7B3J

Dynamic complex between all-D-enantiomeric peptide D3 with wild-type amyloid precursor protein 672-726 fragment (amyloid beta 1-55)

Summary for 7B3J

• Entry DOI: 10.2210/pdb7b3j/pdb
• Related: 1ze7 2llm
• NMR Information: BMRB: 34577
• Descriptor: Isoform L-APP677 of Amyloid-beta precursor protein, D3 all D-enantimeric peptide (2 entities in total)
• Functional Keywords: d-peptide, amyloid-beta, complex, transmembrane, protein binding
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 7597.91

Authors

Bocharov, E.V.,Volynsky, P.E.,Okhrimenko, I.S.,Urban, A.S. (deposition date: 2020-12-01, release date: 2021-01-13, Last modification date: 2021-12-08)

• Primary citation: Bocharov, E.V.,Gremer, L.,Urban, A.S.,Okhrimenko, I.S.,Volynsky, P.E.,Nadezhdin, K.D.,Bocharova, O.V.,Kornilov, D.A.,Zagryadskaya, Y.A.,Kamynina, A.V.,Kuzmichev, P.K.,Kutzsche, J.,Bolakhrif, N.,Muller-Schiffmann, A.,Dencher, N.A.,Arseniev, A.S.,Efremov, R.G.,Gordeliy, V.I.,Willbold, D.; All - d - Enantiomeric Peptide D3 Designed for Alzheimer's Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-beta Precursors.; J.Med.Chem., 64:16464-16479, 2021; PubMed: 34739758; DOI: 10.1021/acs.jmedchem.1c00632

Experimental method

SOLUTION NMR