4RXP
The structure of GTP-dATP-bound SAMHD1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | polymer | 539 | 62486.2 | 2 | UniProt (Q9Y3Z3) Pfam (PF01966) | Homo sapiens (human) | dNTPase, Dendritic cell-derived IFNG-induced protein, DCIP, Monocyte protein 5, MOP-5, SAM domain and HD domain-containing protein 1 |
| 2 | C, D, I, J (A, B) | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE | non-polymer | 491.2 | 4 | Chemie (DTP) PubChem (622) PubChem (15993) PubChem (44119995) PubChem (448808) PubChem (46936612) PubChem (57233913) PubChem (91632917) PubChem (92341128) PubChem (92449119) PubChem (92449120) PubChem (89346292) PubChem (129069956) PubChem (171699368) | |||
| 3 | E, G (A, B) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 4 | F, H (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 5 | K, L (A, B) | water | water | 18.0 | 492 | Chemie (HOH) |
Sequence modifications
A, B: 109 - 626 (UniProt: Q9Y3Z3)
| PDB | External Database | Details |
|---|---|---|
| Met 88 | - | expression tag |
| Gly 89 | - | expression tag |
| Ser 90 | - | expression tag |
| Ser 91 | - | expression tag |
| His 92 | - | expression tag |
| His 93 | - | expression tag |
| His 94 | - | expression tag |
| His 95 | - | expression tag |
| His 96 | - | expression tag |
| His 97 | - | expression tag |
| Ser 98 | - | expression tag |
| Ser 99 | - | expression tag |
| Gly 100 | - | expression tag |
| Glu 101 | - | expression tag |
| Asn 102 | - | expression tag |
| Leu 103 | - | expression tag |
| Tyr 104 | - | expression tag |
| Phe 105 | - | expression tag |
| Gln 106 | - | expression tag |
| Gly 107 | - | expression tag |
| Ser 108 | - | expression tag |
| Tyr 266 | Cys 266 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 124972.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 3059.7 | |
| All* | Total formula weight | 128032.1 |
