7O1Q
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![BU of 7o1q by Molmil](/molmil-images/mine/7o1q) | Amyloid beta oligomer displayed on the alpha hemolysin scaffold | Descriptor: | Alpha-hemolysin hybridized Abeta | Authors: | Wu, J, Blum, T.B, Farrell, D.P, DiMaio, F, Abrahams, J.P, Luo, J. | Deposit date: | 2021-03-30 | Release date: | 2021-04-14 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-electron Microscopy Imaging of Alzheimer's Amyloid-beta 42 Oligomer Displayed on a Functionally and Structurally Relevant Scaffold. Angew.Chem.Int.Ed.Engl., 60, 2021
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4XXD
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![BU of 4xxd by Molmil](/molmil-images/mine/4xxd) | Crystal Structure of mid-region amyloid beta capture by solanezumab | Descriptor: | Amyloid-beta fragment, Fab Heavy Chain, Fab Light Chain | Authors: | Hermans, S.J, Crespi, G.A.N, Parker, M.W, Miles, L.A. | Deposit date: | 2015-01-30 | Release date: | 2015-04-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Molecular basis for mid-region amyloid-beta capture by leading Alzheimer's disease immunotherapies. Sci Rep, 5, 2015
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2YT1
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![BU of 2yt1 by Molmil](/molmil-images/mine/2yt1) | Solution structure of the chimera of the C-terminal tail peptide of APP and the C-terminal PID domain of Fe65L | Descriptor: | Amyloid beta A4 protein and Amyloid beta A4 precursor protein-binding family B member 2 | Authors: | Li, H, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-04-05 | Release date: | 2008-04-08 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid precursor protein reveals a novel peptide binding mode J.Biol.Chem., 283, 2008
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1HZ3
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![BU of 1hz3 by Molmil](/molmil-images/mine/1hz3) | ALZHEIMER'S DISEASE AMYLOID-BETA PEPTIDE (RESIDUES 10-35) | Descriptor: | A-BETA AMYLOID | Authors: | Zhang, S, Iwata, K, Lachenmann, M.J, Peng, J.W, Li, S, Stimson, E.R, Lu, Y, Felix, A.M, Maggio, J.E, Lee, J.P. | Deposit date: | 2001-01-23 | Release date: | 2001-01-31 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The Alzheimer's peptide a beta adopts a collapsed coil structure in water. J.Struct.Biol., 130, 2000
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3UMK
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![BU of 3umk by Molmil](/molmil-images/mine/3umk) | X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with copper | Descriptor: | ACETATE ION, Amyloid beta A4 protein, CADMIUM ION, ... | Authors: | Dahms, S.O, Konnig, I, Roeser, D, Guhrs, K.H, Than, M.E. | Deposit date: | 2011-11-13 | Release date: | 2012-01-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain. J.Mol.Biol., 416, 2012
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2YSZ
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![BU of 2ysz by Molmil](/molmil-images/mine/2ysz) | Solution structure of the chimera of the C-terminal PID domain of Fe65L and the C-terminal tail peptide of APP | Descriptor: | Amyloid beta A4 precursor protein-binding family B member 2 and Amyloid beta A4 protein | Authors: | Li, H, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-04-05 | Release date: | 2008-04-08 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid precursor protein reveals a novel peptide binding mode J.Biol.Chem., 283, 2008
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3UMH
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![BU of 3umh by Molmil](/molmil-images/mine/3umh) | X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with cadmium | Descriptor: | ACETATE ION, Amyloid beta A4 protein, CADMIUM ION | Authors: | Dahms, S.O, Konnig, I, Roeser, D, Guhrs, K.H, Than, M.E. | Deposit date: | 2011-11-13 | Release date: | 2012-01-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain. J.Mol.Biol., 416, 2012
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1IYT
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![BU of 1iyt by Molmil](/molmil-images/mine/1iyt) | Solution structure of the Alzheimer's disease amyloid beta-peptide (1-42) | Descriptor: | Alzheimer's disease amyloid | Authors: | Crescenzi, O, Tomaselli, S, Guerrini, R, Salvadori, S, D'Ursi, A.M, Temussi, P.A, Picone, D. | Deposit date: | 2002-09-06 | Release date: | 2003-02-11 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Solution structure of the Alzheimer amyloid beta-peptide (1-42) in an apolar microenvironment. Similarity with a virus fusion domain. EUR.J.BIOCHEM., 269, 2002
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7B3J
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![BU of 7b3j by Molmil](/molmil-images/mine/7b3j) | Dynamic complex between all-D-enantiomeric peptide D3 with wild-type amyloid precursor protein 672-726 fragment (amyloid beta 1-55) | Descriptor: | D3 all D-enantimeric peptide, Isoform L-APP677 of Amyloid-beta precursor protein | Authors: | Bocharov, E.V, Volynsky, P.E, Okhrimenko, I.S, Urban, A.S. | Deposit date: | 2020-12-01 | Release date: | 2021-01-13 | Last modified: | 2021-12-08 | Method: | SOLUTION NMR | Cite: | All - d - Enantiomeric Peptide D3 Designed for Alzheimer's Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-beta Precursors. J.Med.Chem., 64, 2021
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7JXN
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![BU of 7jxn by Molmil](/molmil-images/mine/7jxn) | |
1TAW
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![BU of 1taw by Molmil](/molmil-images/mine/1taw) | BOVINE TRYPSIN COMPLEXED TO APPI | Descriptor: | CALCIUM ION, PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR, TRYPSIN | Authors: | Hynes, T.R, Kossiakoff, A.A. | Deposit date: | 1996-12-19 | Release date: | 1997-06-24 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities. Protein Sci., 6, 1997
