5W5J
Identification of potent and selective RIPK2 inhibitors for the treatment of inflammatory diseases
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Receptor-interacting serine/threonine-protein kinase 2 | polymer | 310 | 35623.9 | 2 | UniProt (O43353) Pfam (PF07714) | Homo sapiens (Human) | CARD-containing interleukin-1 beta-converting enzyme-associated kinase,CARD-containing IL-1 beta ICE-kinase,RIP-like-interacting CLARP kinase,Receptor-interacting protein 2,RIP-2,Tyrosine-protein kinase RIPK2 |
| 2 | C, F (A, B) | N-(2-chlorophenyl)pyrazolo[1,5-a]pyridine-3-carboxamide | non-polymer | 271.7 | 2 | Chemie (9WS) | |||
| 3 | D, E, G (A, B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 25 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71247.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 831.6 | |
| All* | Total formula weight | 72079.4 |
