4RLS
Lactate Dehydrogenase in complex with inhibitor compound 47
Summary for 4RLS
| Entry DOI | 10.2210/pdb4rls/pdb |
| Descriptor | L-lactate dehydrogenase A chain, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, SULFATE ION, ... (6 entities in total) |
| Functional Keywords | oxidoreductase |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P00338 |
| Total number of polymer chains | 4 |
| Total formula weight | 149806.78 |
| Authors | Eigenbrot, C.,Ultsch, M.H. (deposition date: 2014-10-17, release date: 2014-11-12, Last modification date: 2024-02-28) |
| Primary citation | Fauber, B.P.,Dragovich, P.S.,Chen, J.,Corson, L.B.,Ding, C.Z.,Eigenbrot, C.,Labadie, S.,Malek, S.,Peterson, D.,Purkey, H.E.,Robarge, K.,Sideris, S.,Ultsch, M.,Wei, B.,Yen, I.,Yue, Q.,Zhou, A. Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase. Bioorg.Med.Chem.Lett., 24:5683-5687, 2014 Cited by PubMed: 25467161DOI: 10.1016/j.bmcl.2014.10.067 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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