8OX6
| Cryo-EM structure of ATP8B1-CDC50A in E1P conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cell cycle control protein 50A, MAGNESIUM ION, ... | Authors: | Dieudonne, T, Kummerer, F, Juknaviciute Laursen, M, Stock, C, Kock Flygaard, R, Khalid, S, Lenoir, G, Lyons, J.A, Lindorff-Larsen, K, Nissen, P. | Deposit date: | 2023-05-01 | Release date: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (2.39 Å) | Cite: | Activation and substrate specificity of the human P4-ATPase ATP8B1. Nat Commun, 14, 2023
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8OX7
| Cryo-EM structure of ATP8B1-CDC50A in E2P autoinhibited "closed" conformation | Descriptor: | (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Cell cycle control protein 50A, ... | Authors: | Dieudonne, T, Kummerer, F, Juknaviciute Laursen, M, Stock, C, Kock Flygaard, R, Khalid, S, Lenoir, G, Lyons, J.A, Lindorff-Larsen, K, Nissen, P. | Deposit date: | 2023-05-01 | Release date: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (2.56 Å) | Cite: | Activation and substrate specificity of the human P4-ATPase ATP8B1. Nat Commun, 14, 2023
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8OXC
| Cryo-EM structure of ATP8B1-CDC50A in E2-Pi conformation with occluded PI | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOINOSITOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Cell cycle control protein 50A, ... | Authors: | Dieudonne, T, Kummerer, F, Juknaviciute Laursen, M, Stock, C, Kock Flygaard, R, Khalid, S, Lenoir, G, Lyons, J.A, Lindorff-Larsen, K, Nissen, P. | Deposit date: | 2023-05-01 | Release date: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (2.58 Å) | Cite: | Activation and substrate specificity of the human P4-ATPase ATP8B1. Nat Commun, 14, 2023
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8OX9
| Cryo-EM structure of ATP8B1-CDC50A in E2P active conformation with bound PC | Descriptor: | (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Dieudonne, T, Kummerer, F, Juknaviciute Laursen, M, Stock, C, Kock Flygaard, R, Khalid, S, Lenoir, G, Lyons, J.A, Lindorff-Larsen, K, Nissen, P. | Deposit date: | 2023-05-01 | Release date: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (2.72 Å) | Cite: | Activation and substrate specificity of the human P4-ATPase ATP8B1. Nat Commun, 14, 2023
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8OXA
| Cryo-EM structure of ATP8B1-CDC50A in E2-Pi conformation with occluded PS | Descriptor: | (2~{S})-2-azanyl-3-[[(2~{R})-3-hexadecanoyloxy-2-[(~{Z})-octadec-9-enoyl]oxy-propoxy]-oxidanyl-phosphoryl]oxy-propanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Cell cycle control protein 50A, ... | Authors: | Dieudonne, T, Kummerer, F, Juknaviciute Laursen, M, Stock, C, Kock Flygaard, R, Khalid, S, Lenoir, G, Lyons, J.A, Lindorff-Larsen, K, Nissen, P. | Deposit date: | 2023-05-01 | Release date: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | Activation and substrate specificity of the human P4-ATPase ATP8B1. Nat Commun, 14, 2023
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6K7L
| Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E2P state class2) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BERYLLIUM TRIFLUORIDE ION, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | Deposit date: | 2019-06-07 | Release date: | 2019-08-28 | Last modified: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase. Science, 365, 2019
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6K7N
| Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1P state) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Cell cycle control protein 50A, ... | Authors: | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | Deposit date: | 2019-06-07 | Release date: | 2019-08-28 | Last modified: | 2021-02-10 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase. Science, 365, 2019
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8OX5
| Cryo-EM structure of ATP8B1-CDC50A in E1P-ADP conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, Cell cycle control protein 50A, ... | Authors: | Dieudonne, T, Kummerer, F, Juknaviciute Laursen, M, Stock, C, Kock Flygaard, R, Khalid, S, Lenoir, G, Lyons, J.A, Lindorff-Larsen, K, Nissen, P. | Deposit date: | 2023-05-01 | Release date: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Activation and substrate specificity of the human P4-ATPase ATP8B1. Nat Commun, 14, 2023
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6K7M
| Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E2Pi-PL state) | Descriptor: | (2~{S})-2-azanyl-3-[[(2~{R})-3-hexadecanoyloxy-2-[(~{Z})-octadec-9-enoyl]oxy-propoxy]-oxidanyl-phosphoryl]oxy-propanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | Deposit date: | 2019-06-07 | Release date: | 2019-08-28 | Last modified: | 2021-02-10 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase. Science, 365, 2019
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8OX8
| Cryo-EM structure of ATP8B1-CDC50A in E2P autoinhibited "open" conformation | Descriptor: | (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Cell cycle control protein 50A, ... | Authors: | Dieudonne, T, Kummerer, F, Juknaviciute Laursen, M, Stock, C, Kock Flygaard, R, Khalid, S, Lenoir, G, Lyons, J.A, Lindorff-Larsen, K, Nissen, P. | Deposit date: | 2023-05-01 | Release date: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Activation and substrate specificity of the human P4-ATPase ATP8B1. Nat Commun, 14, 2023
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8OXB
