7O7Y
 
 | | Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (high resolution) | | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | | Authors: | Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N. | | Deposit date: | 2021-04-14 | | Release date: | 2021-06-02 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.2 Å) | | Cite: | Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome.
Science, 372, 2021
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7OYD
 | | Cryo-EM structure of a rabbit 80S ribosome with zebrafish Dap1b | | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | | Authors: | Leesch, F, Lorenzo-Orts, L, Grishkovskaya, I, Kandolf, S, Belacic, K, Meinhart, A, Haselbach, D, Pauli, A. | | Deposit date: | 2021-06-24 | | Release date: | 2022-07-20 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.3 Å) | | Cite: | A molecular network of conserved factors keeps ribosomes dormant in the egg.
Nature, 613, 2023
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7O7Z
 | | Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (classified for pseudoknot) | | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | | Authors: | Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N. | | Deposit date: | 2021-04-14 | | Release date: | 2021-06-02 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome.
Science, 372, 2021
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8SCB
 | | Terminating ribosome with SRI-41315 | | Descriptor: | (2S,4aS)-2-cyclobutyl-10-methyl-3-phenyl-2,10-dihydropyrimido[4,5-b]quinoline-4,5(3H,4aH)-dione, 18S_rRNA, 28S_rRNA, ... | | Authors: | Yip, M.C.J, Coelho, J.P.L, Oltion, K, Tauton, J, Shao, S. | | Deposit date: | 2023-04-05 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Structure and consequences of eRF1 glued to the ribosomal decoding center
To Be Published
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8RJB
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8RJD
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8B6C
 | | Cryo-EM structure of ribosome-Sec61 in complex with cyclotriazadisulfonamide derivative CK147 | | Descriptor: | 28S rRNA, 4-[[9-(cyclohexylmethyl)-3-methylidene-5-(4-methylphenyl)sulfonyl-1,5,9-triazacyclododec-1-yl]sulfonyl]-~{N},~{N}-dimethyl-aniline, 5.8S rRNA, ... | | Authors: | Pauwels, E, Shewakramani, N.R, De Wijngaert, B, Vermeire, K, Das, K. | | Deposit date: | 2022-09-26 | | Release date: | 2023-02-22 | | Last modified: | 2023-03-15 | | Method: | ELECTRON MICROSCOPY (2.79 Å) | | Cite: | Structural insights into TRAP association with ribosome-Sec61 complex and translocon inhibition by a CADA derivative.
Sci Adv, 9, 2023
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8BPO
 | | Structure of rabbit 80S ribosome translating beta-tubulin in complex with tetratricopeptide protein 5 (TTC5) and S-phase Cyclin A Associated Protein residing in the ER (SCAPER) | | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | Authors: | Hopfler, M, Absmeier, E, Passmore, L.A, Hegde, R.S. | | Deposit date: | 2022-11-17 | | Release date: | 2023-07-05 | | Last modified: | 2023-07-19 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation.
Mol.Cell, 83, 2023
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7UCK
 | | 80S translation initiation complex with ac4c(-1) mRNA and Harringtonine | | Descriptor: | 18S rRNA, 28s rRNA, 40S ribosomal protein S10, ... | | Authors: | Yang, R, Arango, D, Sturgill, D, Oberdoerffer, S. | | Deposit date: | 2022-03-16 | | Release date: | 2022-06-01 | | Last modified: | 2022-08-17 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine.
Mol.Cell, 82, 2022
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7ZJW
 | | Rabbit 80S ribosome as it decodes the Sec-UGA codon | | Descriptor: | 18S rRNA, 28S rRNA, 40S Ribosomal protein eS19, ... | | Authors: | Hilal, T, Simonovic, M, Spahn, C.M.T. | | Deposit date: | 2022-04-12 | | Release date: | 2022-10-19 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon.
Science, 376, 2022
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7OBR
 | | RNC-SRP early complex | | Descriptor: | 28S rRNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | Authors: | Jomaa, A, Ban, N. | | Deposit date: | 2021-04-23 | | Release date: | 2021-07-21 | | Last modified: | 2021-07-28 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Molecular mechanism of cargo recognition and handover by the mammalian signal recognition particle.
Cell Rep, 36, 2021
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6SGC
 | | Rabbit 80S ribosome stalled on a poly(A) tail | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | | Authors: | Chandrasekaran, V, Juszkiewicz, S, Choi, J, Puglisi, J.D, Brown, A, Shao, S, Ramakrishnan, V, Hegde, R.S. | | Deposit date: | 2019-08-03 | | Release date: | 2019-12-04 | | Last modified: | 2022-03-30 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Mechanism of ribosome stalling during translation of a poly(A) tail.
