5W5J
Identification of potent and selective RIPK2 inhibitors for the treatment of inflammatory diseases
Summary for 5W5J
Entry DOI | 10.2210/pdb5w5j/pdb |
Related | 5W5W |
Descriptor | Receptor-interacting serine/threonine-protein kinase 2, N-(2-chlorophenyl)pyrazolo[1,5-a]pyridine-3-carboxamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, kinase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : O43353 |
Total number of polymer chains | 2 |
Total formula weight | 72079.41 |
Authors | Kreusch, A.,Spraggon, G. (deposition date: 2017-06-15, release date: 2017-10-25, Last modification date: 2024-04-03) |
Primary citation | He, X.,Da Ros, S.,Nelson, J.,Zhu, X.,Jiang, T.,Okram, B.,Jiang, S.,Michellys, P.Y.,Iskandar, M.,Espinola, S.,Jia, Y.,Bursulaya, B.,Kreusch, A.,Gao, M.Y.,Spraggon, G.,Baaten, J.,Clemmer, L.,Meeusen, S.,Huang, D.,Hill, R.,Nguyen-Tran, V.,Fathman, J.,Liu, B.,Tuntland, T.,Gordon, P.,Hollenbeck, T.,Ng, K.,Shi, J.,Bordone, L.,Liu, H. Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases. ACS Med Chem Lett, 8:1048-1053, 2017 Cited by PubMed: 29057049DOI: 10.1021/acsmedchemlett.7b00258 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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