PDB: 1263 resultsInfo pagesStatus searchChemie searchBIRD

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7FV7	PanDDA analysis group deposition -- PHIP in complex with Z1929967066 Descriptor: (3R)-4-(furan-2-carbonyl)-3-methyl-N-(propan-2-yl)piperazine-1-carboxamide, PH-interacting protein Authors: Grosjean, H, Tomlinson, C, Bradshaw, W.J, Koekemoer, L, Krojer, T, Fearon, D, Biggin, P.C, von Delft, F. Deposit date: 2023-03-09 Release date: 2023-03-29 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.25 Å) Cite: PanDDA analysis group deposition To Be Published
7FV8	PanDDA analysis group deposition -- PHIP in complex with Z964297186 Descriptor: 4-(3-chlorobenzoyl)-N-[3-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-3-oxopropyl]-1,4-diazepane-1-carboxamide, PH-interacting protein Authors: Grosjean, H, Tomlinson, C, Bradshaw, W.J, Koekemoer, L, Krojer, T, Fearon, D, Biggin, P.C, von Delft, F. Deposit date: 2023-03-09 Release date: 2023-03-29 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.15 Å) Cite: PanDDA analysis group deposition To Be Published
7FVD	PanDDA analysis group deposition -- PHIP in complex with Z1424453050 Descriptor: 4-(thieno[3,2-b]thiophene-2-carbonyl)-N-[(2S)-2,3,3-trimethylbutyl]piperazine-1-carboxamide, PH-interacting protein Authors: Grosjean, H, Tomlinson, C, Bradshaw, W.J, Koekemoer, L, Krojer, T, Fearon, D, Biggin, P.C, von Delft, F. Deposit date: 2023-03-09 Release date: 2023-03-29 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.36 Å) Cite: PanDDA analysis group deposition To Be Published
7FVE	PanDDA analysis group deposition -- PHIP in complex with Z488932160 Descriptor: 4-(5-bromofuran-2-carbonyl)-N-[3-(3-methylphenoxy)propyl]piperazine-1-carboxamide, PH-interacting protein Authors: Grosjean, H, Tomlinson, C, Bradshaw, W.J, Koekemoer, L, Krojer, T, Fearon, D, Biggin, P.C, von Delft, F. Deposit date: 2023-03-09 Release date: 2023-03-29 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.19 Å) Cite: PanDDA analysis group deposition To Be Published
3EF7	ZP-N domain of mammalian sperm receptor ZP3 (crystal form III) Descriptor: CALCIUM ION, Maltose-binding periplasmic protein, LINKER, ... Authors: Monne, M, Jovine, L. Deposit date: 2008-09-08 Release date: 2008-12-02 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats Nature, 456, 2008
3EHS	Crystal structure of the extracellular domain of human corticotropin releasing factor receptor type 1 (CRFR1) Descriptor: alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, fusion protein of CRFR1 extracellular domain and MBP Authors: Pioszak, A.A, Xu, H.E. Deposit date: 2008-09-14 Release date: 2008-09-30 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.76 Å) Cite: Molecular Recognition of Corticotropin-releasing Factor by Its G-protein-coupled Receptor CRFR1. J.Biol.Chem., 283, 2008
6NEW	Apo structure of the activated truncation of Vav1 Descriptor: Proto-oncogene vav, ZINC ION Authors: Knapp, M.S, Elling, R.A, Ornelas, E. Deposit date: 2018-12-18 Release date: 2019-12-25 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Allosteric Inhibitors of VAV1 Block Guanine Nucleotide Exchange Activity To Be Published
6NF1	Vav1 inhibited by an allosteric inhibitor: Vav1 inhibitors block GEF activity Descriptor: (2S)-3-[(3S)-1-(ethylsulfonyl)piperidin-3-yl]-2-{[3-(4-methylphenyl)imidazo[1,2-a]pyrazin-8-yl]amino}propan-1-ol, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Proto-oncogene vav, ... Authors: Knapp, M.S, Elling, R.A, Ornelas, E. Deposit date: 2018-12-18 Release date: 2019-12-25 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Allosteric Inhibitors of VAV1 Block Guanine Nucleotide Exchange Activity To Be Published
