PDB Search results for query - Protein Data Bank Japan

PDB: 2 results

Structure of TTBK1 kinase domain in complex with Compound 18
Descriptor:	(3S)-1-[1-(2-aminopyrimidin-4-yl)-1H-pyrazolo[4,3-c]pyridin-6-yl]-3-methylpent-1-yn-3-ol, Tau-tubulin kinase 1
Authors:	Chodaprambil, J.V.
Deposit date:	2020-08-28
Release date:	2021-05-19
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.15 Å)
Cite:	Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo. J.Med.Chem., 64, 2021

Structure of TTBK1 kinase domain in complex with Compound 3
Descriptor:	4-(2-amino-5,6,7,8-tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-b]indol-11-yl)-2-methylbut-3-yn-2-ol, SODIUM ION, Tau-tubulin kinase 1
Authors:	Chodaprambil, J.V.
Deposit date:	2020-08-28
Release date:	2021-05-19
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.56 Å)
Cite:	Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo. J.Med.Chem., 64, 2021