4RXP
The structure of GTP-dATP-bound SAMHD1
Summary for 4RXP
Entry DOI | 10.2210/pdb4rxp/pdb |
Descriptor | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | hd-domain, hydrolase, dntp and gtp binding, phosphorylation |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : Q9Y3Z3 |
Total number of polymer chains | 2 |
Total formula weight | 128032.07 |
Authors | |
Primary citation | Zhu, C.F.,Wei, W.,Peng, X.,Dong, Y.H.,Gong, Y.,Yu, X.F. The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP. Acta Crystallogr.,Sect.D, 71:516-524, 2015 Cited by PubMed: 25760601DOI: 10.1107/S1399004714027527 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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