6XAR
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7SIY
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![BU of 7siy by Molmil](/molmil-images/mine/7siy) | cCBL TKB domain in complex with pZAP70 peptide | Descriptor: | E3 ubiquitin-protein ligase CBL, MAGNESIUM ION, Peptide from Tyrosine-protein kinase ZAP-70 | Authors: | Murray, J.M, Yu, C. | Deposit date: | 2021-10-15 | Release date: | 2022-11-09 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | cCBL TKB domain in complex with pZAP70 peptide To Be Published
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5AXI
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![BU of 5axi by Molmil](/molmil-images/mine/5axi) | Crystal structure of Cbl-b TKB domain in complex with Cblin | Descriptor: | CALCIUM ION, CHLORIDE ION, Cblin, ... | Authors: | Ohno, A, Maita, N, Ochi, A, Nakao, R, Nikawa, T. | Deposit date: | 2015-07-29 | Release date: | 2016-03-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural analysis of the TKB domain of ubiquitin ligase Cbl-b complexed with its small inhibitory peptide, Cblin Arch.Biochem.Biophys., 594, 2016
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4GPL
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![BU of 4gpl by Molmil](/molmil-images/mine/4gpl) | |
6BK5
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2CBL
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![BU of 2cbl by Molmil](/molmil-images/mine/2cbl) | N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE ON ZAP-70 | Descriptor: | CALCIUM ION, PROTO-ONCOGENE CBL, ZAP-70 | Authors: | Meng, W, Sawasdikosol, S, Burakoff, S.J, Eck, M.J. | Deposit date: | 1998-08-28 | Release date: | 1999-05-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase. Nature, 398, 1999
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1B47
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![BU of 1b47 by Molmil](/molmil-images/mine/1b47) | STRUCTURE OF THE N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE IN ZAP-70 | Descriptor: | CALCIUM ION, CBL | Authors: | Meng, W, Sawasdikosol, S, Burakoff, S.J, Eck, M.J. | Deposit date: | 1999-01-06 | Release date: | 1999-04-27 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase. Nature, 398, 1999
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1YVH
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5HL0
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![BU of 5hl0 by Molmil](/molmil-images/mine/5hl0) | Crystal Structure of c-Cbl TKBD in complex with SPRY2 peptide (54-60, pY55) Refined to 2.2A Resolution | Descriptor: | E3 ubiquitin-protein ligase CBL, SODIUM ION, Sprouty 2 (SPRY2) | Authors: | Lovell, S, Battaile, K.P, Mehzabeen, N, Zhang, N, Cooper, A, Gao, P, Perez, R.P. | Deposit date: | 2016-01-14 | Release date: | 2017-01-18 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structure of c-Cbl TKBD in complex with SPRY2 peptide (54-60, pY55) Refined to 2.2A Resolution To Be Published
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3VRP
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![BU of 3vrp by Molmil](/molmil-images/mine/3vrp) | Crystal structure of the tyrosine kinase binding domain of Cbl-c in complex with phospho-EGFR peptide | Descriptor: | CALCIUM ION, Epidermal growth factor receptor, Signal transduction protein CBL-C | Authors: | Takeshita, K, Tezuka, T, Isozaki, Y, Yamashita, E, Suzuki, M, Yamanashi, Y, Yamamoto, T, Nakagawa, A. | Deposit date: | 2012-04-13 | Release date: | 2013-03-06 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c. J.Biochem., 152, 2012
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8VW5
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![BU of 8vw5 by Molmil](/molmil-images/mine/8vw5) | Crystal structure of Cbl-b TKB bound to compound 2 | Descriptor: | CALCIUM ION, E3 ubiquitin-protein ligase CBL-B, MAGNESIUM ION, ... | Authors: | Yu, C, Murray, J, Hsu, P.L. | Deposit date: | 2024-01-31 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding. Acs Med.Chem.Lett., 15, 2024
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8VW4
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![BU of 8vw4 by Molmil](/molmil-images/mine/8vw4) | Crystal structure of Cbl-b TKB bound to compound 26 | Descriptor: | (7-methoxy-2-{2-[(1S,3S,4S)-3-(3-methoxy-2-methyl-5-nitrophenyl)-1-methyl-5-oxo-1,5-dihydroimidazo[1,5-a]pyridin-2(3H)-yl]-2-oxoethoxy}quinolin-8-yl)acetic acid, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase CBL-B, ... | Authors: | Yu, C, Murray, J, Hsu, P.L. | Deposit date: | 2024-01-31 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding. Acs Med.Chem.Lett., 15, 2024
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3VRN
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![BU of 3vrn by Molmil](/molmil-images/mine/3vrn) | Crystal structure of the tyrosine kinase binding domain of Cbl-c | Descriptor: | CALCIUM ION, Signal transduction protein CBL-C | Authors: | Takeshita, K, Tezuka, T, Isozaki, Y, Yamashita, E, Suzuki, M, Yamanashi, Y, Yamamoto, T, Nakagawa, A. | Deposit date: | 2012-04-13 | Release date: | 2013-03-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c J.Biochem., 152, 2012
