PDB: 1731 件ウェブページステータス検索Chemie searchBIRD

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1IZO	Cytochrome P450 BS beta Complexed with Fatty Acid 分子名称: Cytochrome P450 152A1, PALMITOLEIC ACID, PROTOPORPHYRIN IX CONTAINING FE 著者 Lee, D.S, Yamada, A, Sugimoto, H, Matsunaga, I, Ogura, H, Ichihara, K, Adachi, S, Park, S.Y, Shiro, Y, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2002-10-10 公開日 2003-03-18 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Substrate Recognition and Molecular Mechanism of Fatty Acid Hydroxylation by Cytochrome P450 from Bacillus subtilis. CRYSTALLOGRAPHIC, SPECTROSCOPIC, AND MUTATIONAL STUDIES. J.Biol.Chem., 278, 2003
2ZQX	Cytochrome P450BSbeta cocrystallized with heptanoic acid 分子名称: Cytochrome P450 152A1, PROTOPORPHYRIN IX CONTAINING FE 著者 Shoji, O, Fujishiro, T, Nagano, S, Hirose, T, Shiro, Y, Watanabe, Y. 登録日 2008-08-22 公開日 2009-08-25 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Understanding substrate misrecognition of hydrogen peroxide dependent cytochrome P450 from Bacillus subtilis. J.Biol.Inorg.Chem., 2010
8SPD	Cytochrome P450 (CYP) 3A4 crystallized with clotrimazole 分子名称: 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE 著者 Hsu, M.H, Johnson, E.F. 登録日 2023-05-02 公開日 2023-10-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Differential Effects of Clotrimazole on X-Ray Crystal Structures of Human Cytochromes P450 3A5 and 3A4. Drug Metab.Dispos., 51, 2023
8SG5	Cytochrome P450 (CYP) 3A5 crystallized with clotrimazole 分子名称: 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, Cytochrome P450 3A5, DODECYL NONA ETHYLENE GLYCOL ETHER, ... 著者 Hsu, M.H, Johnson, E.F. 登録日 2023-04-11 公開日 2023-10-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Differential Effects of Clotrimazole on X-Ray Crystal Structures of Human Cytochromes P450 3A5 and 3A4. Drug Metab.Dispos., 51, 2023
7RL2	Crystal Structure of the Human Cytochrome P450 2C9*8 (CYP2C9*8) Genetic Variant in Complex with the Drug Losartan 分子名称: Cytochrome P450 2C9, PHOSPHATE ION, POTASSIUM ION, ... 著者 Shah, M.B. 登録日 2021-07-23 公開日 2021-10-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Insights into the Genetic Variations of Human Cytochrome P450 2C9: Structural Analysis, Characterization and Comparison. Int J Mol Sci, 22, 2021
6F0C	Cytochrome P450 TxtC employs substrate conformational switching for sequential aliphatic and aromatic thaxtomin hydroxylation 分子名称: (3~{R},6~{S})-1,4-dimethyl-6-[(4-nitro-1~{H}-indol-3-yl)methyl]-3-oxidanyl-3-(phenylmethyl)piperazine-2,5-dione, Cytochrome P450 monooxygenase, OXYGEN MOLECULE, ... 著者 Fulop, V. 登録日 2017-11-17 公開日 2018-12-12 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Binding of Distinct Substrate Conformations Enables Hydroxylation of Remote Sites in Thaxtomin D by Cytochrome P450 TxtC. J.Am.Chem.Soc., 141, 2019
6F0B	Cytochrome P450 TxtC employs substrate conformational switching for sequential aliphatic and aromatic thaxtomin hydroxylation 分子名称: (3~{S},6~{S})-1,4-dimethyl-3-[(4-nitro-1~{H}-indol-3-yl)methyl]-6-(phenylmethyl)piperazine-2,5-dione, Cytochrome P450 monooxygenase, PROTOPORPHYRIN IX CONTAINING FE 著者 Fulop, V. 登録日 2017-11-17 公開日 2018-12-12 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Binding of Distinct Substrate Conformations Enables Hydroxylation of Remote Sites in Thaxtomin D by Cytochrome P450 TxtC. J.Am.Chem.Soc., 141, 2019
