PDB: 5434 resultsInfo pagesStatus searchChemie searchBIRD

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4RXQ	The structure of GTP-dUTP-bound SAMHD1 Descriptor: DEOXYURIDINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Zhu, C.F, Wei, W, Peng, X, Dong, Y.H, Gong, Y, Yu, X.F. Deposit date: 2014-12-11 Release date: 2015-03-11 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP. Acta Crystallogr.,Sect.D, 71, 2015
4RV6	Human ARTD1 (PARP1) catalytic domain in complex with inhibitor Rucaparib Descriptor: Poly [ADP-ribose] polymerase 1, Rucaparib, SULFATE ION Authors: Karlberg, T, Thorsell, A.G, Schuler, H. Deposit date: 2014-11-25 Release date: 2015-12-09 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.19 Å) Cite: Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors. J. Med. Chem., 60, 2017
6Q82	Crystal structure of the biportin Pdr6 in complex with RanGTP Descriptor: GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, Importin beta-like protein KAP122, ... Authors: Aksu, M, Vera-Rodriguez, A, Trakhanov, S, Gorlich, D. Deposit date: 2018-12-14 Release date: 2019-05-01 Last modified: 2019-06-12 Method: X-RAY DIFFRACTION (2.994 Å) Cite: Structural basis for the nuclear import and export functions of the biportin Pdr6/Kap122. J.Cell Biol., 218, 2019
4TO3	Structural basis of cellular dNTP regulation, SAMHD1-dGTP-dGTP-dCTP complex Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... Authors: Ji, X, Tang, C, Zhao, Q, Wang, W, Xiong, Y. Deposit date: 2014-06-05 Release date: 2014-10-01 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural basis of cellular dNTP regulation by SAMHD1. Proc.Natl.Acad.Sci.USA, 111, 2014
4TO0	Structure basis of cellular dNTP regulation, SAMHD1-GTP-dATP-dCTP complex Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... Authors: Ji, X, Tang, C, Zhao, Q, Wang, W, Xiong, Y. Deposit date: 2014-06-05 Release date: 2014-10-01 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis of cellular dNTP regulation by SAMHD1. Proc.Natl.Acad.Sci.USA, 111, 2014
4S15	Crystal structure of the orphan nuclear receptor RORalpha ligand-binding domain in complex with 4alpha-caboxyl, 4beta-methyl-zymosterol (4ACD8) Descriptor: (3beta,4alpha,5beta,14beta)-3-hydroxy-4-methylcholesta-8,24-diene-4-carboxylic acid, GLYCEROL, Nuclear receptor ROR-alpha, ... Authors: Huang, P, Santori, F.R, Littman, D.R, Rastinejad, F. Deposit date: 2015-01-08 Release date: 2015-02-11 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.897 Å) Cite: Identification of Natural ROR gamma Ligands that Regulate the Development of Lymphoid Cells. Cell Metab, 21, 2015
4TNZ	Structure basis of cellular dNTP regulation, SAMHD1-GTP-dATP-dTTP complex Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Ji, X, Tang, C, Zhao, Q, Wang, W, Xiong, Y. Deposit date: 2014-06-05 Release date: 2014-10-01 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.38 Å) Cite: Structural basis of cellular dNTP regulation by SAMHD1. Proc.Natl.Acad.Sci.USA, 111, 2014
4TNR	Structure basis of cellular dNTP regulation, SAMHD1-GTP-dATP-dATP complex Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Ji, X, Tang, C, Zhao, Q, Wang, W, Xiong, Y. Deposit date: 2014-06-04 Release date: 2014-10-01 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Structural basis of cellular dNTP regulation by SAMHD1. Proc.Natl.Acad.Sci.USA, 111, 2014
4TO4	Structure basis of cellular dNTP regulation, SAMHD1-GTP-dGTP-dCTP complex Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... Authors: Ji, X, Tang, C, Zhao, Q, Wang, W, Xiong, Y. Deposit date: 2014-06-05 Release date: 2014-10-01 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural basis of cellular dNTP regulation by SAMHD1. Proc.Natl.Acad.Sci.USA, 111, 2014
4TNQ	Structural basis of cellular dNTP regulation, SAMHD1-GTP-dTTP-dTTP complex Descriptor: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Ji, X, Tang, C, Zhao, Q, Wang, W, Xiong, Y. Deposit date: 2014-06-04 Release date: 2014-10-01 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Structural basis of cellular dNTP regulation by SAMHD1. Proc.Natl.Acad.Sci.USA, 111, 2014
4TO6	Structure basis of cellular dNTP regulation, SAMHD1-dGTP-dATP-dTTP/dGTP complex Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... Authors: Ji, X, Tang, C, Zhao, Q, Wang, W, Xiong, Y. Deposit date: 2014-06-05 Release date: 2014-10-01 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.33 Å) Cite: Structural basis of cellular dNTP regulation by SAMHD1. Proc.Natl.Acad.Sci.USA, 111, 2014
4RXP	The structure of GTP-dATP-bound SAMHD1 Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Zhu, C.F, Wei, W, Peng, X, Dong, Y.H, Gong, Y, Yu, X.F. Deposit date: 2014-12-11 Release date: 2015-03-11 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP. Acta Crystallogr.,Sect.D, 71, 2015
