7PY4

Cryo-EM structure of ATP8B1-CDC50A in E2P autoinhibited state

Summary for 7PY4

Entry DOI	10.2210/pdb7py4/pdb
EMDB information	13711
Descriptor	Phospholipid-transporting ATPase IC, Cell cycle control protein 50A, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	lipid transporter autoinhibition p-type atpase p4-atpase cdc50a, membrane protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	184580.07
Authors	Dieudonne, T.,Abad-Herrera, S.,Juknaviciute Laursen, M.,Lejeune, M.,Stock, C.,Slimani, K.,Jaxel, C.,Lyons, J.A.,Montigny, C.,Gunther Pomorski, T.,Nissen, P.,Lenoir, G. (deposition date: 2021-10-08, release date: 2022-04-27)
Primary citation	Dieudonne, T.,Herrera, S.A.,Laursen, M.J.,Lejeune, M.,Stock, C.,Slimani, K.,Jaxel, C.,Lyons, J.A.,Montigny, C.,Pomorski, T.G.,Nissen, P.,Lenoir, G. Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders. Elife, 11:-, 2022 Cited by PubMed: 35416773 DOI: 10.7554/eLife.75272 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.1 Å)

Structure validation