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6IYC
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![BU of 6iyc by Molmil](/molmil-images/mine/6iyc) | Recognition of the Amyloid Precursor Protein by Human gamma-secretase | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhou, R, Yang, G, Guo, X, Zhou, Q, Lei, J, Shi, Y. | Deposit date: | 2018-12-14 | Release date: | 2019-01-23 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Recognition of the amyloid precursor protein by human gamma-secretase. Science, 363, 2019
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7JXO
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![BU of 7jxo by Molmil](/molmil-images/mine/7jxo) | |
7B3K
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![BU of 7b3k by Molmil](/molmil-images/mine/7b3k) | Dynamic complex between all-D-enantiomeric peptide D3 with L723P mutant of amyloid precursor protein (APP) 672-726 fragment (amyloid beta 1-55) | Descriptor: | D3 all D-enantimeric peptide, Isoform L-APP677 of Amyloid-beta precursor protein | Authors: | Bocharov, E.V, Volynsky, P.E, Okhrimenko, I.S, Urban, A.S. | Deposit date: | 2020-12-01 | Release date: | 2021-01-13 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | All - d - Enantiomeric Peptide D3 Designed for Alzheimer's Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-beta Precursors. J.Med.Chem., 64, 2021
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1TKN
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![BU of 1tkn by Molmil](/molmil-images/mine/1tkn) | Solution structure of CAPPD*, an independently folded extracellular domain of human Amyloid-beta Precursor Protein | Descriptor: | Amyloid beta A4 protein | Authors: | Dulubova, I, Ho, A, Huryeva, I, Sudhof, T.C, Rizo, J. | Deposit date: | 2004-06-08 | Release date: | 2004-08-03 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Three-dimensional structure of an independently folded extracellular domain of human amyloid-beta precursor protein. Biochemistry, 43, 2004
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8OT1
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![BU of 8ot1 by Molmil](/molmil-images/mine/8ot1) | |
8OT3
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![BU of 8ot3 by Molmil](/molmil-images/mine/8ot3) | |
8OT4
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8OWJ
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![BU of 8owj by Molmil](/molmil-images/mine/8owj) | Lipidic amyloid-beta(1-40) fibril - polymorph L2-L2 | Descriptor: | Amyloid-beta A4 protein | Authors: | Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F. | Deposit date: | 2023-04-28 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40). Nat Commun, 15, 2024
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8OVM
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![BU of 8ovm by Molmil](/molmil-images/mine/8ovm) | Lipidic amyloid-beta(1-40) fibril - polymorph L2 | Descriptor: | Amyloid-beta A4 protein | Authors: | Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F. | Deposit date: | 2023-04-26 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40). Nat Commun, 15, 2024
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8OVK
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![BU of 8ovk by Molmil](/molmil-images/mine/8ovk) | Lipidic amyloid-beta(1-40) fibril - polymorph L1 | Descriptor: | Amyloid-beta A4 protein | Authors: | Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F. | Deposit date: | 2023-04-26 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.88 Å) | Cite: | Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40). Nat Commun, 15, 2024
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8OWE
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![BU of 8owe by Molmil](/molmil-images/mine/8owe) | Lipidic amyloid-beta(1-40) fibril - polymorph L2-L3 | Descriptor: | Amyloid-beta A4 protein | Authors: | Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F. | Deposit date: | 2023-04-27 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40). Nat Commun, 15, 2024
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8OWK
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![BU of 8owk by Molmil](/molmil-images/mine/8owk) | Lipidic amyloid-beta(1-40) fibril - polymorph L3-L3 | Descriptor: | Amyloid-beta A4 protein | Authors: | Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F. | Deposit date: | 2023-04-28 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.86 Å) | Cite: | Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40). Nat Commun, 15, 2024
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8OWD
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![BU of 8owd by Molmil](/molmil-images/mine/8owd) | Lipidic amyloid-beta(1-40) fibril - polymorph L3 | Descriptor: | Amyloid-beta A4 protein | Authors: | Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F. | Deposit date: | 2023-04-27 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40). Nat Commun, 15, 2024
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8QN7
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![BU of 8qn7 by Molmil](/molmil-images/mine/8qn7) | Amyloid-beta 40 type 1 filament from the leptomeninges of individual with Alzheimer's disease and cerebral amyloid angiopathy | Descriptor: | Amyloid-beta A4 protein | Authors: | Yang, Y, Murzin, A.S, Peak-Chew, S.Y, Franco, C, Newell, K.L, Ghetti, B, Goedert, M, Scheres, S.H.W. | Deposit date: | 2023-09-25 | Release date: | 2023-12-13 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Cryo-EM structures of A beta 40 filaments from the leptomeninges of individuals with Alzheimer's disease and cerebral amyloid angiopathy. Acta Neuropathol Commun, 11, 2023
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