4S0N	Crystal Structure of HLTF HIRAN Domain bound to DNA Descriptor: 5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3', GLYCEROL, Helicase-like transcription factor, ... Authors: Chavez, D.A, Eichman, B.F. Deposit date: 2015-01-02 Release date: 2015-05-27 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.501 Å) Cite: HLTF's Ancient HIRAN Domain Binds 3' DNA Ends to Drive Replication Fork Reversal. Mol.Cell, 58, 2015
4TNY	Structural basis of cellular dNTP regulation, SAMHD1-dGTP-dATP-dGTP complex Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... Authors: Ji, X, Tang, C, Zhao, Q, Wang, W, Xiong, Y. Deposit date: 2014-06-05 Release date: 2014-10-01 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural basis of cellular dNTP regulation by SAMHD1. Proc.Natl.Acad.Sci.USA, 111, 2014
4RTA	Cystal structure of the Dpy30 for MLL/SET1 COMPASS H3K4 trimethylation Descriptor: FORMIC ACID, Protein dpy-30 homolog Authors: Zhang, H.M, Li, M, Chang, W.R. Deposit date: 2014-11-14 Release date: 2015-10-07 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.123 Å) Cite: Structural implications of Dpy30 oligomerization for MLL/SET1 COMPASS H3K4 trimethylation. Protein Cell, 6, 2015
6QYQ	Crystal structure of human thymidylate synthase (hTS) variant R175C Descriptor: CHLORIDE ION, N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, SULFATE ION, ... Authors: Pozzi, C, Mangani, M. Deposit date: 2019-03-09 Release date: 2019-04-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors. Molecules, 24, 2019
6QP5	Apo Human Calcium/Calmodulin-dependent kinase type 1D Descriptor: 1,2-ETHANEDIOL, Calcium/calmodulin-dependent protein kinase type 1D, SULFATE ION Authors: Sorrell, F.J, Knapp, S. Deposit date: 2019-02-13 Release date: 2020-03-04 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Apo Human Calcium/Calmodulin-dependent kinase type 1D To Be Published
6QXH	Crystal structure of His-tag human thymidylate synthase (HT-hTS) in complex with dUMP Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Pozzi, C, Mangani, M. Deposit date: 2019-03-07 Release date: 2019-04-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Structural Comparison ofEnterococcus faecalisand Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities. Molecules, 24, 2019
6QXG	Crystal structure of His-tag human thymidylate synthase (HT-hTS) in complex with FdUMP Descriptor: 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, SULFATE ION, Thymidylate synthase Authors: Pozzi, C, Mangani, M. Deposit date: 2019-03-07 Release date: 2019-04-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Structural Comparison ofEnterococcus faecalisand Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities. Molecules, 24, 2019
4TO1	Structure basis of cellular dNTP regulation, SAMHD1-GTP-dATP/dCTP-dCTP complex Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... Authors: Ji, X, Tang, C, Zhao, Q, Wang, W, Xiong, Y. Deposit date: 2014-06-05 Release date: 2014-10-01 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Structural basis of cellular dNTP regulation by SAMHD1. Proc.Natl.Acad.Sci.USA, 111, 2014
6QZP	High-resolution cryo-EM structure of the human 80S ribosome Descriptor: (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 18S rRNA (1740-MER), 28S rRNA (3773-MER), ... Authors: Natchiar, S.K, Myasnikov, A.G, Kratzat, H, Hazemann, I, Klaholz, B.P. Deposit date: 2019-03-12 Release date: 2019-04-24 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Visualization of chemical modifications in the human 80S ribosome structure. Nature, 551, 2017
4RLS	Lactate Dehydrogenase in complex with inhibitor compound 47 Descriptor: (1R)-5'-[(2-chlorophenyl)sulfanyl]-4'-hydroxy-2,3-dihydrospiro[indene-1,2'-pyran]-6'(3'H)-one, (2S)-2-HYDROXYPROPANOIC ACID, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... Authors: Eigenbrot, C, Ultsch, M.H. Deposit date: 2014-10-17 Release date: 2014-11-12 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase. Bioorg.Med.Chem.Lett., 24, 2014
6R2E	Crystal structure of the human thymidylate synthase (hTS) interface variant Q62R Descriptor: CHLORIDE ION, GLYCEROL, N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, ... Authors: Pozzi, C, Mangani, M. Deposit date: 2019-03-16 Release date: 2019-04-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R. Biomolecules, 9, 2019
4TO2	Structure basis of cellular dNTP regulation, SAMHD1-dGTP-dGTP-dGTP/dTTP complex Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, MAGNESIUM ION, ... Authors: Ji, X, Tang, C, Zhao, Q, Wang, W, Xiong, Y. Deposit date: 2014-06-05 Release date: 2014-10-01 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.27 Å) Cite: Structural basis of cellular dNTP regulation by SAMHD1. Proc.Natl.Acad.Sci.USA, 111, 2014
6R4C	Aurora-A in complex with shape-diverse fragment 57 Descriptor: ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, CHLORIDE ION, ... Authors: Bayliss, R, McIntyre, P.J. Deposit date: 2019-03-22 Release date: 2019-05-01 Last modified: 2019-07-10 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Construction of a Shape-Diverse Fragment Set: Design, Synthesis and Screen against Aurora-A Kinase. Chemistry, 25, 2019

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