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6O02
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6O03
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5HKW
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![BU of 5hkw by Molmil](/molmil-images/mine/5hkw) | Crystal Structure of Apo c-Cbl TKBD Refined to 2.25 A Resolution | Descriptor: | E3 ubiquitin-protein ligase CBL, SODIUM ION | Authors: | Lovell, S, Battaile, K.P, Mehzabeen, N, Zhang, N, Cooper, A, Gao, P, Perez, R.P. | Deposit date: | 2016-01-14 | Release date: | 2017-01-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Crystal Structure of Apo c-Cbl TKBD Refined to 2.25 A Resolution To be published
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5HKY
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![BU of 5hky by Molmil](/molmil-images/mine/5hky) | Crystal structure of c-Cbl TKBD domain in complex with SPRY2 peptide (36-60, pY55) Refined to 1.8A Resolution (P6 form) | Descriptor: | CHLORIDE ION, E3 ubiquitin-protein ligase CBL, PENTAETHYLENE GLYCOL, ... | Authors: | Lovell, S, Battaile, K.P, Mehzabeen, N, Zhang, N, Cooper, A, Gao, P, Perez, R.P. | Deposit date: | 2016-01-14 | Release date: | 2017-01-18 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of c-Cbl TKBD domain in complex with SPRY2 peptide (36-60, pY55) Refined to 1.8A Resolution (P6 form) To be published
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5HKZ
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![BU of 5hkz by Molmil](/molmil-images/mine/5hkz) | Crystal Structure of c-Cbl TKBD in complex with SPRY2 peptide (36-60, pY55) Refined to 1.8 A Resolution (P21 form) | Descriptor: | E3 ubiquitin-protein ligase CBL, Protein sprouty homolog 2, SODIUM ION | Authors: | Lovell, S, Battaile, K.P, Mehzabeen, N, Zhang, N, Cooper, A, Gao, P, Perez, R.P. | Deposit date: | 2016-01-14 | Release date: | 2017-01-18 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of c-Cbl TKBD in complex with SPRY2 peptide (36-60, pY55) Refined to 1.8 A Resolution (P21 form) To be published
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3BUX
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![BU of 3bux by Molmil](/molmil-images/mine/3bux) | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in c-Met | Descriptor: | 13-meric peptide from Hepatocyte growth factor receptor, E3 ubiquitin-protein ligase CBL | Authors: | Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. | Deposit date: | 2008-01-03 | Release date: | 2008-02-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
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3PLF
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![BU of 3plf by Molmil](/molmil-images/mine/3plf) | Reverse Binding Mode of MetRD peptide complexed with c-Cbl TKB domain | Descriptor: | CALCIUM ION, CHLORIDE ION, E3 ubiquitin-protein ligase CBL, ... | Authors: | Sun, Q, Sivaraman, J. | Deposit date: | 2010-11-15 | Release date: | 2010-12-01 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding Febs Lett., 585, 2011
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3BUM
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![BU of 3bum by Molmil](/molmil-images/mine/3bum) | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty2 | Descriptor: | E3 ubiquitin-protein ligase CBL, Protein sprouty homolog 2 | Authors: | Ng, C, Jackson, A.R, Buschdorf, P.J, Sun, Q, Guy, R.G, Sivaraman, J. | Deposit date: | 2008-01-03 | Release date: | 2008-02-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
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3BUW
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![BU of 3buw by Molmil](/molmil-images/mine/3buw) | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Syk | Descriptor: | 13-meric peptide from Tyrosine-protein kinase SYK, E3 ubiquitin-protein ligase CBL | Authors: | Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. | Deposit date: | 2008-01-03 | Release date: | 2008-02-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
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3OB1
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3BUO
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![BU of 3buo by Molmil](/molmil-images/mine/3buo) | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor' | Descriptor: | 13-meric peptide from Epidermal growth factor receptor, E3 ubiquitin-protein ligase CBL | Authors: | Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. | Deposit date: | 2008-01-03 | Release date: | 2008-02-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
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3BUN
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![BU of 3bun by Molmil](/molmil-images/mine/3bun) | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty4 | Descriptor: | 13-meric peptide from Protein sprouty homolog 4, E3 ubiquitin-protein ligase CBL | Authors: | Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. | Deposit date: | 2008-01-03 | Release date: | 2008-02-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
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