7KWO
rFVIIIFc-VWF-XTEN (BIVV001)
Summary for 7KWO
| Entry DOI | 10.2210/pdb7kwo/pdb |
| EMDB information | 23057 |
| Descriptor | Coagulation factor FVIII-Fc-XTEN, von Willebrand factor-XTEN-Fc, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
| Functional Keywords | complex, hemophilia, fviii, vwf, blood clotting |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 399383.20 |
| Authors | Fuller, J.R.,Batchelor, J.D. (deposition date: 2020-12-01, release date: 2021-03-03, Last modification date: 2021-06-09) |
| Primary citation | Fuller, J.R.,Knockenhauer, K.E.,Leksa, N.C.,Peters, R.T.,Batchelor, J.D. Molecular determinants of the factor VIII/von Willebrand factor complex revealed by BIVV001 cryo-electron microscopy. Blood, 137:2970-2980, 2021 Cited by PubMed: 33569592DOI: 10.1182/blood.2020009197 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (2.9 Å) |
Structure validation
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