Nat.Struct.Mol.Biol., 26, 2019
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7QWQ
 | | Ternary complex of ribosome nascent chain with SRP and NAC | | Descriptor: | 28S rRNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | Authors: | Jomaa, A, Gamerdinger, M, Hsieh, H, Wallisch, A, Chandrasekaran, V, Ulusoy, Z, Scaiola, A, Hegde, R, Shan, S, Ban, N, Deuerling, E. | | Deposit date: | 2022-01-25 | | Release date: | 2022-03-16 | | Last modified: | 2022-03-30 | | Method: | ELECTRON MICROSCOPY (2.83 Å) | | Cite: | Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting.
Science, 375, 2022
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8B5L
 | | Cryo-EM structure of ribosome-Sec61-TRAP (TRanslocon Associated Protein) translocon complex | | Descriptor: | 28S rRNA, 5.8S rRNA, 5S rRNA, ... | | Authors: | Pauwels, E, Shewakramani, N.R, De Wijngaert, B, Vermeire, K, Das, K. | | Deposit date: | 2022-09-23 | | Release date: | 2023-03-01 | | Last modified: | 2023-03-15 | | Method: | ELECTRON MICROSCOPY (2.86 Å) | | Cite: | Structural insights into TRAP association with ribosome-Sec61 complex and translocon inhibition by a CADA derivative.
Sci Adv, 9, 2023
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7TOR
 | | Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20 | | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | | Authors: | Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. | | Deposit date: | 2022-01-24 | | Release date: | 2022-05-25 | | Last modified: | 2022-06-01 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.
Nat Commun, 13, 2022
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8P2K
 | | Ternary complex of translating ribosome, NAC and METAP1 | | Descriptor: | 18s rRNA, 28S rRNA, 40S ribosomal protein S11, ... | | Authors: | Jia, M, Jaskolowski, M, Scaiola, A, Jomaa, A, Ban, N. | | Deposit date: | 2023-05-16 | | Release date: | 2023-07-19 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | NAC controls cotranslational N-terminal methionine excision in eukaryotes.
Science, 380, 2023
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7QWR
 | | Structure of the ribosome-nascent chain containing an ER signal sequence in complex with NAC | | Descriptor: | 28S rRNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | Authors: | Jomaa, A, Gamerdinger, M, Hsieh, H, Wallisch, A, Chandrasekaran, V, Ulusoy, Z, Scaiola, A, Hegde, R, Shan, S, Ban, N, Deuerling, E. | | Deposit date: | 2022-01-25 | | Release date: | 2022-03-09 | | Last modified: | 2022-03-23 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting.
Science, 375, 2022
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7O80
 | | Rabbit 80S ribosome in complex with eRF1 and ABCE1 stalled at the STOP codon in the mutated SARS-CoV-2 slippery site | | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | | Authors: | Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N. | | Deposit date: | 2021-04-14 | | Release date: | 2021-06-02 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome.
Science, 372, 2021
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8RJC
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6R5Q
 | | Structure of XBP1u-paused ribosome nascent chain complex (post-state) | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | | Authors: | Shanmuganathan, V, Cheng, J, Berninghausen, O, Beckmann, R. | | Deposit date: | 2019-03-25 | | Release date: | 2019-07-10 | | Last modified: | 2019-10-30 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural and mutational analysis of the ribosome-arresting human XBP1u.
Elife, 8, 2019
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6P5K
 | | Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 3) | | Descriptor: | 18S rRNA, 28S rRNA, 5.8S rRNA, ... | | Authors: | Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. | | Deposit date: | 2019-05-30 | | Release date: | 2019-09-18 | | Last modified: | 2020-01-08 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs.
Embo J., 38, 2019
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7TOQ
 | | Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein poly-PR | | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | | Authors: | Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. | | Deposit date: | 2022-01-24 | | Release date: | 2022-05-25 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.
Nat Commun, 13, 2022
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7UCJ
 | | Mammalian 80S translation initiation complex with mRNA and Harringtonine | | Descriptor: | 18S rRNA, 28s rRNA, 40S ribosomal protein S10, ... | | Authors: | Yang, R, Arango, D, Sturgill, D, Oberdoerffer, S. | | Deposit date: | 2022-03-16 | | Release date: | 2022-06-01 | | Last modified: | 2022-08-17 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine.
Mol.Cell, 82, 2022
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8BHF
 | | Cryo-EM structure of stalled rabbit 80S ribosomes in complex with human CCR4-NOT and CNOT4 | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S11, ... | | Authors: | Absmeier, E, Chandrasekaran, V, O'Reilly, F.J, Stowell, J.A.W, Rappsilber, J, Passmore, L.A. | | Deposit date: | 2022-10-31 | | Release date: | 2023-09-06 | | Last modified: | 2023-11-01 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.
Nat.Struct.Mol.Biol., 30, 2023
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7ZJX
 | | Rabbit 80S ribosome programmed with SECIS and SBP2 | | Descriptor: | 18S rRNA, 28S rRNA, 40S Ribosomal protein eS19, ... | | Authors: | Hilal, T, Simonovic, M, Spahn, C.M.T. | | Deposit date: | 2022-04-12 | | Release date: | 2022-09-07 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon.
Science, 376, 2022
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