3VRP
Crystal structure of the tyrosine kinase binding domain of Cbl-c in complex with phospho-EGFR peptide
Summary for 3VRP
Entry DOI | 10.2210/pdb3vrp/pdb |
Related | 3VRN 3VRO 3VRQ 3VRR |
Descriptor | Signal transduction protein CBL-C, Epidermal growth factor receptor, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | ptb domain, tkb (tyrosine kinase binding) domain, four-helix bundle (4h), calcium-binding ef hand, divergent sh2 domain, regulator of egfr mediated signal transduction, ubiquitously expressed, protein binding-transferase complex, protein binding/transferase |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus (Potential): Q9ULV8 Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 2 |
Total formula weight | 38356.71 |
Authors | Takeshita, K.,Tezuka, T.,Isozaki, Y.,Yamashita, E.,Suzuki, M.,Yamanashi, Y.,Yamamoto, T.,Nakagawa, A. (deposition date: 2012-04-13, release date: 2013-03-06) |
Primary citation | Takeshita, K.,Tezuka, T.,Isozaki, Y.,Yamashita, E.,Suzuki, M.,Kim, M.,Yamanashi, Y.,Yamamoto, T.,Nakagawa, A. Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c. J.Biochem., 152:487-495, 2012 Cited by PubMed: 22888118DOI: 10.1093/jb/mvs085 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.52 Å) |
Structure validation
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