3FIW	Structure of SCO0253, a Tetr-family transcriptional regulator from Streptomyces coelicolor Descriptor: DI(HYDROXYETHYL)ETHER, Putative tetR-family transcriptional regulator Authors: Singer, A.U, Xu, X, Chang, C, Gu, J, Edwards, A.M, Joachimiak, A, Savchenko, A, Midwest Center for Structural Genomics (MCSG) Deposit date: 2008-12-12 Release date: 2009-01-13 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure of SCO0253, a Tetr-family transcriptional regulator from Streptomyces coelicolor To be Published
7JXY	Structure of TTBK1 kinase domain in complex with Compound 18 Descriptor: (3S)-1-[1-(2-aminopyrimidin-4-yl)-1H-pyrazolo[4,3-c]pyridin-6-yl]-3-methylpent-1-yn-3-ol, Tau-tubulin kinase 1 Authors: Chodaprambil, J.V. Deposit date: 2020-08-28 Release date: 2021-05-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo. J.Med.Chem., 64, 2021
7JXX	Structure of TTBK1 kinase domain in complex with Compound 3 Descriptor: 4-(2-amino-5,6,7,8-tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-b]indol-11-yl)-2-methylbut-3-yn-2-ol, SODIUM ION, Tau-tubulin kinase 1 Authors: Chodaprambil, J.V. Deposit date: 2020-08-28 Release date: 2021-05-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo. J.Med.Chem., 64, 2021
7JZB	Dihydrodipicolinate synthase S48W with lysine in the allosteric site, and pyruvate and succinic semi-aldehyde Descriptor: 4-hydroxy-tetrahydrodipicolinate synthase, LYSINE, POTASSIUM ION Authors: Board, A.J, Dobson, R.C.J. Deposit date: 2020-09-01 Release date: 2021-09-22 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.93 Å) Cite: Mapping the uncharted water channel of DHDPS To Be Published
7JZC	Dihydrodipicolinate synthase S48W mutant with lysine in the allosteric site, and pyruvate in the catalytic site Descriptor: 4-hydroxy-tetrahydrodipicolinate synthase, POTASSIUM ION Authors: Board, A.J, Dobson, R.C.J. Deposit date: 2020-09-02 Release date: 2021-09-22 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Mapping the uncharted water channel of DHDPS To Be Published
7JZD	Dihydrodipicolinate synthase mutation S48W with Lysine in the allosteric site Descriptor: 4-hydroxy-tetrahydrodipicolinate synthase, GLYCEROL, POTASSIUM ION Authors: Board, A.J, Dobson, R.C.J. Deposit date: 2020-09-02 Release date: 2021-09-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Mapping the uncharted water channel of DHDPS To Be Published
7JZG	Dihydrodipicolinate synthase mutant S48F with lysine in the allosteric site and pyruvate in the catalytic site Descriptor: 4-hydroxy-tetrahydrodipicolinate synthase, GLYCEROL, LYSINE, ... Authors: Board, A.J, Dobson, R.C.J. Deposit date: 2020-09-02 Release date: 2021-09-22 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Mapping the uncharted water channel of DHDPS To Be Published
7JZF	Dihydrodipicolinate synthase mutant S48F with pyruvate in the catalytic site Descriptor: 4-hydroxy-tetrahydrodipicolinate synthase, GLYCEROL, POTASSIUM ION Authors: Board, A.J, Dobson, R.C.J. Deposit date: 2020-09-02 Release date: 2021-09-22 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Mapping the uncharted water channel of DHDPS To Be Published
7JZ9	Dihydrodipicolinate synthase S48F with pyruvate and succinic semi-aldehyde Descriptor: 4-hydroxy-tetrahydrodipicolinate synthase, GLYCEROL, POTASSIUM ION Authors: Board, A.J, Dobson, R.C.J. Deposit date: 2020-09-01 Release date: 2021-09-22 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Mapping the uncharted water channel of DHDPS To Be Published