4R21	Zebra fish cytochrome P450 17A2 with Progesterone 分子名称: Cytochrome P450 family 17 polypeptide 2, PROGESTERONE, PROTOPORPHYRIN IX CONTAINING FE 著者 Pallan, P.S, Egli, M. 登録日 2014-08-08 公開日 2014-12-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural and Kinetic Basis of Steroid 17 alpha, 20-Lyase Activity in Teleost Fish Cytochrome P450 17A1 and Its Absence in Cytochrome P450 17A2. J.Biol.Chem., 290, 2015
6MJM	Substrate Free Cytochrome P450 3A5 (CYP3A5) 分子名称: Cytochrome P450 3A5, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE 著者 Hsu, M.H, Johnson, E.F. 登録日 2018-09-21 公開日 2019-04-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Active-site differences between substrate-free and ritonavir-bound cytochrome P450 (CYP) 3A5 reveal plasticity differences between CYP3A5 and CYP3A4. J.Biol.Chem., 294, 2019
1W0F	Crystal structure of human cytochrome P450 3A4 分子名称: CYTOCHROME P450 3A4, PROGESTERONE, PROTOPORPHYRIN IX CONTAINING FE 著者 Williams, P.A, Cosme, J, Vinkovic, D.M, Ward, A, Angove, H.C, Day, P.J, Vonrhein, C, Tickle, I.J, Jhoti, H. 登録日 2004-06-03 公開日 2004-07-22 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone Science, 305, 2004
1W0E	Crystal structure of human cytochrome P450 3A4 分子名称: CYTOCHROME P450 3A4, PROTOPORPHYRIN IX CONTAINING FE 著者 Williams, P.A, Cosme, J, Vinkovic, D.M, Ward, A, Angove, H.C, Day, P.J, Vonrhein, C, Tickle, I.J, Jhoti, H. 登録日 2004-06-03 公開日 2004-07-22 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone Science, 305, 2004
1W0G	Crystal structure of human cytochrome P450 3A4 分子名称: CYTOCHROME P450 3A4, METYRAPONE, PROTOPORPHYRIN IX CONTAINING FE 著者 Williams, P.A, Cosme, J, Vinkovic, D.M, Ward, A, Angove, H.C, Day, P.J, Vonrhein, C, Tickle, I.J, Jhoti, H. 登録日 2004-06-03 公開日 2004-07-22 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.73 Å) 主引用文献 Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone Science, 305, 2004
1OG5	Structure of human cytochrome P450 CYP2C9 分子名称: CYTOCHROME P450 2C9, HEME C, S-WARFARIN 著者 Williams, P.A, Cosme, J, Ward, A, Angove, H.C, Matak Vinkovic, D, Jhoti, H. 登録日 2003-04-24 公開日 2003-07-17 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Crystal Structure of Human Cytochrome P450 2C9 with Bound Warfarin Nature, 424, 2003
1OG2	Structure of human cytochrome P450 CYP2C9 分子名称: CYTOCHROME P450 2C9, HEME C 著者 Williams, P.A, Cosme, J, Ward, A, Angove, H.C, Matak Vinkovic, D, Jhoti, H. 登録日 2003-04-23 公開日 2003-07-17 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structure of Human Cytochrome P450 2C9 with Bound Warfarin Nature, 424, 2003
5E9Z	Cytochrome P450 BM3 mutant M11 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Bifunctional cytochrome P450/NADPH--P450 reductase, FE (II) ION, ... 著者 Capoferri, L, Leth, R, ter Haar, E, Mohanty, A.K, Grootenhuis, D.J, Vottero, E, Commandeur, J.N.M, Vermeulen, N.P.E, Jorgensen, F.S, Olsen, L, Geerke, D.P. 登録日 2015-10-15 公開日 2016-01-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Insights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations. Proteins, 84, 2016
2JJN	Structure of closed cytochrome P450 EryK 分子名称: CYTOCHROME P450 113A1, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION 著者 Savino, C, Sciara, G, Miele, A.E, Kendrew, S.G, Vallone, B. 登録日 2008-04-15 公開日 2009-07-14 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Investigating the Structural Plasticity of a Cytochrome P450: Three-Dimensional Structures of P450 Eryk and Binding to its Physiological Substrate. J.Biol.Chem., 284, 2009