| Cryo-EM structure of ATP8B1-CDC50A in E2-Pi conformation with occluded PC | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Cell cycle control protein 50A, ... | Authors: | Dieudonne, T, Kummerer, F, Juknaviciute Laursen, M, Stock, C, Kock Flygaard, R, Khalid, S, Lenoir, G, Lyons, J.A, Lindorff-Larsen, K, Nissen, P. | Deposit date: | 2023-05-01 | Release date: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (2.99 Å) | Cite: | Activation and substrate specificity of the human P4-ATPase ATP8B1. Nat Commun, 14, 2023
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7BSV
| Cryo-EM structure of a human ATP11C-CDC50A flippase in PtdSer-occluded E2-AlF state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ATP11C, CDC50A, ... | Authors: | Abe, K, Nishizawa, T, Nakanishi, H. | Deposit date: | 2020-03-31 | Release date: | 2020-09-30 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM. Cell Rep, 32, 2020
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6K7K
| Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1-ADP-Pi state) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | Deposit date: | 2019-06-07 | Release date: | 2019-08-28 | Last modified: | 2021-02-10 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase. Science, 365, 2019
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6K7J
| Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1-ATP state class1) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Cell cycle control protein 50A, ... | Authors: | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | Deposit date: | 2019-06-07 | Release date: | 2019-08-28 | Last modified: | 2021-02-10 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase. Science, 365, 2019
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7PY4
| Cryo-EM structure of ATP8B1-CDC50A in E2P autoinhibited state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BERYLLIUM TRIFLUORIDE ION, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Dieudonne, T, Abad-Herrera, S, Juknaviciute Laursen, M, Lejeune, M, Stock, C, Slimani, K, Jaxel, C, Lyons, J.A, Montigny, C, Gunther Pomorski, T, Nissen, P, Lenoir, G. | Deposit date: | 2021-10-08 | Release date: | 2022-04-27 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders. Elife, 11, 2022
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7BSQ
| Cryo-EM structure of a human ATP11C-CDC50A flippase in E1AlF-ADP state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, ATP11C, ... | Authors: | Abe, K, Nishizawa, T, Nakanishi, H. | Deposit date: | 2020-03-31 | Release date: | 2020-09-30 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM. Cell Rep, 32, 2020
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7BSU
| Cryo-EM structure of a human ATP11C-CDC50A flippase in PtdSer-bound E2BeF state | Descriptor: | 1-deoxy-alpha-D-mannopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ATP11C, ... | Authors: | Abe, K, Nishizawa, T, Nakanishi, H. | Deposit date: | 2020-03-31 | Release date: | 2020-09-30 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM. Cell Rep, 32, 2020
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6K7H
| Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1 state class2) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Cell cycle control protein 50A, ... | Authors: | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | Deposit date: | 2019-06-07 | Release date: | 2019-08-28 | Last modified: | 2021-02-10 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase. Science, 365, 2019
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6K7I
| Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1-ATP state class2) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Cell cycle control protein 50A, ... | Authors: | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | Deposit date: | 2019-06-07 | Release date: | 2019-08-28 | Last modified: | 2021-02-10 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase. Science, 365, 2019
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6K7G
| Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1 state class1) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Cell cycle control protein 50A, ... | Authors: | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | Deposit date: | 2019-06-07 | Release date: | 2019-08-28 | Last modified: | 2021-02-10 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase. Science, 365, 2019
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7BSS
| Cryo-EM structure of a human ATP11C-CDC50A flippase in E1AlF state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ATP11C, CDC50A, ... | Authors: | Abe, K, Nishizawa, T, Nakanishi, H. | Deposit date: | 2020-03-31 | Release date: | 2020-09-30 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM. Cell Rep, 32, 2020
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7VGI
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7VSH
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8OX4
| Cryo-EM structure of ATP8B1-CDC50A in E1-ATP conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cell cycle control protein 50A, MAGNESIUM ION, ... | Authors: | Dieudonne, T, Kummerer, F, Juknaviciute Laursen, M, Stock, C, Kock Flygaard, R, Khalid, S, Lenoir, G, Lyons, J.A, Lindorff-Larsen, K, Nissen, P. | Deposit date: | 2023-05-01 | Release date: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Activation and substrate specificity of the human P4-ATPase ATP8B1. Nat Commun, 14, 2023
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7VSG
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