7PY4
Cryo-EM structure of ATP8B1-CDC50A in E2P autoinhibited state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phospholipid-transporting ATPase IC | polymer | 1256 | 144182.1 | 1 | UniProt (O43520) Pfam (PF16209) Pfam (PF00122) Pfam (PF13246) Pfam (PF16212) | Homo sapiens (Human) | ATPase class I type 8B member 1,Familial intrahepatic cholestasis type 1,P4-ATPase flippase complex alpha subunit ATP8B1 |
| 2 | B (B) | Cell cycle control protein 50A | polymer | 327 | 37331.8 | 1 | UniProt (Q9NV96) Pfam (PF03381) | Homo sapiens (Human) | P4-ATPase flippase complex beta subunit TMEM30A,Transmembrane protein 30A |
| 3 | C (C) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | E (A) | BERYLLIUM TRIFLUORIDE ION | non-polymer | 66.0 | 1 | Chemie (BEF) | |||
| 6 | F, G, H, I (A, B) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 4 | Chemie (Y01) | |||
| 7 | J, K (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
A: 1 - 1251 (UniProt: O43520)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Thr 1152 | Ala 1152 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 181513.9 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 586.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2479.6 | |
| All* | Total formula weight | 184580.1 |