3ES9	NADPH-Cytochrome P450 Reductase in an Open Conformation 分子名称: FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Hamdane, D, Xia, C, Im, S.-C, Zhang, H, Kim, J.-J, Waskell, L. 登録日 2008-10-05 公開日 2009-01-20 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450 J.Biol.Chem., 284, 2009
2JJO	Structure of cytochrome P450 EryK in complex with its natural substrate erD 分子名称: CYTOCHROME P450 113A1, Erythromycin D, PROTOPORPHYRIN IX CONTAINING FE 著者 Savino, C, Sciara, G, Miele, A.E, Kendrew, S.G, Vallone, B. 登録日 2008-04-15 公開日 2009-07-14 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Investigating the Structural Plasticity of a Cytochrome P450: Three-Dimensional Structures of P450 Eryk and Binding to its Physiological Substrate. J.Biol.Chem., 284, 2009
6T1U	Cytochrome P450 reductase from Candida tropicalis 分子名称: FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADPH--cytochrome P450 reductase 著者 Opperman, D.J, Sewell, B.T. 登録日 2019-10-06 公開日 2020-01-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Biochemical and structural insights into the cytochrome P450 reductase from Candida tropicalis. Sci Rep, 9, 2019
6T1T	Cytochrome P450 reductase in complex with NADPH from Candida tropicalis 分子名称: FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Opperman, D.J, Sewell, B.T. 登録日 2019-10-06 公開日 2020-01-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Biochemical and structural insights into the cytochrome P450 reductase from Candida tropicalis. Sci Rep, 9, 2019
3EBS	Human Cytochrome P450 2A6 I208S/I300F/G301A/S369G in complex with Phenacetin 分子名称: Cytochrome P450 2A6, N-(4-ethoxyphenyl)acetamide, PROTOPORPHYRIN IX CONTAINING FE 著者 DeVore, N.M, Scott, E.E. 登録日 2008-08-28 公開日 2008-09-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Key residues controlling phenacetin metabolism by human cytochrome P4502A enzymes. Drug Metab.Dispos., 36, 2008
4Y8W	Crystal Structure of Human Cytochrome P450 21A2 Progesterone Complex 分子名称: Cytochrome P450 21-hydroxylase, PROGESTERONE, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Pallan, P.S, Lei, L, Egli, M. 登録日 2015-02-16 公開日 2015-04-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.64 Å) 主引用文献 Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYMEPROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE. J.Biol.Chem., 290, 2015
2H7Q	Cytochrome P450cam complexed with imidazole 分子名称: Cytochrome P450-cam, IMIDAZOLE, PROTOPORPHYRIN IX CONTAINING FE 著者 Verras, A, Alian, A, Montellano, P.R. 登録日 2006-06-02 公開日 2006-10-31 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Cytochrome P450 active site plasticity: attenuation of imidazole binding in cytochrome P450cam by an L244A mutation. Protein Eng.Des.Sel., 19, 2006
3UA1	Crystal structure of the cytochrome P4503A4-bromoergocryptine complex 分子名称: Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, bromoergocryptine 著者 Sevrioukova, I.F, Poulos, T.L. 登録日 2011-10-20 公開日 2011-12-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural and Mechanistic Insights into the Interaction of Cytochrome P4503A4 with Bromoergocryptine, a Type I Ligand. J.Biol.Chem., 287, 2012
4KPB	Crystal structure of cytochrome P450 BM-3 R47E mutant 分子名称: Cytochrome P450 BM-3, PROTOPORPHYRIN IX CONTAINING FE 著者 Sadre-Bazzaz, K, Catalano, J, McDermott, A.E, Tong, L. 登録日 2013-05-13 公開日 2013-07-24 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural Evidence: A Single Charged Residue Affects Substrate Binding in Cytochrome P450 BM-3. Biochemistry, 52, 2013

 

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