7JZE	Dihydrodipicolinate synthase mutant S48W Descriptor: 4-hydroxy-tetrahydrodipicolinate synthase, GLYCEROL, POTASSIUM ION Authors: Board, A.J, Dobson, R.C.J. Deposit date: 2020-09-02 Release date: 2021-09-22 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2 Å) Cite: Mapping the uncharted water channel of DHDPS To Be Published
7JZA	Dihydrodipicolinate synthase S48F mutant with lysine in the allosteric site, and pyruvate and succinic semi-aldehyde in the catalytic site Descriptor: 4-hydroxy-tetrahydrodipicolinate synthase, GLYCEROL, LYSINE, ... Authors: Board, A.J, Dobson, R.C.J. Deposit date: 2020-09-01 Release date: 2021-09-22 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Mapping the uncharted water channel of DHDPS To Be Published
7JZ7	Dihydrodipicolinate synthase mutant S48F Descriptor: 4-hydroxy-tetrahydrodipicolinate synthase, GLYCEROL, POTASSIUM ION Authors: Board, A.J, Dobson, R.C.J. Deposit date: 2020-09-01 Release date: 2021-10-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Mapping the unchartered waters of dihydrodipicolinate synthase: a novel mechanism of allosteric inhibition. To Be Published
7JZ8	Dihydrodipicolinate synthase mutant S48F with lysine in the allosteric site Descriptor: 4-hydroxy-tetrahydrodipicolinate synthase, LYSINE, POTASSIUM ION Authors: Board, A.J, Dobson, R.C.J. Deposit date: 2020-09-01 Release date: 2021-10-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Mapping the unchartered waters of dihydrodipicolinate synthase: a novel mechanism of allosteric inhibition. To Be Published
7K66	Structure of Blood Coagulation Factor VIII in Complex with an Anti-C1 Domain Pathogenic Antibody Inhibitor Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2A9 heavy chain, ... Authors: Childers, K.C, Gish, J, Jarvis, L, Peters, S, Garrels, C, Smith, I.W, Spencer, H.T, Spiegel, P.C. Deposit date: 2020-09-18 Release date: 2020-10-14 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.92 Å) Cite: Structure of blood coagulation factor VIII in complex with an anti-C1 domain pathogenic antibody inhibitor. Blood, 137, 2021
7KBT	Factor VIII in complex with the anti-C2 domain antibody, G99 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Ronayne, E.K, Gish, J, Wilson, C, Peters, S, Spencer, H.T, Spiegel, P.C, Childers, K.C. Deposit date: 2020-10-02 Release date: 2020-11-18 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (4.15 Å) Cite: Structure of Blood Coagulation Factor VIII in Complex With an Anti-C2 Domain Non-Classical, Pathogenic Antibody Inhibitor Front Immunol, 12, 2021
7KWO	rFVIIIFc-VWF-XTEN (BIVV001) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COPPER (II) ION, ... Authors: Fuller, J.R, Batchelor, J.D. Deposit date: 2020-12-01 Release date: 2021-03-03 Last modified: 2021-06-09 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Molecular determinants of the factor VIII/von Willebrand factor complex revealed by BIVV001 cryo-electron microscopy. Blood, 137, 2021
7KTR	Cryo-EM structure of the human SAGA coactivator complex (TRRAP, core) Descriptor: Ataxin-7, INOSITOL HEXAKISPHOSPHATE, Isoform 3 of Transcription factor SPT20 homolog, ... Authors: Herbst, D.A, Esbin, M.N, Nogales, E. Deposit date: 2020-11-24 Release date: 2021-11-10 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (2.93 Å) Cite: Structure of the human SAGA coactivator complex. Nat.Struct.Mol.Biol., 28, 2021

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