational and chemical selection by a trans-acting editing domain. Proc. Natl. Acad. Sci. U.S.A., 114, 2017

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